Unanswered Test Not Working Anymore, What Could It Be?

DarkDescartes

DarkDescartes

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Hey guys, first time poster and new to the peaktestosterone forums.

I'm going to keep this brief.

I did 2 test only cycles in 3 months each within an 8 month period in 2015. No AI nor HCG and everything was fine. I came off the first cycle not feeling 100 percent and stupidly followed my friends advice (not friends anymore) about going back on and coming off correctly and or even better.

The cycle was going well up until week 9 when i experience hormonal dysfunctions for the first time: fatigue, ed & libido issues, depression, etc. I stopped, did some hcg which i dont know if it was quality at the time, did nolva and clomid after and havent been right since.

I touched nothing for a year and a half until September 2017 when i decided to seek medical help. I've tried all the natural methods, hcg restarts, and did hgh, all of which provided benefits within the first few days to a week and never to work the same way again.

I also started trt in april 2018, restarted 4 different times. I felt great the very first time for the first 3 weeks in, but not again afterwards. each time i restarted, id feel good the first few days and then it stops. I've been doing the trt-hcg-ai combo and it seems i quite possibly cant handle hcg with trt.

I've dropped hcg a couple of weeks ago and decided yesterday was the last AI use ill use. I'm scheduled for blood work in late october.

My most recent bloods are the following:06/06/2019 blood work:
TOTAL GLUTATHIONE 752 (544-1228 uM)
OMEGA 3 (EPA+DHA) 2.1 (2.2-3.2)
OMEGA 6/OMEGA 3 RATIO 12.3 (5.7-21.3)
EPA/ARACHIDONIC ACID RATIO <0.1 (0.2 OR LESS)
ARACHIDONIC ACID 11.3 (5.2-12.9 %)
EPA 0.3 (0.2-1.5 %)
DHA 1.8 (1.2-3.9 %)
OSMOLALITY,SERUM 290 (275-295 mOsm/kg H2O)
MAGNESIUM 2.0 (1.5-2.5 mg/dL)
FIBRINOGEN ACTIV,CLAUSS FIBRINOGEN 237 (175-425 mg/dL)
FSH <0.7 L (1.6-8.0 mIU/mL)
LH <0.2 L (1.5-9.3 mIU/mL)
THYROID PEROXIDASE AB <1 <9 IU/mL
THYROGLOBULIN ANTIBODIES <1 < OR = 1 IU/mL
CERULOPLASMIN 31 (18-36 mg/dL)
VITAMIN C 0.7 (0.2-2.1 mg/dL)
TNF-ALPHA,HIGHLY SENSITIVE 0.54 L (0.56-1.40 pg/mL)
ESTRADIOL, ULTRASEN,LC/MS 51 H
DIHYDROTESTOSTERON,LCMSMS 64 (16-79 ng/dL)
TESTOSTERONE,TOTAL, MS 1387 H (250-1100 ng/dL)
TESTOSTERONE,FREE 274.6 H (35.0-155.0 pg/mL)
17-HYDROXYPROGESTERONE 40 (32-307 ng/dL)
VITAMIN A (RETINOL) 46 (38-98 mcg/dL)
IMMUNOGLOBULIN A 150 (81-463 mg/dL)
SEX HORMONE BINDING GLOB 41 (10-50 nmol/L)
WBC 2.9 L (3.8-10.8 Thousand/uL)
RBC 5.95 H (4.20-5.80 Million/uL)
HEMOGLOBIN 16.3 (13.2-17.1 g/dL)
HEMATOCRIT 49.5 (38.5-50.0 %)
MCV 83.2 (80.0-100.0 fL)
