and don't take 4 caps all at once washed down with a mix of Purple Wrath and Poseidon...ouch. :dump:
hence the name, poopypants:dump:yea i cant do purple wrath and noxplode type supps they alone will send me to the john half way through a workout.
Glad everyone likes them- still need to do a little more tweakingim really loving the red and whites!
red n whites aren't giving me any explosive as* problems. could it be another supp youre taking?I really really like the blue and white version. Perhaps though you can tweak it to get rid of the side effect of green explosive poo!. Everything elese was great, but even at 3 caps I had the poops!. Still loving regular RPM though.
red n whites aren't giving me any explosive as* problems. could it be another supp youre taking?
RMS the amount of studies youve acrued on all the compounds you use are jsut retartedly amazing! its great to see you always have a studied response to everything and is an obvious indicator of why your products kick so much ass! keep up the good work my man!I think the place to start is the following studies- should be a fairly plausible explanation
Chin Med J (Engl). 2007 Feb 5;120(3):204-10.Click here to read Links
Icariine stimulates proliferation and differentiation of human osteoblasts by increasing production of bone morphogenetic protein 2.
Yin XX, Chen ZQ, Liu ZJ, Ma QJ, Dang GT.
Department of Orthopaedics, Peking University Third Hospital, Beijing, 100083, China.
BACKGROUND: Icariine is a flavonoid isolated from a traditional Chinese medicine Epimedium pubescens and is the main active compound of it. Recently, Epimedium pubescens was found to have a therapeutic effect on osteoporosis. But the mechanism is unclear. The aim of the study was to research the effect of Icariine on the proliferation and differentiation of human osteoblasts. METHODS: Human osteoblasts were obtained by inducing human marrow mesenchymal stem cells (hMSCs) directionally and were cultured in the presence of various concentrations of Icariine. 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) test was used to observe the effect of Icariine on cell proliferation. The activity of alkaline phosphatase (ALP) and the amount of calcified nodules were assayed to observe the effect on cell differentiation. The expression of bone morphogenetic protein 2 (BMP-2) mRNA was detected by reverse transcriptase-polymerase chain reaction (RT-PCR). RESULTS: Icariine (20 microg/ml) increased significantly the proliferation of human osteoblasts. And, Icariine (10 microg/ml and 20 microg/ml) increased the activity of ALP and the amount of calcified nodules of human osteoblasts significantly (P < 0.05). BMP-2 mRNA synthesis was elevated significantly in response to Icariine (20 microg/ml). CONCLUSIONS: Icariine has a direct stimulatory effect on the proliferation and differentiation of cultured human osteoblast cells in vitro, which may be mediated by increasing production of BMP-2 in osteoblasts.
Zhongguo Zhong Yao Za Zhi. 2005 Feb;30(4):289-91.Links
[Effects of Epimedium pubescens icariine on proliferation and differentiation of human osteoblasts]
[Article in Chinese]
Yin XX, Chen ZQ, Dang GT, Ma QJ, Liu ZJ.
Third Hospital of Peking University, Beijing 100083, China. [email protected]
OBJECTIVE: To study the effects of epimedium pubescens icariine on the proliferation and differentiation of human osteoblasts. METHOD: Human osteoblasts were obtained by inducting human marrow mesenchymal stem cells (hMSCs) directionally. MTT was used to observe the proliferation and activity of ALP was assayed to observe the differentiation of the third passage human osteoblasts cultured in vitro. The expression of BMP-2 mRNA was checked by RT-PCR. RESULT: Epimedium pubescens icariine at the dose of 20 microg x mL(-1) increased greatly the proliferation and differentiation of human osteoblasts and promoted the expression of BMP-2 mRNA. CONCLUSION: Epimedium pubescens icariine enhances significantly the proliferation and differentiation of human osteoblasts, which may be mediated by increasing the expression of BMP-2 mRNA.
J Bone Miner Res. 2007 Jul;22(7):1072-9.
Epimedium-derived phytoestrogen flavonoids exert beneficial effect on preventing bone loss in late postmenopausal women: a 24-month randomized, double-blind and placebo-controlled trial.
Zhang G, Qin L, Shi Y.
Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Hong Kong SAR, China.
