Sometimes, it depends on the compound, how long you run it, and how you respond to it. I can run 6 weeks of epi and get away with very little cycle support and a simple pct. But 10 weeks of test with SD/4 weeks, I would use pretty much every product Jbry mentioned, tudca and NAC, milk thistle, all my bp meds and supports for CV health. And still be shut down hard and have rebound issues. Sides and recovery seem more complicated.