MCH 27.4 (27.0-33.0 pg)
MCHC 32.9 (32.0-36.0 g/dL)
RDW 15.3 H (11.0-15.0 %)
PLATELET COUNT 231 (140-400 Thousand/uL)
MPV 9.9 (7.5-12.5 fL)
TOTAL NEUTROPHILS,% 46.8 (38-80 %)
TOTAL LYMPHOCYTES,% 42.3 (15-49 %)
MONOCYTES,% 6.8 (0-13 %)
EOSINOPHILS,% 3.4 (0-8 %)
BASOPHILS,% 0.7 (0-2 %)
NEUTROPHILS,ABSOLUTE 1357 L (1500-7800 cells/uL)
LYMPHOCYTES,ABSOLUTE 1227 (850-3900 cells/uL)
MONOCYTES,ABSOLUTE 197 L (200-950 cells/uL)
EOSINOPHILS,ABSOLUTE 99 (15-500 cells/uL)
BASOPHILS,ABSOLUTE 20 (0-200 cells/uL)
ACTH,PLASMA 33 (6-50 pg/mL)
HEMOGLOBIN A1C 5.3 (<5.7 % of total Hgb)
COPPER 124 (70-175 mcg/dL)
MAGNESIUM,RBC 4.5 (4.0-6.4 mg/dL)
SELENIUM 142 (63-160 mcg/L)
ZINC 63 (60-130 mcg/dL)
VITAMIN B6, PLASMA 38.0 H (2.1-21.7 ng/mL)
VEGF,ELISA QNI VASCULAR ENDOTHELIAL GF <31 L (31-86 pg/mL)
HUMAN TGF BETA 1 (TGF-B1) 15460 H (344-2382 pg/mL)
VITAMIN B1 (THIAMINE), B 76 L (78-185 nmol/L)
VITAMIN E (TOCOPHEROL) AMD ALPHA-TOCOPHEROL 12.9 (5.7-19.9 mg/L)
Comp Metab Panel
GLUCOSE,FASTING 91 (65-99 mg/dL)
SODIUM 139 (135-146 mmol/L)
POTASSIUM 4.3 (3.5-5.3 mmol/L)
CHLORIDE 105 (98-110 mmol/L)
CARBON DIOXIDE 30 (20-32 mmol/L)
UREA NITROGEN 17 (7-25 mg/dL)
CREATININE 1.33 (0.60-1.35 mg/dL)
CALCIUM 9.4 (8.6-10.3 mg/dL)
PROTEIN, TOTAL 6.9 (6.1-8.1 g/dL)
ALBUMIN 4.4 (3.6-5.1 g/dL)
GLOBULIN 2.5 (1.9-3.7 g/dL) (calc)
ALBUMIN/GLOBULIN RATIO 1.8 (1.0-2.5) (calc)
BILIRUBIN,TOTAL 0.6 (0.2-1.2 mg/dL)
ALKALINE PHOSPHATASE 109 (40-115 U/L)
AST 37 (10-40 U/L)
ALT 28 (9-46 U/L)
EGFR NON AFR AMERICAN 73 >=60 mL/min/1.73m2
EGFR AFRICAN AMERICAN 85 >=60 mL/min/1.73m2
LIPID PANEL
CHOLESTEROL,TOTAL 175 (<200 mg/dL)
HDL CHOLESTEROL 62 (>40 mg/dL)
CHOLESTEROL/HDL RATIO 2.8 (<5.0 calc)
LDL-CHOLESTEROL 101 H (<100 mg/dL) (calc)
TRIGLYCERIDES 41 (<150 mg/dL)
NON HDL CHOLESTEROL 113 (<130 mg/dL) (calc)
GGT 10 (3-70 U/L)
IRON,TOTAL 75 (50-195 mcg/dL)
IRON BINDING CAPACITY 298 (250-425 mcg/dL) (calc)
IRON % SATURATION 25 (15-60 %)
TSH 1.34 (0.40-4.50 mIU/L)
T4,FREE 1.1 (0.8-1.8 ng/dL)
T3,FREE 3.0 (2.3-4.2 pg/mL)
LIPASE 46 (7-60 U/L)
FERRITIN 59 (20-345 ng/mL)
PROGESTERONE 0.5 (<1.4 ng/mL)
VITAMIN B12 510 (200-1100 pg/mL)
FOLATE,SERUM 13.4 (> 5.4 ng/mL)
CORTISOL (AM) 11.8 (4.0-22.0 mcg/dL)
INSULIN 3.0 (2.0-19.6 uIU/mL)
DHEA SULFATE 392 (85-690 mcg/dL)
HS CRP 0.8 mg/L
HOMOCYSTEINE 7.6 (<11.4 umol/L)
VITAMIN D,25-OH,TOTAL,IA 52 (30-100 ng/mL)
INTERLEUKIN-6(IL-6),SERUM <1.40 (<5.00 pg/mL)
PREGNENOLONE,LC/MS/MS 62 (22-237 ng/dL)
T3 REVERSE, LC/MS/MS 14 (8-25 ng/dL)
VIP <50 (<75 pg/mL)

Besides the obvious in terms of my test being a bit too high and my T/E2 ratio still off, I'd like to know if theres anything here that anybody sees that i could build a possible diagnosis from and begin to cure.