Epimedium brevicornum maxim, a nonleguminous medicinal plant, has been found to be rich in phytoestrogen flavonoids. Results from a 24-month randomized double-blind placebo-controlled clinical trial showed that Epimedium-derived phytoestrogen flavonoids were able to exert beneficial effects on preventing bone loss in late postmenopausal women, without resulting in a detectable hyperplasia effect on the endometrium. INTRODUCTION: We performed a 24-mo randomized double-blind placebo-controlled clinical trial for evaluating the effect of the Epimedium-derived phytoestrogen flavonoids (EPFs) on BMD, bone turnover biochemical markers, serum estradiol, and endometrial thickness in postmenopausal women. MATERIALS AND METHODS: One hundred healthy late postmenopausal women, with a natural menopausal history within 10 approximately 18 yr and with a BMD T-score at the lumbar spine between -2 and -2.5 superdrol, were randomized into EPF treatment group (n = 50; a daily dose of 60 mg Icariin, 15 mg Daidzein, and 3 mg Genistein) or placebo control group (n = 50). All participants received 300 mg element calcium daily. BMD, bone turnover biochemical markers, serum estradiol, and endometrial thickness were measured at baseline and 12 and 24 mo after intervention. RESULTS: Eighty-five participants completed the trial. The patterns of BMD changes were significantly different between the EPF treatment group and placebo control group by repeated-measures ANOVA (p = 0.045 for interaction between time and group at femoral neck; p = 0.006 for interaction between time and group at lumbar spine). BMD was found with a decreased tendency in the placebo control group at 12 (femoral neck: -1.4%, p = 0.104; lumbar spine: -1.7%, p = 0.019) and 24 mo (femoral neck: -1.8%, p = 0.048; lumbar spine: -2.4%, p = 0.002), whereas EPF treatment maintained BMD at 12 (femoral neck: 1.1%, p = 0.285; lumbar spine:1.0%, p = 0.158) and 24 mo (femoral neck: 1.6%, p = 0.148; lumbar spine: 1.3%, p = 0.091). The difference in lumbar spine between the two groups was significant at both 12 (p = 0.044) and 24 mo (p = 0.006), whereas the difference in the femoral neck was marginal at 12 mo (p = 0.061) and significant at 24 mo (p = 0.008). Levels of bone biochemical markers did not change in the placebo control group. In contrast, EPF intervention significantly decreased levels of deoxypyrdinoline at 12 (-43%, p = 0.000) and 24 mo (-39%, p = 0.000), except for osteocalcin at 12 (5.6%, p = 0.530) and 24 mo (10.7%, p = 0.267). A significant difference in deoxypyrdinoline between the two groups was found at both 12 (p = 0.000) and 24 mo (p = 0.001). Furthermore, neither serum estradiol nor endometrial thickness was found to be changed in either groups during the clinical trial. CONCLUSIONS: EPFs exert a beneficial effect on preventing bone loss in late postmenopausal women without resulting in a detectable hyperplasia effect on the endometrium.
Icariin seems to elevate ALP significantly- along with many other drugs, including most types of anabolic steroids:
* Allopurinol
* Antibiotics
* Anti-inflammatory medicines
* Birth control pills
* Certain arthritis drugs
* Certain diabetes medicines
* Chlorpromazine
* Cortisone
* Male hormones
* Methyldopa
* Narcotic pain medicines
* Propranolol
* Tranquilizers
* Tricyclic antidepressants
So the heightened ALP, at least in this case, was caused by the icariin- from all the data I have gone over- this is simply a marker of increased metabolite retention, which is commonplace in a bone formation-type anabolic scenario, not any type of liver disorder- rest easy
No kidding, he always has the goods to back stuff up, its fantastic....i agree, great work man!!RMS the amount of studies youve acrued on all the compounds you use are jsut retartedly amazing! its great to see you always have a studied response to everything and is an obvious indicator of why your products kick so much ass! keep up the good work my man!
ALP in itself is not bad- it occurs in high levels during growth stages, during the healing of fractures, etc.- it is simply a by-product of increased nutrient retention due to an anabolic state (at least in this case).so if he remained on rpm, and/or the red n whites (supposing they include icariin as well) indefinitely, would the alp levels stay elevated? and when he comes off of the icariin supps, will the levels return to their normal state? and finally, at the heightened state alp is currently at, is this causing any damage itself?
and i thought we were going to have to call HOUSE on this one!! rms is da man!!ALP in itself is not bad- it occurs in high levels during growth stages, during the healing of fractures, etc.- it is simply a by-product of increased nutrient retention due to an anabolic state (at least in this case).
