If one can spread the dosage out to 3dosages a day then that should be fine. If it is easier for one to take it all at once then that will be fine as well.
With or without food does not matter. Some oral anabolic steroids cause mild stomach issue but this varies among users. IF one is prone to this, then take with food.
Anavar is not a compound that causes rapid changes. The changes will be subtle overtime. The first differences will probably be strength increases. However, the better one's diet and training the better and quicker one will see results.