The first unveiling of Testatropin v2!!!

MAxximal said:
The guy is wrong I3C NOT destroy the libido only low too much the estrogen (and maybe he`s double the dose) , but you NEED ESTROGEN for the proper sexual functions in the body.
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Oh absolutely, it is why Letro and other research AI's kill libido. Estrogen is VERY important, just very misunderstood.
 
SupermanStrng said:
i LOVE the profile!

except i will NEVER use it due to inclusion of i3c.

good luck to those who use it and get picked for logging op.
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+1


MAxximal said:
Indole-3-Carbinol (I3C)

I3C is a naturally occurring compound derived from cruciferous vegetables such as broccoli, Brussels sprouts, and cabbage that actively promotes the breakdown of estrogen to the beneficial metabolite, 2-OH. However, modern diets are often deficient in these vegetables. Fortunately, research shows that supplementation with isolated, concentrated I3C promotes 2-hydroxlation of estrogen.64 Therefore, I3C is protective to
estrogen-sensitive tissues and may be beneficial to those with health issues related to estrogen dominance.

The mechanism by which I3C promotes 2-OH formation involves the selective induction of Phase 1 metabolizing cytochrome P450 enzymes (P450-1A1 and P450-1A2), which facilitate the 2-hydroxylation of estrogen.64,65 Through this metabolic role, I3C promotes an increased ratio of 2-OH to 16α-OH and may improve estrogen metabolism in women with poor diets or impaired detoxification.3,64,66 I3C may also reduce the activity of the enzyme required for the 4-hydroxylation of estrogen, thereby decreasing carcinogenic 4-OH formation.
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Yes, but I3C is an anti-androgen too:
Recently we constructed yeast cells that either express the human estrogen receptor α or the human androgen receptor in combination with a consensus ERE or ARE repeat in the promoter region of a green fluorescent protein (yEGFP) read-out system. These bioassays were proven to be highly specific for their cognate agonistic compounds. In this study the value of these yeast bioassays was assessed for analysis of compounds with antagonistic properties. Several pure antagonists, selective estrogen receptor modulators (SERMs) and plant-derived compounds were tested. The pure antiestrogens ICI 182,780 and RU 58668 were also classified as pure ER antagonists in the yeast estrogen bioassay and the pure antiandrogen flutamide was also a pure AR antagonist in the yeast androgen bioassay. The plant-derived compounds flavone and guggulsterone displayed both antiestrogenic and antiandrogenic activities, while 3,3′-diindolylmethane (DIM) and equol combined an estrogenic mode of action with an antiandrogenic activity. Indol-3-carbinol (I3C) only showed an antiandrogenic activity. Coumestrol, genistein, naringenin and 8-prenylnaringenin were estrogenic and acted additively, while the plant sterols failed to show any effect. Although hormonally inactive, in vitro and in vivo metabolism of the aforementioned plant sterols may still lead to the formation of active metabolites in other test systems.
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Why add an anti-androgen in a test booster?
 
JBerto said:
Only the abstract of that study, but there's too much studies showing that I3C is an anti-androgen

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Can you show me some studies with the amount of I3C that was used in them? I am very curious and open to a discussion about it. (At work currently)
 
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