the problem is that it improves your fat cells insulin sensitivity and you dont want that. „insulin sensitivity“ at all is some marketing shot most of the time. „nutrient partitioning“ with supplements is quite worthless.
after a training session your insulin sensitivity is up for several hours, its up IN the muscles. (to improve general insulin sensitivity you mustn’t be fat and you have to do sports - thats it)
berberin actives ampk, ampk tells the cell a low energy status. the cell afterwards wants to get nutrients, glucose out of the bloodstream. (a cell with low energy status doesnt want to do anything like proteine synthesis, just to show, why muscle hypertrophy + berberin do not well together)
so there are two possibilities:
- you improve the insulin sensitivity, which is anyway on a high level after training, with berberin but also inhibit protein synthesis
- or the ampk suppression through training balances the effect of berberin and ampk does not get increased - no effect in the muscles
the ampk activation works in the whole body! so if it isnt increased inside the muscles, it will still work inside the fat cells. gratulation, you made your fat cells more insulin sensitive. great idea - now the fat cells desire to store some nutrients.
Your hypothesis that fat cells shouldn't be sensitive to insulin is highly flawed for one thing. I DO want my fat cells, along with all my other fat cells, to be sensitive to insulin. Fat cells serve a function beyond energy storage, and they are part of the system as a whole. Insulin resistance in fat cells will contribute to systemic resistance. Sorry.
You do realize that exercise is one of the best ways to increase AMPK right?
I do like that you said Performax copied you, but yet you use caffeine and copy everyone else. L dopa in a sleep aid?
Get your own ideas, bruh!
Brah, I like, discovered this compound! I love how developers often forget that they are, at best, reading OTHER scientists' research and applying it - they didn't discover it. There could be studies of agmatine improving glucose tolerance going back to before any of us were born. Now, granted, if he is the first to find those studies and apply them to a partitioner...awesome. But still...
LCLT has multiple studies showing benefits. Are you claiming that the results of these studies are incorrect/flawed/etc? Also, are you not a fan of ALCAR? Granted, it has different uses that LCLT/PLCAR, but your post seems to indicate that you don’t think ALCAR is “Worth a damn,” as it was not mentioned with what you say are the only carnitines worth a damn. Is this true? Also, would you mind showing me the research showing that LCLT is “harmful to mitochondria.” Thanks in advance.
Those studies are all just pseudoscience. I get my research from the source. That source happens to be a bunch of people who have a disease that is not even recognized by many doctors....good ol' CFS. If someone with CFS says they are sick, you can take that sh1t to the bank.
i said arginocarn was good. i admit, i was being a little extreme. alcar is not useless, just not as good as arginocarn.
as for lclt, the best way is to google cfs/me (chronic fatigue syndrome/myalgic encephalomyelitis) and find post about carnitines and how they made people feel. lclt basically makes everyone worse while fumarate is of significant help. as the condition includes mitochondrial dysfunction (i am affected myself), these reports are more valuable to me than any study as it shows tartaric acid is something healthy peoply may tolerate but it is definitely not a good substance.
Can you explain to me what, "Mitochondrial Dysfunction" means? It seems like you're taking a disease that may not even really have a pathology, and then taking a specific chemical that people claim they "feel worse" when they take it, and making a lot of jumps here. The irony is the title of your thread is against companies making supplements using pseudoscience - and this is just way way counter to your original statement.
And to take a chemical and then say it is bad because a group of supposedly "sick" individuals can't tolerate it - that's a big leap in itself. Do you avoid all sources of phenylalanine too?
I'm seriously not trying to bash and you actually seem like a pretty smart guy, but you've got some leaps here...
olympus claims that their pomegranate and vaso6 are far superior to cop and amentoflavone though. this is simply inaccurate unless you consider strength gains the least relevant factor in performance enhancement. i havent seen anyone using the vaso6 or epicatechin+vaso6 having insane gains in strength and i have plenty of experience with pomegranate extract, standardized to punicallagins, not ellagic acid. and cop and amento in proper doses give far more strength, eventhough pomegranate is great for endurance and vaso6 may be too. the mistake here is considering cop and amento endurance supplements. 2g of cop and 160-240mg of amento do not increase my endurance, they increase the weight i can move instantly after the first dosage. especially amento, but the dose needs to be at least 160mg for me and people never got that. i thought conquer unleashed with cop and amento was great when it came out, such a good idea, despite me not agreeing that cholinergics are a good thing unless used in moderation. then they moved further and further away from their brilliant creation towards some weird stuff with 5!!!!! stims.
and no matter what is claimed, the sides people report are typical yohimbine type sides.
Amentoflavone seems to have not panned out for A LOT of people. One of the big effects people did notice from amento, I believe, is increased pump. Pomegranate juice should inhibit arginase....so that's maybe the area where it excels? Vasodilation? Not sure, haven't seen research on pomegranate juice having performance benefits beyond that, nor read the write-ups - just assuming that's probably a viable angle. We can debate if pumps are even useful...I don't use Pre's all that much. OL's pre's have been as good as any of the others I've tried though.
This thread is quite interesting, the part about dangerous stimulants/toxic piques my interest.
Let's just say a use of a certain supplement has pretty much made a big difference in my life, negatively. (Positively in terms of increasing focus I suppose)
So much so.. that I had withdrawal symptoms, even had to see a doctor and was diagnosed with something.
But as soon as I took a scoop, all "withdrawal" effects have gone away.
Now I'm basically taking it 2-3 times a week to get through my semester at college, so I don't perform any less than baseline.
Who knows.. maybe it was a phase, or maybe as soon as I discontinue usage, I will go back to experiencing the HORRIBLE withdrawal symptoms that I was experiencing for MONTHS.
That sucks man. That's a complex issue - not really sure it is 100% stim caused, but a lot of stims also have neurological effects including MAO inhibition, adenosine blockade, etc.
Have you had issues sleeping? Do you get a full night's sleep normally? Obviously not trying to pry, just seeing if something obvious pops out.
