SUP3R DHEA Q&A

NewAgeMayan

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It’s no secret, Prohormone cycles are extremely popular with those looking to increase muscle mass and strength, but as we all know, they come with certain drawbacks. Perhaps youve used such products before, only to experience these drawbacks firsthand.

Ask yourself, have you ever felt lethargic while on cycle? Have you ever felt that lethargy limited your ability to get the most out of your cycle? Perhaps you felt you could have pushed harder, seen better results, if only you had the energy? Or maybe youve never done a cycle, and the concerns regarding lethargy and low libido are holding you back, causing you to seek a solution to such issues before taking the next step. Well look no further, SUP3R-DHEA was designed specifically to UNLEASH your inner Demi-God, crush on cycle lethargy and take your workouts to the next level!



So what is SUP3R DHEA?


It is a premium quality transdermal product which can aid those seeking to reduce body fat, increase lean muscle mass and enhance performance! But most importantly, it helps keep the body hormonally balanced during a suppressive cycle. So how does SUP3R-DHEA do this? Well, while many people are under the impression that they fully understand the suppression of the HPTA that occurs while on cycle, one important aspect is often overlooked. When the HPTA is suppressed, its not only Testosterone, DHT and Estrogen that decline in production, but DHEA and Pregnenolone as well. These two hormones are just as vital to various physiological processes as Testosterone, DHT and Estrogen are! In fact, Endocrinologists frequently put men who are prescribed Testosterone-Replacement Therapy (TRT) on supplemental DHEA and Pregnenolone for this very reason! Thus, SUP3R-DHEA was formulated with this in mind.



So what does SUP3R-DHEA consist of?


Well, it’s primary ingredient is Dehydroepiandrosterone or DHEA, which is sometimes referred to by its synonyms androstenolone, dehydroepiandrostenedione or didehydroepiandrosterone and occasionally by its nomenclature 3ß-hydroxyandrost- 5-en- 17-one or 5-androsten-3ß- ol-17- one. It is a naturally occurring endogenous hormone, and in humans it is the most abundant hormone in circulation, where it is produced in the adrenal glands, the brain and the gonads. [1-4] It functions predominantly as a metabolic intermediate in the biosynthesis of the androgen and estrogen sex hormones. [1][5] But it also has a significant number of potential biological effects in its own right, such as binding to an array of nuclear and cell surface receptors and acting as a neurohormone. [6-7] Which, as a neurohormone, it has important effects on neurological and psychological functioning. [8-10]



Now, it would be tedious to attempt to cover DHEAs mechanisms of action in their entirety. With this in mind, the most important mechanism worth highlighting is its function as an endogenous precursor, or prohormone, to more potent androgens such as Testosterone and Dihydrotestosterone (DHT). [13] It also has the potential to convert to hormones such as 7-beta DHEA or 7-Keto DHEA which are associated with an increase in the rate of fat loss, while simultaneously aiding in muscle accretion. [15][23-27]

When DHEA is supplemented orally, not all of these effects and conversions are seen, as the digestive track does not have the same enzyme activity as the skin. [14] But when applied topically to the skin, which is highly concentrated with hormoneo enzymes, the potential for DHEA to convert to stronger hormones such as androstenediol, androstenedione and testosterone in greatly enhanced. [14-22]

Though DHEA has been noted to possess some degree of androgenic activity in its own right, with it acting as a low affinity weak partial agonist of the androgen receptor. There has even been speculation by some that DHEA can act as an anti-androgen due to its intrinsic activity at the receptor being quite weak and its competition for binding with full agonists like testosterone, potentially causing it to behave more like an antagonist depending on circulating Testosterone and Dihydrotestosterone (DHT) levels.

However, because its affinity for the receptor is very low it is unlikely to be of much significance under normal circumstances. [11-12] So such speculation can be disregarded.



But DHEA isn’t the only shining star, SUP3R-DHEA has yet another vital hormone in its formula Pregnenolone, which is also known as P5 and is sometimes referred to by its nomenclature 3ß-hydroxypregn-5- en-20- one. Like DHEA, it too is a naturally occurring endogenous hormone, and in fact is the precursor of the progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens, as well as the neuroactive hormoness. Though Pregnenolone is also biologically active in its own right, and acts as a powerful neurohormone which can potentially enhance both memory and focus. [28-30][40] This is because Pregnenolone, like DHEA, belongs to the group of neurohormoness that are found in high concentrations in certain areas of the brain. Neurohormones such as Pregnenolone affect synaptic functioning, are neuroprotective and enhance myelinization. It is under investigation for its potential to improve cognitive and memory functioning, [40] as well as being considered as a potential treatment for schizophrenia. [39]



And though DHEA and Pregnenolone fulfill many vital physiological needs, they both have the potential to convert to Estrogen. Now while Estrogen does play a role in anabolism, and fulfills vital physiological needs as well, too much can result in side effects. Because of this, SUP3R-DHEA was formulated with estrogen control in mind. Acacetin, which is sometimes referred to by its nomenclature 4-Methoxy- 5,7 dihydroxyflavone, is a natural O-methylated flavone found in Turnera Diffusa (Damiana) [41], Robinia Pseudoacacia (Black Locust), Betula Pendula (Silver Birch) [42], and in the fern Asplenium Normale. [43]

Researchers at the University of Mississippi performed a study aimed at investigating the anti-aromatase activity and estrogenic activity of constituents isolated from Turnera Diffusa. In the study, 24 compounds were isolated from the leaves of Turnera Diffusa and evaluated for aromatase activity by
using a tritiated-water release assay and for estrogenic activity by using yeast estrogen screen (YES)
assay. Among the compounds tested, Pinocembrin and Acacetin were shown to be the most potent
aromatase inhibitors. However, Pinocembrin was found to have estrogenic activity, while Acacetin
showed no estrogenic activity whatsoever. In the study, Acacetin was found to suppress aromatase
activity up to 63 percent. [41] This is important because aromatase is the enzyme required for conversion to Estrogen, which at excessive levels is associated with negative side effects such as bloating, increased water retention and gynecomastia. Thus, Acacetin helps to mitigate potential estrogenic side effects that may occur from DHEA or Pregnenolone supplementation.



The fourth and final component of SUP3R-DHEA is Osthole, which is sometimes referred to by its nomenclature 7-Methoxy- 8-(3- methyl-2- butenyl)coumarin or 7-Methoxy- 8-isopentenylcoumarin.

Osthole is a naturally occurring O-methylated coumarin found in plants such as Angelica Archangelica, Angelica Pubescens and Cnidium Monnieri. Like the other components of SUP3R-DHEA, Osthole has numerous effects. It is a calcium channel blocker, it dramatically decreased lipid accumulation in a quail model, and its neuroprotective effect on MPP(+)-induced cytotoxicity in PC12 cells supports the use of Osthole as a therapeutic agent for the treatment of neurodegenerative disorders.

