SubQ vs IM

cruze1911r1

cruze1911r1

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Just tried my first subq pin with test today. Really like it. So I'm curious, I've read about differences in hematocrit levels, free/total t and estradiol between the two administration methods given the same dose. Anyone done the experiments to see what changes take place?
 
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Daily sub q i dont notice any difference then daily im.

Ive seen lots of ppl go from 1-2×week to a daily sub q and they get a little more total t and less e2.

Its not going to lower hematocrit per say if its already high. But by doing daily sub q you may be able to keep hematocrit from rising as high.

So i just want to make that point, from my understanding and i do from time to time do my trt and even low dose cycles all sub q in the glutes. It may slow the rise of hematocrit, but if its high then its not going to "make it come down". It may help it come down faster but its definately not a gurentee. The biggest difference between daily im and daily sub q is really just what is your prefrence
 

Stacks1

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I haven't tried subq yet but I will say that some of the people who I know that switched to subq plan on never switching back.

People who are afraid of pinning should actually be encouraged to pin subq. Half the country is basically pinning insulin, semaglitude, or something else subq anyways as it is.
 
NegativeMass

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Works for some and not others. I tried sub q pharma trt grape seed oil. Went fine for a few weeks, then suddenly I started getting a severe allergic reaction. Huge welts, rash all over my body, and itching so bad I could hardly sleep. It took a couple weeks to go away. IM with GSO or MCT is no problem though. Rarely even get pip. Everyone's body is different.
 

bbsquatter

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Just tried my first subq pin with test today. Really like it. So I'm curious, I've read about differences in hematocrit levels, free/total t and estradiol between the two administration methods given the same dose. Anyone done the experiments to see what changes take place?
Behind a paywall. If you have a access to a university, you can download it from their campus or remote login

Choi, Edward J., et al. "Comparison of outcomes for hypogonadal men treated with intramuscular testosterone cypionate versus subcutaneous testosterone enanthate." The Journal of Urology 207.3 (2022): 677-683.

Results:
Post-TRT, both cohorts had significant increases in trough TT compared to their baseline levels (IM-TC: 313.6 ng/dL to 536.4 ng/dL, p <0.001; SCTE-AI: 246.6 ng/dL to 552.8 ng/dL, p <0.001). After linear regression, type of TRT modality was not found to be associated with TT levels (p=0.057). SCTE-AI was independently associated with lower post-therapy E2 (p <0.001) and HCT (p <0.001). Neither TRT modality was associated with significant post-therapy elevation of PSA (p=0.965).

Conclusions:
While IM-TC and SCTE-AI provide a significant increase in TT levels, SCTE-AI is associated with lower levels of post-therapy HCT and E2 compared to IM-TC after adjusting for significant covariates. SCTE-AI is an effective testosterone delivery system with a potentially preferable safety profile over IM-TC.
 
cruze1911r1

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Behind a paywall. If you have a access to a university, you can download it from their campus or remote login

Choi, Edward J., et al. "Comparison of outcomes for hypogonadal men treated with intramuscular testosterone cypionate versus subcutaneous testosterone enanthate." The Journal of Urology 207.3 (2022): 677-683.

Results:
Post-TRT, both cohorts had significant increases in trough TT compared to their baseline levels (IM-TC: 313.6 ng/dL to 536.4 ng/dL, p <0.001; SCTE-AI: 246.6 ng/dL to 552.8 ng/dL, p <0.001). After linear regression, type of TRT modality was not found to be associated with TT levels (p=0.057). SCTE-AI was independently associated with lower post-therapy E2 (p <0.001) and HCT (p <0.001). Neither TRT modality was associated with significant post-therapy elevation of PSA (p=0.965).

