.....you can shoot HCG IM as well.
makes sense but i always thought the longer HL from SC would create less fluctuation...
the research echoes what one would expect...
this one says IM is more bioavailable, but the sampling time after administration isnt mentioned:
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but after 36 hours, more remains if administered SC:
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and this is the best one, which brings it all together:
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"Compared with IM administration of hCG, peak serum drug concentration was significantly delayed (P = 0.01) and serum half-life was prolonged (P = 0.01) after SC injection; however, T, LH, and FSH responses were identical."
bottom line? as you'd expect, SC shots last longer but produce lower peaks. now the question - which is actually better?
years ago PA had an idea about HCG not conforming to the pulsatile nature of LH and it should be used sparingly...i dont know if he meant that although leydig cells are stimulated to make T, the HPTA quits kicking out GnRH/LH, or the leydig cells become supersaturated by the constant flow of LH (unlike ARs which, despite being used to small pulses of T, can handle a steady stream which probably, to them, just seems like a higher concentration)...anywho, worth looking into.