Osthole is also an active constituent of Cnidium Monnieri, which has been used as a pro-erectile herb in traditional Chinese medicine, and appears to be able to cause pro-erectile muscular relaxation in a dose-dependent manner, [51-52] possibly via phosphodiesterase inhibition, as Osthole appears to potentiate cGMP induced relaxation as well as nitric oxide. [52] But there may be other possible mechanisms at work, such as central (brain) effects due to the ability to induce glutaminergic neurotransmission.

Another interesting ability of Osthole is that it is able to reduce fatty liver induced by alcohol, as well as induced by milk-fat [44][46-48], as well as lower triglyceride content in liver tissue [49], and induce PPAR alpha activation which can then reduce DGAT and HMG-CoA activity, resulting in a shift towards lipid mobilization rather than storage. [45] It also suppresses the mRNA transcription rates of Fatty Acid Synthase by 9.1%-38.7%, as well as suppresses the LDL receptor in the liver by 54.7%-78.9%. [49] It has been implicated in increasing AMPK-mediated glucose uptake into myocytes in dose and time dependent manners, with increases in glucose uptake via GLUT4 translocation induced by AMPK. [50]

Osthole may also phosphorylate (activate) Akt, as well as the downstream proteins of AS160 and GSK3, which is yet another mechanism by which GLUT4 may be increased. [50] Osthol also appears to be a mixed inducer of PPAR alpha and gamma activity [48], which is one of the mechanisms by which it protects against fatty liver. [45] PPAR alpha and PPAR gamma activation is a mechanism of fat loss in some supplements, thus Osthole holds potential as a fat loss agent.


super-dhea-ingredients.png
NB: 1 pump=2ml



Now that weve covered the individual ingredients, let’s delve into the formulation as a whole. One important aspect of SUP3R-DHEA is that none of its ingredients are methylated, so there is no need for liver support such as TUDCA while using SUP3R-DHEA because it is not hepatotoxic. And with its transdermal delivery system, it bypasses first-pass hepatic metabolism by going direct-to- bloodstream.

In fact, SUP3R-DHEA is perfect for transdermal delivery because all ingredients in its formulation conform to the 500 Dalton rule which states the molecular weight of a compound must be under 500 Dalton to allow skin absorption. And SUP3R-DHEA does exactly this, with Pregnenolone weighing 316.47g/mol, DHEA weighing 288.42g/mol, Acacetin weighing 284.26g/mol, and Osthole weighing 244.28g/mol. All known topical drugs used in transdermal drug-delivery systems are under 500 Dalton.

[53] Transdermal delivery also comes with the added benefit of releasing compounds slowly over a longer period of time, meaning blood levels wont rapidly peak and then dissipate as can be seen with oral administration. This translates to stable blood levels and better results.

But that’s not all! SUP3R DHEA delivers a jaw-dropping 12g DHEA, 6g Cnidium Monnieri Extract (3g being pure Osthole), 3g Pregnenolone and 3g Acacetin per bottle!

So as you can see, SUP3R-DHEA is a well-rounded, premium-quality transdermal product that has numerous benefits to anyone on cycle! Its effects go above and beyond just that of a simple Test Base mitigating the effects of lethargy brought on by prohormone and designer hormone use!




Effects of SUP3R-DHEA:


It is worth highlighting the numerous effects that SUP3R-DHEA has, and how it could be a beneficial addition to a cycle:

-Functions as a Test Base

-Provides Vital Hormones (For Various Physiological Functions)

-Improves Cognitive Abilities [31-32]

-Improves Libido/Sex Drive

-Improves Sleep Quality

-Improves Sense of Well-Being [33-34]

-Increases Stamina

-Increases Energy

-Mitigates Lethargy

-Enhanced Athletic Performance

-Enhances Strength

-Enhances Recovery [35-38]

-Aids in Estrogen Management



Side Effects of SUP3R-DHEA:


In regards to short term usage, several studies have shown that there are few adverse effects. In one study by Chang et al., DHEA was administered at a dosage of 200mg/day for a whopping 24 weeks with only slight androgenic effects noted. [54] Another study, which utilized dosages up to 400mg/day for 8 weeks, also resulted in few adverse events reported. [55] Therefore we can extrapolate that higher dosages and longer usage is both safe and relatively side effect free.

Though SUP3R-DHEA is designed to be used on-cycle when the HPTA is suppressed, it is worth stating that due to the hormones it can potentially convert to, SUP3R-DHEA can itself be suppressive as well.

This is of little concern for those stacking SUP3R-DHEA because it is intended to function as a Test Base, helping to mitigate lethargy, low libido, etc. And unlike other hormonal products, SUP3R-DHEA does not have a negative impact on cholesterol levels, the liver, the prostate or the heart.




Dosing, Cycle Length, Stacking and Timing:


SUP3R-DHEA is a very versatile product, and dosing can be adjusted as needed, though the general guidelines for dosing are as follows:


150-200lbs: 1 – 1.5 pumps with wrists on to dry skin only!

200-225lbs: 1.5 – 2 pumps with wrists on to dry skin only!

225lbs+: 2 – 2.5 pumps with wrists on to dry skin only!


(1 pump = 2mL)





SUP3R-DHEA is best utilized as a Test Base while using suppressive compounds on-cycle. It is typically used for 30-60 days, which is the traditional cycle length range. Because of its mild nature, it is considered to be a fantastic addition to all cycles. SUP3R-DHEA can be applied at any time during the day, either once or several times daily. As covered earlier, SUP3R-DHEA supplies DHEA and Pregnenolone due to natural production being suppressed on cycle, this is why it is often classified as a Test Base. However, it can be stacked with 4-Andro products such as SUP3R-4 and EpiAndro products such as SUP3R-EPI to fully supply all suppressed hormones, leading to optimal results while on cycle.​



Post-Cycle Therapy (PCT) for SUP3R-DHEA:


As stated earlier, due to the hormones SUP3R-DHEA can potentially convert to, it has the ability to be suppressive. Though it is formulated to be stacked with other suppressive compounds, which would require a proper PCT regardless, it must be noted that a PCT is recommended. Depending upon the cycle, and other suppressive compounds involved, the degree of PCT required will vary. It is best to follow the recommended guidelines for PCT listed under the product that SUP3R-DHEA is being utilized as a Test Base for. Those who are on Testosterone-Replacement Therapy (TRT) can use SUP3R-DHEA for extended periods of time due to their HPTA being shutdown indefinitely.





References:


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(1): 50–8. doi:10.1016/j.jsbmb.2005.11.011. PMID 16524719.

[2] William F Ganong MD, Review of Medical Physiology, 22nd Ed, McGraw Hill, 2005, page 362.

[3] The Merck Index, 13th Edition, 7798

[4] Schulman, Robert A.; Dean, Carolyn (2007). Solve It With Supplements. New York City: Rodale, Inc. p.100. ISBN 978-1- 57954-942- 8. ;DHEA (Dehydroepiandrosterone) is a common hormone produced in the
adrenal glands, the gonads, and the brain.;

[5] Thomas Scott (1996). Concise Encyclopedia Biology. Walter de Gruyter. p. 49. ISBN 978-3- 11-010661-9. Retrieved 25 May 2012.