TGF1-Beta & VEGF are weirdly off and nothing online nor any doctor can tell me what it means.

I'm supplementing with pregnenolone, did a course of ferritin supplementation.

My trt dose for the next 2 months will be 100mg twice a week, no hcg, no ai.

Anybody got any suggestions on where to go from here besides waiting for my next round of bloods?
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ChocolateClen

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Get bloods, get everything tested. I mean everything. Test, estrogen, thyroid, psa etc. can’t do anything till we have numbers to work with. You aren’t dead so there has to be a reason why it’s not working
 
DarkDescartes

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Get bloods, get everything tested. I mean everything. Test, estrogen, thyroid, psa etc. can’t do anything till we have numbers to work with. You aren’t dead so there has to be a reason why it’s not working
You got it. I have bloods from June but at this point they're probably a little outdated.

When i get new bloods I'll report back!
 

Glockguy706

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Ok so you have low T becouse you never used a PCT. The fact you feel better for 3 weeks on cyp is most likely in your head after 3 weeks is when you should start to feel it and after 6 weeks it should level out . I am not an expert but I am pretty sure I am right . I would use what ever AI the doctor gave you if it is legit trt. And re test levels after 8 weeks or so .if it is self prescribed I would test levels of estrogen and add an AI from there . At this point I doubt you fully recover ever and most likely will.be on trt for life . Maybe you can recover with a really good pct and hcg but you will fill like **** for 4 or 5 months during recovery and during pct you will not fill better . It will not be untill your levels are normal or semi normal for 4 to 6 weeks that you feel decent.
 

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My low T levels and lack of "feeling good" was due to a very low vitamin D level. Once that was resolved my T went through the roof. I suggest having vitamin D level checked as this hormone is critical.
 

Whisky

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Bro you need a full blood panel, as @ChocolateClen says get everything tested then you can make a plan. You’ve clearly fucked your natural hormones but you need to drill down into specific problems to address them. Randomly throwing more drugs at it isn’t the answer buddy
 
ChocolateClen

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Ok so you have low T becouse you never used a PCT. The fact you feel better for 3 weeks on cyp is most likely in your head after 3 weeks is when you should start to feel it and after 6 weeks it should level out . I am not an expert but I am pretty sure I am right . I would use what ever AI the doctor gave you if it is legit trt. And re test levels after 8 weeks or so .if it is self prescribed I would test levels of estrogen and add an AI from there . At this point I doubt you fully recover ever and most likely will.be on trt for life . Maybe you can recover with a really good pct and hcg but you will fill like **** for 4 or 5 months during recovery and during pct you will not fill better . It will not be untill your levels are normal or semi normal for 4 to 6 weeks that you feel decent.
This is for the most part false. Test cyp has a 7 day half life so within 3-4 days you’re experiencing the full sides of it. He may be able to recover just fine wit a good restart. I feel better on cyp within 1-2 days
 

Glockguy706

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I guess I am wrong I generally dont feel any different on test cyp for a few weeks unless it is a lot . Hopefully you are right and he can restart with a good PCT . No one wants to be on TrT when they are young .
 

Glockguy706

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But him feeling great for the first 3 weeks of trt then not feeling good while still on trt doesnt make a lot of sense to me guess I will sit back and see how it plays out . Good luck op.
 
DarkDescartes

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Guys, if you actually read the post, you'd have all the info you need.

I've pcted after both test cycles. I didn't pct after superdrol, well i should say i thought i did. The guy who sold me superdrol said to come back and get pct products but knowing what i know now, it was bunk and just after the sale, letting me **** up my body for the sake of a measly commission.

I've done multiple restarts and the no avail, trt for life is my only route.

I dont really care about injecting for life, i accepted my fate and the bright side is being at youthful levels for my entire existence.

