Everyone does it differently, from once a week to once a day depending on your preference. If you're a high estrogen converter more frequent smaller doses help with estrogen spikes, I've tried it every which way and after trying them all I usually just do whatever is most convenient for me at the time. If I'm not getting any high estrogen side effects I'm just taking the whole shot once a week unless I'm running a cycle and then don't have a choice but to break it up because of oil volume