[6] Webb SJ, Geoghegan TE, Prough RA, Michael Miller KK (2006). ;The biological actions of dehydroepiandrosterone involves multiple receptors;. Drug Metabolism Reviews 38 (1–2): 89–116.doi:10.1080/03602530600569877. PMC 2423429. PMID 16684650.

[7] Friess E, Schiffelholz T, Steckler T, Steiger A (December 2000). ;Dehydroepiandrosterone– a
neurohormone;. European Journal of Clinical Investigation. 30 Suppl 3: 46–50. doi:10.1046/j.1365 2362.2000.0300s3046.x. PMID 11281367.

[8] Abraham Weizman (1 February 2008). Neuroactive in Brain Function, Behavior and
Neuropsychiatric Disorders: Novel Strategies for Research and Treatment. Springer Science & Business Media. pp. 241–. ISBN 978-1- 4020-6854- 6.

[9] Achille G. Gravanis; Synthia H. Mellon (24 June 2011). Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis. John Wiley & Sons. pp. 349–. ISBN 978-3- 527-63397- 5.

[10] Sex difference in the human brain, their underpinnings and implications. Elsevier. 3 December 2010.p. 127–. ISBN 978-0- 444-53631- 0.

[11] Chen F, Knecht K, Birzin E; et al. (November 2005). ;Direct agonist/antagonist functions of
dehydroepiandrosterone;. Endocrinology 146 (11): 4568–76. doi:10.1210/en.2005-0368. PMID
15994348.

[12] Gao W, Bohl CE, Dalton JT (September 2005). ;Chemistry and structural biology of androgen
receptor;. Chemical Reviews 105 (9): 3352–70. doi:10.1021/cr020456u. PMC 2096617. PMID 16159155.

[13] Sex hormone Metabolism in Human Peripheral Blood Mononuclear Cells Changes with Aging The Journal of Clinical Endocrinology & Metabolism 90(11):6283-6289 (2005)

[14] Effects of transdermal application of DHEA to men on the levels of , gonadotropins and
lipids. SULCOVÁ J, et al. Physiol Res 49: 685-693, 2000.

[15] Transformation in vitro of [4-14C ] dehydroepiandrosterone into 7-oxygenated derivatives by the
normal human male and female skin tissue. Faredin, I., et al. J. Invest. Dermatol. 52:357. 1969

[16] High bioavailability of dehydroepiandrosterone administered percutaneously in the rat C Labrie, et al. Sep 1996; 150: S107 – S118.

[17] The metabolism of [4-14C] 5 androstene-3P, 17P-diol by normal human skin in vitro. Faredin, et al. Acta Med. Acad. Sci. Hung. 32:139. 1975.

[18] Sebocytes are the key regulators of androgen homeostasis in human skin. M Fritsch, et al. J Invest Dermatol, May 1, 2001; 116(5): 793-800.

[19] Transformation and conjugation of dehydroepiandrosterone by human skin. Berliner, D. L., et al. J. Clin.Endocrinol. 27:1214. 1967.

[20] The formation of water soluble s by human skin. Berliner, D. L., et al. J. Invest. Dermatol. 50:220. 1968

[21] The in vitro metabolism of dehydroepiandrosterone in human skin. I Faredin, et al.Acta Med Acad
Sci Hung, Jan 1967; 23(2): 169-79.

[22] The metabolism of [4-14C] dehydroepiandrosterone by human skin in vitro. I. Transformation in
vitro of [4-14C] dehydroepiandrosterone into Androst-4- ene-3,17- dione, testosterone and androsterone
by normal human male and female skin slices. I Faredin, et al. Acta Med Acad Sci Hung, Jan 1970; 27(1):95-102.

[23] Metabolism of dehydroepiandrosterone by rat liver in vitro: A liquid chromatographic mass spectrometric study. Marwah, A., et al. J. Chromatog. (2002). B 767, 285-299.

[24] induction of thermogenic enzymes in liver of rats treated with s derived from dehydroepiandrosterone. LARDY H, et al. Proc Natl Acad Sci USA 92: 6617-6619, 1995.

[25] A randomized, double blind, placebo controlled study of 3 – acetyl – 7 – oxo dehydroepiandrosterone in healthy overweight adults.Kalman, D., et al.(2000). Curr. Ther. Res. 61, 435-442.

[26] The effect of 7 – keto Naturalean on weight loss: A randomized, double blind placebo controlled
trial. Zenk, J., et al.(2002). Curr. Ther. Res. 63, 263-272.

[27] How short-term transdermal treatment of men with 7-oxo- dehydroepiandrosterone influence
thyroid function.R Hampl, et al.Physiol Res, Jan 2006; 55(1): 49-54.

[28] Novel brain function: biosynthesis and actions of neurons. K Tsutsui, et al. Neurosci
Res, Apr 2000; 36(4): 261-73.

[29] Individual differences in cognitive aging: implication of pregnenolone sulfate. W Mayo, et a. Prog Neurobiol, September 1, 2003; 71(1): 43-8.

[30] Memory-Enhancing Effects in Male Mice of Pregnenolone and Metabolically Derived from it. JF Flood, et a. PNAS, Mar 1992; 89: 1567.

[31] Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women. Casson PR, et al. Am J Obstet Gynecol. 169:1536-1539. 1993

[32] DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency
range. Friess E, et al. Am J Physiol 1995;268:E107-E113.

[33] DHEA attenuates catecholamine secretion from bovine adrenal chromaffin cells. PS Liu et a. J Biomed Sci, Mar 2004; 11(2): 200-5.

[34] An open- label dose- escalation trial of oral dehydroepiandrosterone tolerance and pharmacokinetics in patients with HIV disease. Dyner TS, et al J Acquir Immune Deficiency Syndrom 1993;6:459- 465.

[35] Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. Morales AJ, et al. J Clin Endocrinol Me tab 1994;78:1360- 1367.

[36] Anticortisols: Their Potential Usefulness. Baulieu, et al., Las Vegas , NV : Conference on Cortisol and Anti-Cortisols, 1997

[37] Androstenediol reduces the anti-inflammatory effects of restraint stress during wound healing. CC Head, et al. Brain Behav Immun, Nov 2006; 20(6): 590-6.

[38] Androstenetriol improves survival in a rodent model of traumatic shock. AC Marcu, et al. Resuscitation, December 1, 2006; 71(3): 379-86.

[39] Marx CE, Bradford DW, Hamer RM, et al. (September 2011). ;Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence;. Neuroscience 191: 78–90. doi:10.1016/j.neuroscience.2011.06.076. PMID 21756978.

[40] Vallée M, Mayo W, Le Moal M (November 2001). ;Role of pregnenolone, dehydroepiandrosterone
and their sulfate esters on learning and memory in cognitive aging;. Brain Research. Brain Research
Reviews 37 (1-3): 301–12. doi:10.1016/S0165-0173(01)00135- 7. PMID 11744095.

[41] Zhao, J; Dasmahapatra, AK; Khan, SI; Khan, IA (December 2008). ;Anti-aromatase activity of the constituents from damiana (Turnera diffusa);. Journal of Ethnopharmacology 120 (3): 387–393. doi:10.1016/j.jep.2008.09.016. PMID 18948180.