The problem is finding out why test isnt working the same. When i first started trt, i was on the test-hcg-ai combo. I did feel good for the first 3 weeks and then that tapered off. I assume it could be using the AI and or HCG with test before even getting my test dosage sorted out, juggling 3 drugs at once isnt exactly a cake walk.

I'm currently on test cyp only, 100mg split twice weekly. I'm 23 days into this protocol and so far not feeling great. Fellow TRTer's on the facebook forum said that my body is most likely adjusting and to reassess after 8 weeks, no changing anything.

My question is, how come test isnt working the same as it used to? Why did test work automatically when i did my first couple of cycles and now that im using test again, especially at more reasonable dosages and for medically purposes, its an absolute struggle?

Oh well, i gotta stay positive and hope overtime the answer comes to me through consistent dosing and bloodwork. Better yet, maybe my body does correct itself on test in the next month or so.

Like i said, i'll be back with blood work, I have bloodwork scheduled with quest on the 28th, the 6th week of my protocol.
 

Glockguy706

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When you cycled what ester did you use ace? The doctor should have you on follow up blood work and adjust your Ai based off of your estro levels . You may have crashed Estrogen or somthing. At 100 mg a week I doubt you need an AI but that is somthing to see your doctor about .
 

Glockguy706

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The low level your taking isnt going to make you feel like superman. 100 mg a week isnt going to make you feel like your on a gram of gear or a cycle .it's enough to restore some what of a normal level . I am on trt as well and take 200 mg test cyp a week and it puts my total test around 1000 and i feel normal but when I run a gram of test a week and my levels are over 3k I feel great.
 
DarkDescartes

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The low level your taking isnt going to make you feel like superman. 100 mg a week isnt going to make you feel like your on a gram of gear or a cycle .it's enough to restore some what of a normal level . I am on trt as well and take 200 mg test cyp a week and it puts my total test around 1000 and i feel normal but when I run a gram of test a week and my levels are over 3k I feel great.
I'm not expecting to feel like superman, I'm expecting to feel like a 26 year old man.

My libido and ED have been trash for the last 3 years. My cogintion is a step slower, low mood and my fatigue is a problem as well.

I'm usually a high responder but you may be right about the 100mg, you're not the first person to suggest that its too low, but i have to wait and see first.


I've blasted test before at cycle dosages and B&C and haven't gotten a libido boost at all.

Maybe the AI has messed with my e2 system and maybe i feel like **** on hcg personally, who knows.

I'll how my bloods look in a few weeks as well as seeing how i feel once week 8 comes along.
 
DarkDescartes

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When you cycled what ester did you use ace? The doctor should have you on follow up blood work and adjust your Ai based off of your estro levels . You may have crashed Estrogen or somthing. At 100 mg a week I doubt you need an AI but that is somthing to see your doctor about .
Test cyp the first time and test e the second time. 500mg split twice a week for 12 weeks. No hcg, no AI needed.
 
Godstrength

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Guys, if you actually read the post, you'd have all the info you need.

I've pcted after both test cycles. I didn't pct after superdrol, well i should say i thought i did. The guy who sold me superdrol said to come back and get pct products but knowing what i know now, it was bunk and just after the sale, letting me **** up my body for the sake of a measly commission.

I've done multiple restarts and the no avail, trt for life is my only route.

I dont really care about injecting for life, i accepted my fate and the bright side is being at youthful levels for my entire existence.

The problem is finding out why test isnt working the same. When i first started trt, i was on the test-hcg-ai combo. I did feel good for the first 3 weeks and then that tapered off. I assume it could be using the AI and or HCG with test before even getting my test dosage sorted out, juggling 3 drugs at once isnt exactly a cake walk.

I'm currently on test cyp only, 100mg split twice weekly. I'm 23 days into this protocol and so far not feeling great. Fellow TRTer's on the facebook forum said that my body is most likely adjusting and to reassess after 8 weeks, no changing anything.

My question is, how come test isnt working the same as it used to? Why did test work automatically when i did my first couple of cycles and now that im using test again, especially at more reasonable dosages and for medically purposes, its an absolute struggle?

Oh well, i gotta stay positive and hope overtime the answer comes to me through consistent dosing and bloodwork. Better yet, maybe my body does correct itself on test in the next month or so.

