Stop Crushing Anavar Under Your Tongue- It Won't Work

[dontfyourlife]

Everyone has their own personal opinion- just giving mine from a research perspective.

If you disagree cool- but before going back to the "Works great for me and I’ve done very extensive experiments with these types of things"

Follow the logic and if you have time check out the research papers- They tend not to be opinions

Basically....Taking oral Anavar tablets and placing them sublingually is not just pointless -it's pharmacologically counterproductive.

Issue 1- Anavar barely dissolves in saliva

Anavar is classified as practically insoluble in water. Sublingual drugs need to rapidly dissolve in the thin layer of saliva under your tongue as that's how it's designed to work.

Unfortunately Anavar tablets are compressed with hard binders like microcrystalline cellulose and magnesium stearate, engineered for GI tract breakdown- not for rapid dissolution in a less than of a milliliter of saliva that is in your mouth.

Sublingual tablet design requires drugs to have biphasic solubility. Which in plain English is high enough lipid solubility to cross the mucosa, but... also enough water solubility to dissolve in your limited amount of saliva first.

Smashing a tablet to chalk like consistency doesn't come close to the above.

Issue 2- Dosing becomes less effective

Sublingual delivery depends heavily on the drug not being swallowed in saliva before absorption is complete.

Drug makers designing "real" sublingual tablets have clear instructions on the packaging to avoid swallowing saliva during administration- because even that compromises absorption.

With a standard Anavar tablet that doesn't dissolve quickly you're inevitably swallowing chalky particles and drug loaded saliva the entire time. Ironically routing it right back through the GI tract. (except without the protective coatings needed to not get destroyed in the GI tract)

Congrats.....you just created a way less effective version of swallowing the pill in the first place.

Show me the Money- Or the science

Now this is copied/pasted from the research paper

For a drug to work sublingually, all of the following must be met:

• Sublingual epithelium thin enough for passive diffusion (100–200 μm)
• Slightly higher lipophilicity than required for GI absorption
• Unionized state at salivary pH (~6.0)
• Favorable oil-to-water partition coefficient (range: 40–2,000)
• Adequate water solubility to dissolve in saliva first
• Must not bind excessively to oral mucosa — binding traps the drug rather than allowing systemic absorption

Source: Innovare Academic Sciences, IJCPR 2017

In other words by doing the crush/dissolve method you are significantly reducing your effective dose by removing the very mechanism the tablet was designed for.

Or..... Just swallow the [explicit] pill

Sources: Innovare Academic Sciences (IJCPR, 2017) · Pharmaceutical Technology · INCHEM PIM 913 · PubMed 21764219

 

[Smont]

Sounds great on paper, but it does work, and it works just fine. It does change the pharmakinetics of the drug significantly, but those changes are part of the reason why people choose to do it sublingually pre-workout. Vigorous Steve has some incredibly good deep dives on similar topics and this topic specifically.

Taking it sublingually is not necessary, but it absolutely still works

 

[dontfyourlife]

Yes and no- Some compounding pharmacies actually make Anavar in subling lozenges so definitely available.

Unfortunately I wish the tablets crushed/dissolved did work as after worrying about lipids, it's the liver that I worry about next. (plus no cocktails for 8 weeks is annoying).

The reason it doesn't work how the drug is inherently constructed.
All sublinguals have to absolutely have these three things-

1) Drug needs to penetrate the epithelial tissue through passive diffusion. Tablets in powder form aren't designed for that.

2) Absolutely has to to have a favorable oil to water partition coefficient- Plain English the right chemical balance to cross the mucosal membrane

3) Enough water solubility to actually dissolve in saliva first, which the original medication has to be broken down and then binding the drug to sugar molecules that act as water soluble carriers or reducing the drug's particle size to increase its surface area. (technically a few more methods but one gets the point)


Love Vigerous Steve but the methodology is not interchangeable. Even the pharmacology on drugs that dissolve in the stomach vs small intestines vs colon all follow vastly different methods of manufacturing.

Personal opinion only though.

 

[Smont]

It's all good, I'm just going to have to agree to disagree on this one, and fat soluble drugs absorb amazingly sublingual. The lining of your mouth oral mucose is highly effective at absorbing lipophilic substances.


And I'm curious is anybody up for a little challenge?


25mg var per day - someone take theirs the way they'd like and I will do sublingual only.

I'm on trt SO the person who's doing this little experiment if anyone decides to should also be someone who's on trt and I will gladly adjust my trt to their dosage.

We both take before and after pictures and weekly updates

We both eat at maintenance calories

And the before and after pictures will let you know if it worked or not.

I mean I'm already 100% confident it works, but I'm kind of partially sidelined for a knee injury and my motivation is low and I need something to get my ass going and I think this would be a great little challenge if anyone's interested. At bare minimum you force yourself to go work out hard for 4 to 6 weeks.

Any takers?

 

[khall1974]

Would taking sublingual prevent the acid reflux I get?

 

[ironviking]

Alcohol can help break up those binders and fillers. High grade vodka works well.

I know some pill delivery systems are designed to get past the stomach acids but want aware anavar was in that category and still not sure it is. I'll look that up but if you have a pointer to where that is stated I'd appreciate if you could post it.