[42] Valkama, E; Salminen, J-P; Koricheva, J; Pihlaja, K. ;Changes in Leaf Trichomes and Epicuticular
Flavonoids during Leaf Development in Three Birch Taxa;. Annals of Botany 94: 233–242.
doi:10.1093/aob/mch131.

[43] UmiKalsom, Yusuf; Harborne, Jeffrey B. (1991). ;Flavonoid distribution in asplenioid ferns;.
Pertanika 14 (3): 297–300.

[44] Zhang J, et al Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative
stress . Phytother Res. (2011)

[45] Sun F, et al Osthol regulates hepatic PPAR alpha-mediated lipogenic gene expression in alcoholic fatty liver murine . Phytomedicine. (2010)

[46] Zhang Y, et al Therapeutic effect of osthole on hyperlipidemic fatty liver in rats . Acta Pharmacol Sin.(2007)

[47] Zhang Y, et al Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARalpha/gamma in fat milk-induced fatty liver rats . J Asian Nat Prod Res. (2008)

[48] Zhang Y, et al Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression . Planta Med. (2007)

[49] Du R, et al Osthol ameliorates fat milk-induced fatty liver in mice by regulation of hepatic sterol
regulatory element-binding protein-1c/2- mediated target gene expression . Eur J Pharmacol. (2011)

[50] Lee WH, et al Osthole enhances glucose uptake through activation of AMP-activated protein kinase
in skeletal muscle cells . J Agric Food Chem. (2011)

[51] Chen CY Computational screening and design of traditional Chinese medicine (TCM) to block
phosphodiesterase-5 . J Mol Graph Model. (2009)

[52] Chen J, et al Effect of the plant-extract osthole on the relaxation of rabbit corpus cavernosum tissue
in vitro . J Urol. (2000)

[53] Bos JD, Meinardi MM. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Exp Dermatol. 2000 Jun;9(3):165-9. (PMID: 10839713)

[54] Chang DM, Lan JL, Lin HY, Luo SF (2002). ;Dehydroepiandrosterone treatment of women with mild-to-moderate systemic lupus erythematosus: a multicenter randomized, double-blind, placebo-controlled trial;. Arthritis Rheum 46 (11): 2924–2927. doi:10.1002/art.10615. PMID 12428233.

[55] Rabkin JG, McElhiney MC, Rabkin R, McGrath PJ, Ferrando SJ (2006). ;Placebo-controlled trial of
dehydroepiandrosterone (DHEA) for treatment of nonmajor depression in patients with HIV/AIDS;. Am J
Psychiatry. 163 (1): 59–66. doi:10.1176/appi.ajp.163.1.59. PMID 16390890.
 

NewAgeMayan

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NB: This write-up was penned by OUK team member Hastur

I cannot take any credit for the hours of work and study that went into putting the OP together.
 

Dragoninho

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Wow! This looks really good!
A bit high dosed for my own opinion (not often you will hear that..) but I ca probably solve it with a syringe so this could be epic!
Nice work!
 

Dragoninho

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Do we got a estimated time for when we can see it in the shops?
 
Afi140

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Looks legit. Well done
 

hamdysayed

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Damn. Can't believe I'm so late to the party. That is sic!
i wouldn't have known if u didn't post that link lol.
how this compares to a test base like sup3r 4 ?
and can you combine both ?
 
Jebrook

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i wouldn't have known if u didn't post that link lol.
how this compares to a test base like sup3r 4 ?
and can you combine both ?
Yes you can combine both. Sup3r 4 will be more anabolic but the Sup3r DHEA will have a lot of health benefits as well.
 

hamdysayed

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Yes you can combine both. Sup3r 4 will be more anabolic but the Sup3r DHEA will have a lot of health benefits as well.
cos honestly even when I ran 4 andro with epistane i was lethargic still, hopefully this will be the solution.
 
rtmilburn

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cos honestly even when I ran 4 andro with epistane i was lethargic still, hopefully this will be the solution.
Good chance it will. Pregnenolone is awesome for energy and dhea will also help. 4dhea, epiandro, this, liver support, and CARBS, should cure most cases of lethargy.
 

hamdysayed

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Good chance it will. Pregnenolone is awesome for energy and dhea will also help. 4dhea, epiandro, this, liver support, and CARBS, should cure most cases of lethargy.
trenavar
epistane
4 andro
sup3r dhea
or too much ?
 

hamdysayed

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nice cos i wasn't ready for the lethargy
 
Jebrook

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My hat is off to our R&D guys. I've read the write-up several times now and just get more and more excited. Can't wait to get my hands on this:)
 

hamdysayed

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My hat is off to our R&D guys. I've read the write-up several times now and just get more and more excited. Can't wait to get my hands on this:)
any idea on the price point?
cos this current cycle cost me an arm and couple legs.
I'll run a sponsored log for yall if you want me to::D about to start tren on 1st and Epistane on 11th.
 

NewAgeMayan

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My hat is off to our R&D guys. I've read the write-up several times now and just get more and more excited. Can't wait to get my hands on this:)
Shout out to hastur, xtyler, and noaddedhmones!
 
Lucianooo

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It’s no secret, Prohormone cycles are extremely popular with those looking to increase muscle mass and strength, but as we all know, they come with certain drawbacks. Perhaps youve used such products before, only to experience these drawbacks firsthand.

Ask yourself, have you ever felt lethargic while on cycle? Have you ever felt that lethargy limited your ability to get the most out of your cycle? Perhaps you felt you could have pushed harder, seen better results, if only you had the energy? Or maybe youve never done a cycle, and the concerns regarding lethargy and low libido are holding you back, causing you to seek a solution to such issues before taking the next step. Well look no further, SUP3R-DHEA was designed specifically to UNLEASH your inner Demi-God, crush on cycle lethargy and take your workouts to the next level!



So what is SUP3R DHEA?


It is a premium quality transdermal product which can aid those seeking to reduce body fat, increase lean muscle mass and enhance performance! But most importantly, it helps keep the body hormonally balanced during a suppressive cycle. So how does SUP3R-DHEA do this? Well, while many people are under the impression that they fully understand the suppression of the HPTA that occurs while on cycle, one important aspect is often overlooked. When the HPTA is suppressed, its not only Testosterone, DHT and Estrogen that decline in production, but DHEA and Pregnenolone as well. These two hormones are just as vital to various physiological processes as Testosterone, DHT and Estrogen are! In fact, Endocrinologists frequently put men who are prescribed Testosterone-Replacement Therapy (TRT) on supplemental DHEA and Pregnenolone for this very reason! Thus, SUP3R-DHEA was formulated with this in mind.



So what does SUP3R-DHEA consist of?