However, if your ALP levels are elevated, and you are not on any of the medications listed, have a fracture, etc. (no plausible explanation for high levels of ALP)- it could be a marker of liver damage....BUT having increased ALP will not cause damage in itself, and yes, ALP levels will return to normal upon cessation of the drug/supplement you are taking.:thumbsup:
Having an exoskelelton would have some SERIOUS advantagesMystery solved!
RMS is tha man.
So if I stay on RPM forever will I grow an exoskeleton?
lol
You could be like a human cockroach! :jaw:Having an exoskelelton would have some SERIOUS advantages
I was thinking more in terms of a human lobster....You could be like a human cockroach! :jaw:
Mmmm...250 pound lobster!!! :food:I was thinking more in terms of a human lobster....
Great review Bio!!LMAO!
Ok..on that note, this concludes my beta run and I'd like to thank RMS personally for allowing me the opportunity to test this product and humor my pestering of him.
This product, IMO, should be a great seller given that it works in such a short time. It's what all of us who demand instant gratification have been searching for in a supplement. It definitely falls into the category of "Supplements that I Never Want to be Without."...as I did a non-beta WO recently and I almost cried. lol
this is exactly what im scared about, ive got about 2 workouts left in mine....:aargh:as I did a non-beta WO recently and I almost cried. lol
It's coming-just got to work out a couple more kinksya i nursed the last of mine dry last week... was taking 2 pills aday with 6 RPM to try and get the same effect as 4 ed.... i cant wait till it comes out and i can try 6..... RMS PLEASE get this stuff out and make it even stronger though so i dont gots to take 6 caps..... id gladly pay 40-50bucks for a 120ct bottle that has each pill as strong as 2 red n whites.... :stick: thatd make a 40 day supply.... come on break outta the norm 1 month rule and please us with Stim free goodness....
i have never agreed more with someone else's comment. poop hit it right on the head... ummmm.....well, that sounded bizarre:think:ya i nursed the last of mine dry last week... was taking 2 pills aday with 6 RPM to try and get the same effect as 4 ed.... i cant wait till it comes out and i can try 6..... RMS PLEASE get this stuff out and make it even stronger though so i dont gots to take 6 caps..... id gladly pay 40-50bucks for a 120ct bottle that has each pill as strong as 2 red n whites.... :stick: thatd make a 40 day supply.... come on break outta the norm 1 month rule and please us with Stim free goodness....
i have never agreed more with someone else's comment. poop hit it right on the head... ummmm.....well, that sounded bizarre:think:
release them rms, for the good of the World(like the snickers commercial)!!:djparty:
YouTube - Broadcast Yourself.LMAO i love that commercial... me and the wifey bust out singing it everytime it comes on
i can hear it now!!Here's the AN version for RPM;
"50% ICariin mimics test-osterone
Enhanced by CYP450 binding effects
of Naringinen
Sending phytoandrogens coursing
throooogh your veins.
To limit the mild potential for estrogenic
Meh-tabo-lites
there's grapeseed extract
yeah, you heard that right
ANd the power of caffiene to make
your arms feel tight
your arrrrms feel tight."
:drunk:
:cheers: LMAO thats awesome.:head: id rock thatHere's the AN version for RPM;
"50% ICariin mimics test-osterone
Enhanced by CYP450 binding effects
of Naringinen
Sending phytoandrogens coursing
throooogh your veins.
To limit the mild potential for estrogenic
Meh-tabo-lites
there's grapeseed extract
yeah, you heard that right
ANd the power of caffiene to make
your arms feel tight
your arrrrms feel tight."
:drunk:
:goodpost:Here's the AN version for RPM;
"50% ICariin mimics test-osterone
Enhanced by CYP450 binding effects
of Naringinen
Sending phytoandrogens coursing
throooogh your veins.
To limit the mild potential for estrogenic
Meh-tabo-lites
there's grapeseed extract
yeah, you heard that right
ANd the power of caffiene to make
your arms feel tight
your arrrrms feel tight."
:drunk:
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