Conclusions:
While IM-TC and SCTE-AI provide a significant increase in TT levels, SCTE-AI is associated with lower levels of post-therapy HCT and E2 compared to IM-TC after adjusting for significant covariates. SCTE-AI is an effective testosterone delivery system with a potentially preferable safety profile over IM-TC.
Good stuff thank you
 

kisaj

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I went subq for awhile and it seemed better because I was "level" all the time and tried to remove the excess energy I have always got the next day, but labs showed that it wasn't working for me. Higher hemoglobin, total test in supra levels (average was 1000-1200), e2 stayed the same, and BP went up. This was doing 10mg daily (so only 70mg per week for non mensas lol). So while it felt like it was better, it wasn't heathier. Went back to 2x week IM and everything came back in order. I'll deal with the "spike" energy I get 24-36 hours after injecting.
 

bbsquatter

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I went subq for awhile and it seemed better because I was "level" all the time and tried to remove the excess energy I have always got the next day, but labs showed that it wasn't working for me. Higher hemoglobin, total test in supra levels (average was 1000-1200), e2 stayed the same, and BP went up. This was doing 10mg daily (so only 70mg per week for non mensas lol). So while it felt like it was better, it wasn't heathier. Went back to 2x week IM and everything came back in order. I'll deal with the "spike" energy I get 24-36 hours after injecting.
Back in late 1990s a physician wrote me an Rx of Serostim, recombinant DNA somatropin, that my health insurance covered. It was supposed to be administered SQ daily, hated it, altered it to every other day, still hated the SQ routine, and when Serostim gave me adverse events, bone and joint pain, I stopped taking it.

Years later an IVF physician told me as his patient that I needed to take HCG SQ every 3 days for 6 months minimum to increase my sperm count if we wanted to have children. Six months turned into 12. Used a 31G needle. Absolutely hated it. Never again.

I'll take IM once every 7-14 days gladly.
 

kisaj

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S
Back in late 1990s a physician wrote me an Rx of Serostim, recombinant DNA somatropin, that my health insurance covered. It was supposed to be administered SQ daily, hated it, altered it to every other day, still hated the SQ routine, and when Serostim gave me adverse events, bone and joint pain, I stopped taking it.

Years later an IVF physician told me as his patient that I needed to take HCG SQ every 3 days for 6 months minimum to increase my sperm count if we wanted to have children. Six months turned into 12. Used a 31G needle. Absolutely hated it. Never again.

I'll take IM once every 7-14 days gladly.
If you are referring to test cyp, injection every 7-14 days makes no sense.
 

kisaj

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The data is widely available to you if you’ve looked at anything in the last 7-8 years regarding protocols.
 

Stacks1

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I went subq for awhile and it seemed better because I was "level" all the time and tried to remove the excess energy I have always got the next day, but labs showed that it wasn't working for me. Higher hemoglobin, total test in supra levels (average was 1000-1200), e2 stayed the same, and BP went up. This was doing 10mg daily (so only 70mg per week for non mensas lol). So while it felt like it was better, it wasn't heathier. Went back to 2x week IM and everything came back in order. I'll deal with the "spike" energy I get 24-36 hours after injecting.
Did you ever try just doing subq 2 days a week instead of IM 2x per week? I get that people like subq because it's easier to pin and doing it every day is simple, however you can still easily pin your test 2x per week subq. I wonder if just pinning subq 2x per week would have raised your hemoglobin compared to IM 2x per week or if it was because you were pinning daily.
 

Jstrong20

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I went subq for awhile and it seemed better because I was "level" all the time and tried to remove the excess energy I have always got the next day, but labs showed that it wasn't working for me. Higher hemoglobin, total test in supra levels (average was 1000-1200), e2 stayed the same, and BP went up. This was doing 10mg daily (so only 70mg per week for non mensas lol). So while it felt like it was better, it wasn't heathier. Went back to 2x week IM and everything came back in order. I'll deal with the "spike" energy I get 24-36 hours after injecting.
what does your total test usually come back as? I'm guessing not 1200 so It sounds like it does work better. I wonder if maybe you lowers the dose more if everything would of came back in range. I'm not on trt or a dr so don't listen to me.lol. I just find it interesting on how much of a diffrence it can make.
 