Well, it’s primary ingredient is Dehydroepiandrosterone or DHEA, which is sometimes referred to by its synonyms androstenolone, dehydroepiandrostenedione or didehydroepiandrosterone and occasionally by its nomenclature 3ß-hydroxyandrost- 5-en- 17-one or 5-androsten-3ß- ol-17- one. It is a naturally occurring endogenous hormone, and in humans it is the most abundant hormone in circulation, where it is produced in the adrenal glands, the brain and the gonads. [1-4] It functions predominantly as a metabolic intermediate in the biosynthesis of the androgen and estrogen sex hormones. [1][5] But it also has a significant number of potential biological effects in its own right, such as binding to an array of nuclear and cell surface receptors and acting as a neurohormone. [6-7] Which, as a neurohormone, it has important effects on neurological and psychological functioning. [8-10]



Now, it would be tedious to attempt to cover DHEAs mechanisms of action in their entirety. With this in mind, the most important mechanism worth highlighting is its function as an endogenous precursor, or prohormone, to more potent androgens such as Testosterone and Dihydrotestosterone (DHT). [13] It also has the potential to convert to hormones such as 7-beta DHEA or 7-Keto DHEA which are associated with an increase in the rate of fat loss, while simultaneously aiding in muscle accretion. [15][23-27]

When DHEA is supplemented orally, not all of these effects and conversions are seen, as the digestive track does not have the same enzyme activity as the skin. [14] But when applied topically to the skin, which is highly concentrated with hormoneo enzymes, the potential for DHEA to convert to stronger hormones such as androstenediol, androstenedione and testosterone in greatly enhanced. [14-22]

Though DHEA has been noted to possess some degree of androgenic activity in its own right, with it acting as a low affinity weak partial agonist of the androgen receptor. There has even been speculation by some that DHEA can act as an anti-androgen due to its intrinsic activity at the receptor being quite weak and its competition for binding with full agonists like testosterone, potentially causing it to behave more like an antagonist depending on circulating Testosterone and Dihydrotestosterone (DHT) levels.

However, because its affinity for the receptor is very low it is unlikely to be of much significance under normal circumstances. [11-12] So such speculation can be disregarded.



But DHEA isn’t the only shining star, SUP3R-DHEA has yet another vital hormone in its formula Pregnenolone, which is also known as P5 and is sometimes referred to by its nomenclature 3ß-hydroxypregn-5- en-20- one. Like DHEA, it too is a naturally occurring endogenous hormone, and in fact is the precursor of the progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens, as well as the neuroactive hormoness. Though Pregnenolone is also biologically active in its own right, and acts as a powerful neurohormone which can potentially enhance both memory and focus. [28-30][40] This is because Pregnenolone, like DHEA, belongs to the group of neurohormoness that are found in high concentrations in certain areas of the brain. Neurohormones such as Pregnenolone affect synaptic functioning, are neuroprotective and enhance myelinization. It is under investigation for its potential to improve cognitive and memory functioning, [40] as well as being considered as a potential treatment for schizophrenia. [39]



And though DHEA and Pregnenolone fulfill many vital physiological needs, they both have the potential to convert to Estrogen. Now while Estrogen does play a role in anabolism, and fulfills vital physiological needs as well, too much can result in side effects. Because of this, SUP3R-DHEA was formulated with estrogen control in mind. Acacetin, which is sometimes referred to by its nomenclature 4-Methoxy- 5,7 dihydroxyflavone, is a natural O-methylated flavone found in Turnera Diffusa (Damiana) [41], Robinia Pseudoacacia (Black Locust), Betula Pendula (Silver Birch) [42], and in the fern Asplenium Normale. [43]

Researchers at the University of Mississippi performed a study aimed at investigating the anti-aromatase activity and estrogenic activity of constituents isolated from Turnera Diffusa. In the study, 24 compounds were isolated from the leaves of Turnera Diffusa and evaluated for aromatase activity by
using a tritiated-water release assay and for estrogenic activity by using yeast estrogen screen (YES)
assay. Among the compounds tested, Pinocembrin and Acacetin were shown to be the most potent
aromatase inhibitors. However, Pinocembrin was found to have estrogenic activity, while Acacetin
showed no estrogenic activity whatsoever. In the study, Acacetin was found to suppress aromatase
activity up to 63 percent. [41] This is important because aromatase is the enzyme required for conversion to Estrogen, which at excessive levels is associated with negative side effects such as bloating, increased water retention and gynecomastia. Thus, Acacetin helps to mitigate potential estrogenic side effects that may occur from DHEA or Pregnenolone supplementation.



The fourth and final component of SUP3R-DHEA is Osthole, which is sometimes referred to by its nomenclature 7-Methoxy- 8-(3- methyl-2- butenyl)coumarin or 7-Methoxy- 8-isopentenylcoumarin.

Osthole is a naturally occurring O-methylated coumarin found in plants such as Angelica Archangelica, Angelica Pubescens and Cnidium Monnieri. Like the other components of SUP3R-DHEA, Osthole has numerous effects. It is a calcium channel blocker, it dramatically decreased lipid accumulation in a quail model, and its neuroprotective effect on MPP(+)-induced cytotoxicity in PC12 cells supports the use of Osthole as a therapeutic agent for the treatment of neurodegenerative disorders.

Osthole is also an active constituent of Cnidium Monnieri, which has been used as a pro-erectile herb in traditional Chinese medicine, and appears to be able to cause pro-erectile muscular relaxation in a dose-dependent manner, [51-52] possibly via phosphodiesterase inhibition, as Osthole appears to potentiate cGMP induced relaxation as well as nitric oxide. [52] But there may be other possible mechanisms at work, such as central (brain) effects due to the ability to induce glutaminergic neurotransmission.

Another interesting ability of Osthole is that it is able to reduce fatty liver induced by alcohol, as well as induced by milk-fat [44][46-48], as well as lower triglyceride content in liver tissue [49], and induce PPAR alpha activation which can then reduce DGAT and HMG-CoA activity, resulting in a shift towards lipid mobilization rather than storage. [45] It also suppresses the mRNA transcription rates of Fatty Acid Synthase by 9.1%-38.7%, as well as suppresses the LDL receptor in the liver by 54.7%-78.9%. [49] It has been implicated in increasing AMPK-mediated glucose uptake into myocytes in dose and time dependent manners, with increases in glucose uptake via GLUT4 translocation induced by AMPK. [50]

Osthole may also phosphorylate (activate) Akt, as well as the downstream proteins of AS160 and GSK3, which is yet another mechanism by which GLUT4 may be increased. [50] Osthol also appears to be a mixed inducer of PPAR alpha and gamma activity [48], which is one of the mechanisms by which it protects against fatty liver. [45] PPAR alpha and PPAR gamma activation is a mechanism of fat loss in some supplements, thus Osthole holds potential as a fat loss agent.


NB: 1 pump=2ml



Now that weve covered the individual ingredients, let’s delve into the formulation as a whole. One important aspect of SUP3R-DHEA is that none of its ingredients are methylated, so there is no need for liver support such as TUDCA while using SUP3R-DHEA because it is not hepatotoxic. And with its transdermal delivery system, it bypasses first-pass hepatic metabolism by going direct-to- bloodstream.