Like i said, i'll be back with blood work, I have bloodwork scheduled with quest on the 28th, the 6th week of my protocol.
You keep jumping on and off... You need to come off everything and go see a doctor... In your early 20s youre placing yourself in prime candidacy for trt FOR LIFE. It takes time for everything to balance itself out. If you're continuously starting and stopping hpta your body's prob screaming WTF. It doesnt know what's up and whats down anymore....

Something people may not understand... With test over time it stops working like it did in the beginning... Just like every other drug. Thats why true trt is meant to be what puts your body closest to natural levels... Which to me is between 6 and 800. Its not just a numbers game though. One person may feel great with total t of 500 amd for the next person it may be 900.

The short version of why it's not working like it did in the beginning is because your body is adapting to it.


How much test are you actually taking?
 
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DarkDescartes

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You keep jumping on and off... You need to come off everything and go see a doctor... In your early 20s youre placing yourself in prime candidacy for trt FOR LIFE. It takes time for everything to balance itself out. If you're continuously starting and stopping hpta your body's prob screaming WTF. It doesnt know what's up and whats down anymore....

Something people may not understand... With test over time it stops working like it did in the beginning... Just like every other drug. Thats why true trt is meant to be what puts your body closest to natural levels... Which to me is between 6 and 800. Its not just a numbers game though. One person may feel great with total t of 500 amd for the next person it may be 900.

The short version of why it's not working like it did in the beginning is because your body is adapting to it.
*Facepalm*

Do any of you guys fucking read what i write?!?!?!

Obviously you guys need a little more information.

The days of me being natty are GONE.

When i finished testosterone in 2016, i didnt do anything for 18 months, no supplements, nothing, just went about my life hoping my body corrects itself.

IT NEVER DID.

I then saw urologists and endos, did clomid and nolva, proviron, nothing.

I did hcg multiple times, my VERY first shot of hcg i felt pretty damn good, but it never worked again.

It was THEN i did trt.

I did hop on and off correct, i was hoping maybe there was still a chance to be natty with t3 being low, maybe if i fixed that everything could correct.

Never really did find a problem and it seems to slowly be increasing by itself anyway judging by my latest bloods in june where i got my free t3 up to 3.0.

I decided in May to fully commit to trt because i ALWAYS felt garbage natty, regardless. I believe im so supposed to be on trt.

Now im working on finding the right dose for myself. I've been tinkering with test too much and i have to admit its gonna be more of a marathon than a sprint.

I'll be back with blood work in November.

READ MY OP AND WHAT IVE WRITTEN CAREFULLY BEFORE COMMENTING.
 
SFreed

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You're first post was a train wreck of partial sentences that was difficult to read. Had it been structured like this last post, maybe you would have gotten better replies. So, don't be a dyck when people offer advice based on that first post.
 
DarkDescartes

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You're first post was a train wreck of partial sentences that was difficult to read. Had it been structured like this last post, maybe you would have gotten better replies. So, don't be a dyck when people offer advice based on that first post.
Well i'll say its my fault for giving the cliff notes and not the full story, however, i don't think anybody is trying to sit through a memoir either.

Guess I'll have to find a better way to shorten the story next time.

This is also apart of my problem, concentration. My patience and ability to sit through tasks, like writing a post, is less than ideal.

I'm trying to understand why i could take 250mg of test in my past cycle use and feel the beneficial effects immeditately, as opposed to the past few months, being unable to get that same boost at all should i induce the same dose.
 
SFreed

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I think your best bet is to discuss this with your Dr in November. Full disclosure. Tell them the whole story. I'm thinking the over time you've jacked yourself up pretty good and it's going to take time to fix it. I hope things turn out well for you
 
DarkDescartes

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I think your best bet is to discuss this with your Dr in November. Full disclosure. Tell them the whole story. I'm thinking the over time you've jacked yourself up pretty good and it's going to take time to fix it. I hope things turn out well for you
My doctor already knows my history and i haven't really been shy about it in the past.

Who knows, maybe i just need to keep a consistent dosage and my body works itself out.

Guess I'll be patient as hard as it is and wait this one out over the upcoming months.

Thanks guys!
 

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