Sustain Alpha

[strategicmove]

Hey I got to your PM first on these... but for everyone else...

Yes, scrotal apps are ok, and your plan sounds fine.

Excessive DHT should not be a concern if your on the Testosterone Recovery Stack since Toco-8 should be protecting your hair from any potential increase in DHT.

I wouldn’t add any additional ingredients to the topicals. They are maxed out as far as solubility goes.

Forskolin can be very estrogenic. In fact I personally get gyno symptoms when Im using it, and Ive also heard similar reports from others. It’s just not something we choose to work with, but yes there may be some cAMP synergy.

-Pp

Thank you.

 

[Jared]

Hey I got to your PM first on these... but for everyone else...

Yes, scrotal apps are ok, and your plan sounds fine.

Excessive DHT should not be a concern if your on the Testosterone Recovery Stack since Toco-8 should be protecting your hair from any potential increase in DHT.

I wouldn’t add any additional ingredients to the topicals. They are maxed out as far as solubility goes.

Forskolin can be very estrogenic. In fact I personally get gyno symptoms when Im using it, and Ive also heard similar reports from others. It’s just not something we choose to work with, but yes there may be some cAMP synergy.

-Pp

Any idea on the mechanism here, PP? I also experience estrogenic sides when using any compound containing foskohlii. I thought I was just a little crazy, but it shows up like clockwork everytime...painful little titties.

 

[strategicmove]

Any idea on the mechanism here, PP? I also experience estrogenic sides when using any compound containing foskohlii. I thought I was just a little crazy, but it shows up like clockwork everytime...painful little titties.

As it turns out, some flavones and isoflavones (polyphenolic phytochemicals belonging in the general class of flavoniods) that produce fat loss in animals may promote aromatase activity in humans. In particular, by elevating tissue cAMP levels through phosphodiestrase (PDE) inhibition, these flavones and isoflavones also stimulate aromatase activity in human gonads by increasing activity of cAMP-dependent alternative aromatase promoter enzymes p11 and 1.3. Usually, PDE metabolises cAMP. So PDE-inhibition boosts cAMP, leading to fat breakdown in adipose tissue. However, cAMP-boosting by these isoflavones and flavones also stimulates aromatise activity in some individuals. The isoflavone, genistein is a well known example. Forskolin, a well-known cAMP booster, appears to chart the same pathway in certain individuals.

 

[Jared]

As it turns out, some flavones and isoflavones (polyphenolic phytochemicals belonging in the general class of flavoniods) that produce fat loss in animals may promote aromatase activity in humans. In particular, by elevating tissue cAMP levels through phosphodiestrase (PDE) inhibition, these flavones and isoflavones also stimulate aromatase activity in human gonads by increasing activity of cAMP-dependent alternative aromatase promoter enzymes p11 and 1.3. Usually, PDE metabolises cAMP. So PDE-inhibition boosts cAMP, leading to fat breakdown in adipose tissue. However, cAMP-boosting by these isoflavones and flavones also stimulates aromatise activity in some individuals. The isoflavone, genistein is a well known example. Forskolin, a well-known cAMP booster, appears to chart the same pathway in certain individuals.

Thanks Strategic.
It's unfortunate that I react this way. It
really limits my supplement choices considering that most decent products contain Forslean in some shape or form.