In fact, SUP3R-DHEA is perfect for transdermal delivery because all ingredients in its formulation conform to the 500 Dalton rule which states the molecular weight of a compound must be under 500 Dalton to allow skin absorption. And SUP3R-DHEA does exactly this, with Pregnenolone weighing 316.47g/mol, DHEA weighing 288.42g/mol, Acacetin weighing 284.26g/mol, and Osthole weighing 244.28g/mol. All known topical drugs used in transdermal drug-delivery systems are under 500 Dalton.

[53] Transdermal delivery also comes with the added benefit of releasing compounds slowly over a longer period of time, meaning blood levels wont rapidly peak and then dissipate as can be seen with oral administration. This translates to stable blood levels and better results.

But that’s not all! SUP3R DHEA delivers a jaw-dropping 12g DHEA, 6g Cnidium Monnieri Extract (3g being pure Osthole), 3g Pregnenolone and 3g Acacetin per bottle!

So as you can see, SUP3R-DHEA is a well-rounded, premium-quality transdermal product that has numerous benefits to anyone on cycle! Its effects go above and beyond just that of a simple Test Base mitigating the effects of lethargy brought on by prohormone and designer hormone use!




Effects of SUP3R-DHEA:


It is worth highlighting the numerous effects that SUP3R-DHEA has, and how it could be a beneficial addition to a cycle:

-Functions as a Test Base

-Provides Vital Hormones (For Various Physiological Functions)

-Improves Cognitive Abilities [31-32]

-Improves Libido/Sex Drive

-Improves Sleep Quality

-Improves Sense of Well-Being [33-34]

-Increases Stamina

-Increases Energy

-Mitigates Lethargy

-Enhanced Athletic Performance

-Enhances Strength

-Enhances Recovery [35-38]

-Aids in Estrogen Management



Side Effects of SUP3R-DHEA:


In regards to short term usage, several studies have shown that there are few adverse effects. In one study by Chang et al., DHEA was administered at a dosage of 200mg/day for a whopping 24 weeks with only slight androgenic effects noted. [54] Another study, which utilized dosages up to 400mg/day for 8 weeks, also resulted in few adverse events reported. [55] Therefore we can extrapolate that higher dosages and longer usage is both safe and relatively side effect free.

Though SUP3R-DHEA is designed to be used on-cycle when the HPTA is suppressed, it is worth stating that due to the hormones it can potentially convert to, SUP3R-DHEA can itself be suppressive as well.

This is of little concern for those stacking SUP3R-DHEA because it is intended to function as a Test Base, helping to mitigate lethargy, low libido, etc. And unlike other hormonal products, SUP3R-DHEA does not have a negative impact on cholesterol levels, the liver, the prostate or the heart.




Dosing, Cycle Length, Stacking and Timing:


SUP3R-DHEA is a very versatile product, and dosing can be adjusted as needed, though the general guidelines for dosing are as follows:


150-200lbs: 1 – 1.5 pumps with wrists on to dry skin only!

200-225lbs: 1.5 – 2 pumps with wrists on to dry skin only!

225lbs+: 2 – 2.5 pumps with wrists on to dry skin only!


(1 pump = 2mL)





SUP3R-DHEA is best utilized as a Test Base while using suppressive compounds on-cycle. It is typically used for 30-60 days, which is the traditional cycle length range. Because of its mild nature, it is considered to be a fantastic addition to all cycles. SUP3R-DHEA can be applied at any time during the day, either once or several times daily. As covered earlier, SUP3R-DHEA supplies DHEA and Pregnenolone due to natural production being suppressed on cycle, this is why it is often classified as a Test Base. However, it can be stacked with 4-Andro products such as SUP3R-4 and EpiAndro products such as SUP3R-EPI to fully supply all suppressed hormones, leading to optimal results while on cycle.​



Post-Cycle Therapy (PCT) for SUP3R-DHEA:


As stated earlier, due to the hormones SUP3R-DHEA can potentially convert to, it has the ability to be suppressive. Though it is formulated to be stacked with other suppressive compounds, which would require a proper PCT regardless, it must be noted that a PCT is recommended. Depending upon the cycle, and other suppressive compounds involved, the degree of PCT required will vary. It is best to follow the recommended guidelines for PCT listed under the product that SUP3R-DHEA is being utilized as a Test Base for. Those who are on Testosterone-Replacement Therapy (TRT) can use SUP3R-DHEA for extended periods of time due to their HPTA being shutdown indefinitely.





References:


[1] Mo Q, Lu SF, Simon NG (April 2006). ;Dehydroepiandrosterone and its metabolites: differential effects on androgen receptor trafficking and transcriptional activity;. J. hormone Biochem. Mol. Biol. 99

(1): 50–8. doi:10.1016/j.jsbmb.2005.11.011. PMID 16524719.

[2] William F Ganong MD, Review of Medical Physiology, 22nd Ed, McGraw Hill, 2005, page 362.

[3] The Merck Index, 13th Edition, 7798

[4] Schulman, Robert A.; Dean, Carolyn (2007). Solve It With Supplements. New York City: Rodale, Inc. p.100. ISBN 978-1- 57954-942- 8. ;DHEA (Dehydroepiandrosterone) is a common hormone produced in the
adrenal glands, the gonads, and the brain.;

[5] Thomas Scott (1996). Concise Encyclopedia Biology. Walter de Gruyter. p. 49. ISBN 978-3- 11-010661-9. Retrieved 25 May 2012.

[6] Webb SJ, Geoghegan TE, Prough RA, Michael Miller KK (2006). ;The biological actions of dehydroepiandrosterone involves multiple receptors;. Drug Metabolism Reviews 38 (1–2): 89–116.doi:10.1080/03602530600569877. PMC 2423429. PMID 16684650.

[7] Friess E, Schiffelholz T, Steckler T, Steiger A (December 2000). ;Dehydroepiandrosterone– a
neurohormone;. European Journal of Clinical Investigation. 30 Suppl 3: 46–50. doi:10.1046/j.1365 2362.2000.0300s3046.x. PMID 11281367.

[8] Abraham Weizman (1 February 2008). Neuroactive in Brain Function, Behavior and
Neuropsychiatric Disorders: Novel Strategies for Research and Treatment. Springer Science & Business Media. pp. 241–. ISBN 978-1- 4020-6854- 6.

[9] Achille G. Gravanis; Synthia H. Mellon (24 June 2011). Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis. John Wiley & Sons. pp. 349–. ISBN 978-3- 527-63397- 5.

[10] Sex difference in the human brain, their underpinnings and implications. Elsevier. 3 December 2010.p. 127–. ISBN 978-0- 444-53631- 0.

[11] Chen F, Knecht K, Birzin E; et al. (November 2005). ;Direct agonist/antagonist functions of
dehydroepiandrosterone;. Endocrinology 146 (11): 4568–76. doi:10.1210/en.2005-0368. PMID
15994348.

[12] Gao W, Bohl CE, Dalton JT (September 2005). ;Chemistry and structural biology of androgen
receptor;. Chemical Reviews 105 (9): 3352–70. doi:10.1021/cr020456u. PMC 2096617. PMID 16159155.