Stacks1

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what does your total test usually come back as? I'm guessing not 1200 so It sounds like it does work better. I wonder if maybe you lowers the dose more if everything would of came back in range. I'm not on trt or a dr so don't listen to me.lol. I just find it interesting on how much of a diffrence it can make.
Yeah I do have to admit it's pretty impressive that he's able to get his test levels that high on only 70mgs of test per week. Typically that would be viewed as a huge win because you're getting higher test levels and using much less test to do so. I think my next cycle I might do all subq :unsure:
 

kisaj

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what does your total test usually come back as? I'm guessing not 1200 so It sounds like it does work better. I wonder if maybe you lowers the dose more if everything would of came back in range. I'm not on trt or a dr so don't listen to me.lol. I just find it interesting on how much of a diffrence it can make.
Total test is generally around 700-800 which is where feel really good. I didn't mention it but with it higher, I felt the same in general mood wise. The only difference was that I didn't have the energy I get the day after injection when I go IM. In some ways it is good because it's like a dopamine rush, but it can be a bit much. To answer your question, could I have continued to lower it- probably. But considering it was throwing other labs out of wack and I wasn't seeing benefit (I don't see supra levels of test as a benefit), I decided to forgo it. Specialist hypothesized that it was continual build up as it dissipates at a far slower rate subq, but we never chased it.

In any case, it may work well for some. I am just sticking with my 2x weekly IM. It's been many years on TRT and I am just always seeking an edge but I am over it.
 

sammpedd88

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Total test is generally around 700-800 which is where feel really good. I didn't mention it but with it higher, I felt the same in general mood wise. The only difference was that I didn't have the energy I get the day after injection when I go IM. In some ways it is good because it's like a dopamine rush, but it can be a bit much. To answer your question, could I have continued to lower it- probably. But considering it was throwing other labs out of wack and I wasn't seeing benefit (I don't see supra levels of test as a benefit), I decided to forgo it. Specialist hypothesized that it was continual build up as it dissipates at a far slower rate subq, but we never chased it.

In any case, it may work well for some. I am just sticking with my 2x weekly IM. It's been many years on TRT and I am just always seeking an edge but I am over it.
Glad to see you posting again @kisaj. I’m a lucky one. I’ve been on TRT for 10 years now. I’ve been on 100 mgs of test cyp split into 2 weekly doses. I was still having to use an AI to keep my E2 down. My total test was in the low 700’s but E2 was in the 60’s without an AI. I switched to subq with 3x week injections about 8 months ago. My total test is in the 600’s but my E2 is 29 and all my other levels are great. I know what you mean about searching for an edge. I’ve been the same way but I’ve come to the conclusion that I don’t think there is an edge anymore lol.
 

kisaj

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Glad to see you posting again @kisaj. I’m a lucky one. I’ve been on TRT for 10 years now. I’ve been on 100 mgs of test cyp split into 2 weekly doses. I was still having to use an AI to keep my E2 down. My total test was in the low 700’s but E2 was in the 60’s without an AI. I switched to subq with 3x week injections about 8 months ago. My total test is in the 600’s but my E2 is 29 and all my other levels are great. I know what you mean about searching for an edge. I’ve been the same way but I’ve come to the conclusion that I don’t think there is an edge anymore lol.
LOL!
 

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Given that I want to try this, how much can I inject subq? Online it said that up to 2 is safe subq but that seems extremely high to me and I don't want a golf ball sticking out of my stomach. I was thinking along the lines of 0.3 - 0.5 range.
 
SkRaw85

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Given that I want to try this, how much can I inject subq? Online it said that up to 2 is safe subq but that seems extremely high to me and I don't want a golf ball sticking out of my stomach. I was thinking along the lines of 0.3 - 0.5 range.
.5 ml is the upper limit of sub q to the gut for me. Plenty of other sites hold more though
 

Stacks1

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.5 ml is the upper limit of sub q to the gut for me. Plenty of other sites hold more though
Thanks. I was thinking .3 - .5 would be the rough range for stomach. Have you tried other areas? If you can get away with 1ml in the buttocks without issue that would pretty much make running an entire subq cycle quite easy.
 
SkRaw85

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Thanks. I was thinking .3 - .5 would be the rough range for stomach. Have you tried other areas? If you can get away with 1ml in the buttocks without issue that would pretty much make running an entire subq cycle quite easy.
Glutes and hip are my favorite sub q for up to 1 ml. I’ve never pinned quads (sub or IM) ever but hear it’s not so bad lol
 

Stacks1

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Glutes and hip are my favorite sub q for up to 1 ml. I’ve never pinned quads (sub or IM) ever but hear it’s not so bad lol
Nice! If I can get 1ml in the glutes or hip without lumps then that would certainly make the whole subq cycling much easier for me. Thanks!
 

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