[13] Sex hormone Metabolism in Human Peripheral Blood Mononuclear Cells Changes with Aging The Journal of Clinical Endocrinology & Metabolism 90(11):6283-6289 (2005)

[14] Effects of transdermal application of DHEA to men on the levels of , gonadotropins and
lipids. SULCOVÁ J, et al. Physiol Res 49: 685-693, 2000.

[15] Transformation in vitro of [4-14C ] dehydroepiandrosterone into 7-oxygenated derivatives by the
normal human male and female skin tissue. Faredin, I., et al. J. Invest. Dermatol. 52:357. 1969

[16] High bioavailability of dehydroepiandrosterone administered percutaneously in the rat C Labrie, et al. Sep 1996; 150: S107 – S118.

[17] The metabolism of [4-14C] 5 androstene-3P, 17P-diol by normal human skin in vitro. Faredin, et al. Acta Med. Acad. Sci. Hung. 32:139. 1975.

[18] Sebocytes are the key regulators of androgen homeostasis in human skin. M Fritsch, et al. J Invest Dermatol, May 1, 2001; 116(5): 793-800.

[19] Transformation and conjugation of dehydroepiandrosterone by human skin. Berliner, D. L., et al. J. Clin.Endocrinol. 27:1214. 1967.

[20] The formation of water soluble s by human skin. Berliner, D. L., et al. J. Invest. Dermatol. 50:220. 1968

[21] The in vitro metabolism of dehydroepiandrosterone in human skin. I Faredin, et al.Acta Med Acad
Sci Hung, Jan 1967; 23(2): 169-79.

[22] The metabolism of [4-14C] dehydroepiandrosterone by human skin in vitro. I. Transformation in
vitro of [4-14C] dehydroepiandrosterone into Androst-4- ene-3,17- dione, testosterone and androsterone
by normal human male and female skin slices. I Faredin, et al. Acta Med Acad Sci Hung, Jan 1970; 27(1):95-102.

[23] Metabolism of dehydroepiandrosterone by rat liver in vitro: A liquid chromatographic mass spectrometric study. Marwah, A., et al. J. Chromatog. (2002). B 767, 285-299.

[24] induction of thermogenic enzymes in liver of rats treated with s derived from dehydroepiandrosterone. LARDY H, et al. Proc Natl Acad Sci USA 92: 6617-6619, 1995.

[25] A randomized, double blind, placebo controlled study of 3 – acetyl – 7 – oxo dehydroepiandrosterone in healthy overweight adults.Kalman, D., et al.(2000). Curr. Ther. Res. 61, 435-442.

[26] The effect of 7 – keto Naturalean on weight loss: A randomized, double blind placebo controlled
trial. Zenk, J., et al.(2002). Curr. Ther. Res. 63, 263-272.

[27] How short-term transdermal treatment of men with 7-oxo- dehydroepiandrosterone influence
thyroid function.R Hampl, et al.Physiol Res, Jan 2006; 55(1): 49-54.

[28] Novel brain function: biosynthesis and actions of neurons. K Tsutsui, et al. Neurosci
Res, Apr 2000; 36(4): 261-73.

[29] Individual differences in cognitive aging: implication of pregnenolone sulfate. W Mayo, et a. Prog Neurobiol, September 1, 2003; 71(1): 43-8.

[30] Memory-Enhancing Effects in Male Mice of Pregnenolone and Metabolically Derived from it. JF Flood, et a. PNAS, Mar 1992; 89: 1567.

[31] Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women. Casson PR, et al. Am J Obstet Gynecol. 169:1536-1539. 1993

[32] DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency
range. Friess E, et al. Am J Physiol 1995;268:E107-E113.

[33] DHEA attenuates catecholamine secretion from bovine adrenal chromaffin cells. PS Liu et a. J Biomed Sci, Mar 2004; 11(2): 200-5.

[34] An open- label dose- escalation trial of oral dehydroepiandrosterone tolerance and pharmacokinetics in patients with HIV disease. Dyner TS, et al J Acquir Immune Deficiency Syndrom 1993;6:459- 465.

[35] Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age. Morales AJ, et al. J Clin Endocrinol Me tab 1994;78:1360- 1367.

[36] Anticortisols: Their Potential Usefulness. Baulieu, et al., Las Vegas , NV : Conference on Cortisol and Anti-Cortisols, 1997

[37] Androstenediol reduces the anti-inflammatory effects of restraint stress during wound healing. CC Head, et al. Brain Behav Immun, Nov 2006; 20(6): 590-6.

[38] Androstenetriol improves survival in a rodent model of traumatic shock. AC Marcu, et al. Resuscitation, December 1, 2006; 71(3): 379-86.

[39] Marx CE, Bradford DW, Hamer RM, et al. (September 2011). ;Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence;. Neuroscience 191: 78–90. doi:10.1016/j.neuroscience.2011.06.076. PMID 21756978.

[40] Vallée M, Mayo W, Le Moal M (November 2001). ;Role of pregnenolone, dehydroepiandrosterone
and their sulfate esters on learning and memory in cognitive aging;. Brain Research. Brain Research
Reviews 37 (1-3): 301–12. doi:10.1016/S0165-0173(01)00135- 7. PMID 11744095.

[41] Zhao, J; Dasmahapatra, AK; Khan, SI; Khan, IA (December 2008). ;Anti-aromatase activity of the constituents from damiana (Turnera diffusa);. Journal of Ethnopharmacology 120 (3): 387–393. doi:10.1016/j.jep.2008.09.016. PMID 18948180.

[42] Valkama, E; Salminen, J-P; Koricheva, J; Pihlaja, K. ;Changes in Leaf Trichomes and Epicuticular
Flavonoids during Leaf Development in Three Birch Taxa;. Annals of Botany 94: 233–242.
doi:10.1093/aob/mch131.

[43] UmiKalsom, Yusuf; Harborne, Jeffrey B. (1991). ;Flavonoid distribution in asplenioid ferns;.
Pertanika 14 (3): 297–300.

[44] Zhang J, et al Osthole improves alcohol-induced fatty liver in mice by reduction of hepatic oxidative
stress . Phytother Res. (2011)

[45] Sun F, et al Osthol regulates hepatic PPAR alpha-mediated lipogenic gene expression in alcoholic fatty liver murine . Phytomedicine. (2010)

[46] Zhang Y, et al Therapeutic effect of osthole on hyperlipidemic fatty liver in rats . Acta Pharmacol Sin.(2007)

[47] Zhang Y, et al Osthole regulates enzyme protein expression of CYP7A1 and DGAT2 via activation of PPARalpha/gamma in fat milk-induced fatty liver rats . J Asian Nat Prod Res. (2008)

[48] Zhang Y, et al Osthole improves fat milk-induced fatty liver in rats: modulation of hepatic PPAR-alpha/gamma-mediated lipogenic gene expression . Planta Med. (2007)

[49] Du R, et al Osthol ameliorates fat milk-induced fatty liver in mice by regulation of hepatic sterol
regulatory element-binding protein-1c/2- mediated target gene expression . Eur J Pharmacol. (2011)

[50] Lee WH, et al Osthole enhances glucose uptake through activation of AMP-activated protein kinase
in skeletal muscle cells . J Agric Food Chem. (2011)

[51] Chen CY Computational screening and design of traditional Chinese medicine (TCM) to block
phosphodiesterase-5 . J Mol Graph Model. (2009)

[52] Chen J, et al Effect of the plant-extract osthole on the relaxation of rabbit corpus cavernosum tissue
in vitro . J Urol. (2000)

[53] Bos JD, Meinardi MM. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Exp Dermatol. 2000 Jun;9(3):165-9. (PMID: 10839713)

[54] Chang DM, Lan JL, Lin HY, Luo SF (2002). ;Dehydroepiandrosterone treatment of women with mild-to-moderate systemic lupus erythematosus: a multicenter randomized, double-blind, placebo-controlled trial;. Arthritis Rheum 46 (11): 2924–2927. doi:10.1002/art.10615. PMID 12428233.

[55] Rabkin JG, McElhiney MC, Rabkin R, McGrath PJ, Ferrando SJ (2006). ;Placebo-controlled trial of
dehydroepiandrosterone (DHEA) for treatment of nonmajor depression in patients with HIV/AIDS;. Am J
Psychiatry. 163 (1): 59–66. doi:10.1176/appi.ajp.163.1.59. PMID 16390890.
Awesome!
 
solidsnake

solidsnake

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Big thanks to Jebrook for letting me know it had been posted? looks like great stuff! If the price ain't too hefty this could do a serious dent in dermacrines pocket! I'll defo be getting some!
 

GNO

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My hat is off to our R&D guys. I've read the write-up several times now and just get more and more excited. Can't wait to get my hands on this:)
Indeed, stellar job by our formulators :stooges:
 

crowbar46

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Nice job! I assume if one wanted to do a light "feel good" cycle of say LJ-100 and this for 12 weeks, it would only require a light PCT?

Crowbar
 

NewAgeMayan

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Nice job! I assume if one wanted to do a light "feel good" cycle of say LJ-100 and this for 12 weeks, it would only require a light PCT?

Crowbar
Yip. It may not be necessary, of course.
 
Tank999

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Ok, now you got me excited - I'm planning a sup3r 1/ep/11k 8 week run. Should I add this to really keeel it? Recomp is the goal...
 

NewAgeMayan

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Ok, now you got me excited - I'm planning a sup3r 1/ep/11k 8 week run. Should I add this to really keeel it? Recomp is the goal...
For sure, each product/compound would add something unique to it, to the cycle.

Dosing the epiandro all pre wo could really emphasise its CNS/strength capacity, whilst the SUP3R-DHEA provides more general and sustained relief from lethargy.
 
Tank999

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......, whilst the SUP3R-DHEA provides more general and sustained relief from lethargy.
Good to hear - on my first andro run the lethargy had me almost falling asleep at work - if this could help solve that it would be great!
 
Sparkss

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Just in time for labor day?
 
hiimnotcool

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Hmmm...looks like this is a good replacement for Dermacrine on cycle. I was thinking of bridging my 8week cycle of Sup3r-11 (1 bottle is lasting 8 weeks amazingly) into a 6 week epistane cycle. Will probably add this as a test base. With the labor day sale coming I'll obviously be able to get Ar1macare PRO and Sup3r PCT on the cheap too.
 
Lynks8

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Hmmm...looks like this is a good replacement for Dermacrine on cycle. I was thinking of bridging my 8week cycle of Sup3r-11 (1 bottle is lasting 8 weeks amazingly) into a 6 week epistane cycle. Will probably add this as a test base. With the labor day sale coming I'll obviously be able to get Ar1macare PRO and Sup3r PCT on the cheap too.
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The_Old_Guy

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Hmmm...looks like this is a good replacement for Dermacrine on cycle.
I read the first two ingredients and thought "Dermacrine?"

DHEA 72mg **
7,8-Benzoflavone (99%) 36mg **
Resveratrol (99%) 36mg **
Pregnenolone 18mg **
Chrysin (99%) 9mg **
**(DV)Daily Value Not Established

Other Ingredients: Water, ethyl alcohol (organic), dimethyl isosorbide, ethoxydiglycol, propylene glycol monolaurate, Dehydroepiandrosterone (DHEA), Trans-resveratrol (98%), 7,8,benzoflavone (98%), tiethanolamine, carbomer, pregnenelone, tetrahydropiperine.
Super-DHEA has more of the mains:
 

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Toren

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Hmm. Interesting.

Smart way to incease the portfolio.
 
The_Old_Guy

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Hmm. Interesting.

Smart way to incease the portfolio.
Yes, but saying stuff like "Yeah, 11-KT and 2-Andro are gone.... but just WAIT until you see Super-DHEA!" - was a little over-enthusiastic if you ask me :D Glad to have alternatives though - have to look at Osthole and Acacetin effectiveness in people for my next research project... Resveratrol has a lot of people data.
 
Woody

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Yes, but saying stuff like "Yeah, 11-KT and 2-Andro are gone.... but just WAIT until you see Super-DHEA!" - was a little over-enthusiastic if you ask me :D Glad to have alternatives though - have to look at Osthole and Acacetin effectiveness in people for my next research project... Resveratrol has a lot of people data.
Your presumption relies on a fatal assumption: that this is our only new release.
 
Jebrook

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Yes, but saying stuff like "Yeah, 11-KT and 2-Andro are gone.... but just WAIT until you see Super-DHEA!" - was a little over-enthusiastic if you ask me :D Glad to have alternatives though - have to look at Osthole and Acacetin effectiveness in people for my next research project... Resveratrol has a lot of people data.
No one down-played anything or over-hyped anything. There were several threads discussing the lineup changes weeks ago. Old news. And all in the best interest of our company.
 
NoAddedHmones

NoAddedHmones

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Yes, but saying stuff like "Yeah, 11-KT and 2-Andro are gone.... but just WAIT until you see Super-DHEA!" - was a little over-enthusiastic if you ask me :D Glad to have alternatives though - have to look at Osthole and Acacetin effectiveness in people for my next research project... Resveratrol has a lot of people data.
You really like making up imaginary stories and drama...

- noaddedhmones
 
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The_Old_Guy

The_Old_Guy

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You really like making up imaginary stories and drama...

- noaddedhmones
What did I make up? I have a pretty good memory, and remember something along the lines of "Be on the lookout for Super-DHEA!" (paraphrased as I don't feel like searching a million posts). Compared to 1, 2, 4, 11, and Epi DHEA offerings, much less SARMs, it's not as earth shattering as anticipated - and that's only my opinion. It's a better dosed Dermacrine, maybe more product (have to check Dermacrine bottle size), and two different ingredients than Res-V and 7,8 Benzo. I'm glad it's here, why all defensive?

Now as far as made up stories and drama - did you see the one where I didn't buy "production issues" as the reason for 2-Andro and 11-KT being discontinued? :D

Edit: Yup, I do like this. Dermacrine is 288mg/Day for 32.5 days. This would be 300mg/Day for 40 days. Same or lower price and it's a no-brainer. You get 12 more milligrams/Day and 7.5more days for someone who used 4 pumps of Dermacrine.
 
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