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Smart drugs.

I just have to say like everyone else-Focus XT

I had to give some BS death by PowerPoint presentation at work and I blew through it all quickly. I barely had to read it for my mind to spit it out of my mouth fluently.
 
I notice that I rarely see anyone mentioning phosphatidyl serine in most of the noot or smart drug threads. I had tremendous success years ago when I used to supplement with it. I also found that it helped greatly with anxiety. The only reason I stopped using it was because of the price, as it gets to be expensive running 200-300mg a day.

Anyone using this?
 
kisaj said:
Anyone using this?
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i have in the past. not much to report.
there seems to be inconclusive stance on the cognitive effects - altho for younger ppl it may help enhance mood.
PS has some benefits for exercise as well.

some intersting info on S-PS..

Memory and cognition

Early studies of phosphatidylserine distilled the chemical from bovine brain. Modern studies and commercially available products are made from soybeans, because of concerns about mad cow disease. The fatty acids attached to the serine in the soy product are not identical to those in the bovine product, which is also impure.

Preliminary studies in rats indicate that the soy product is at least as effective as that of bovine origin.[2][3]

Later clinical trials in humans found that "a daily supplement of S-PS (soybean derived PS) does not affect memory or other cognitive functions in older individuals with memory complaints."[4]

On May 13, 2003, the U.S. Food and Drug Administration stated "based on its evaluation of the totality of the publicly available scientific evidence, the agency concludes that there is not significant scientific agreement among qualified experts that a relationship exists between phosphatidylserine and reduced risk of dementia or cognitive dysfunction." FDA also stated "of the 10 intervention studies that formed the basis of FDA's evaluation, all were seriously flawed or limited in their reliability in one or more ways." It concludes that "most of the evidence does not support a relationship between phosphatidylserine and reduced risk of dementia or cognitive dysfunction, and that the evidence that does support such a relationship is very limited and preliminary."

FDA gave "qualified health claim" status to phosphatidylserine, stating that, "Consumption of phosphatidylserine may reduce the risk of dementia in the elderly" and "Consumption of phosphatidylserine may reduce the risk of cognitive dysfunction in the elderly."[5]

Sports nutrition

Phosphatidylserine has been demonstrated to speed up recovery, prevent muscle soreness, improve well-being, and might possess ergogenic properties in athletes involved in cycling, weight training and endurance running. Soy-PS, in a dose dependent manner (400 mg), has been reported to be an effective supplement for combating exercise-induced stress by blunting the exercise-induced increase in cortisol levels.[6] PS supplementation promotes a desirable hormonal balance for athletes and might attenuate the physiological deterioration that accompanies overtraining and/or overstretching.[7] In recent studies, PS has been shown to enhance mood in a cohort of young people during mental stress and to improve accuracy during tee-off by increasing the stress resistance of golfers.[8]
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kisaj said:
I notice that I rarely see anyone mentioning phosphatidyl serine in most of the noot or smart drug threads. I had tremendous success years ago when I used to supplement with it. I also found that it helped greatly with anxiety. The only reason I stopped using it was because of the price, as it gets to be expensive running 200-300mg a day.

Anyone using this?
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I've been using it on and off for almost nine months. I started it to attenuate high cortisol levels following a period of intense physiological stress and reset the HPTA axis. I used it consistently for two months and now use it spordically, usually after an intensive or tiring workout. I bought 100g of powder nine months ago a supplier in the UK.
 
saggy321 said:
I've been using it on and off for almost nine months. I started it to attenuate high cortisol levels following a period of intense physiological stress and reset the HPTA axis. I used it consistently for two months and now use it spordically, usually after an intensive or tiring workout. I bought 100g of powder nine months ago a supplier in the UK.
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Same here. I have found that I can benefit from longer periods of concentration or even relaxation when I take it in conjunction with my ADD medication.

Where did you find it in a powder?!?! It's so very expensive I rarely use it if im on a budget, but I have found some products with minimal amounts of the amine derivative and it still kinda does the trick.

Sent from my iPhone using Forum Runner
 
That is actually what I just ordered. It's a great deal when you get to pricing this out. I'm going to start this again and see how it goes and how it may work with Bacopa, AGPC, and Ani.
 
Anyone using noopept or dimiurge get moody on it?

I alternate between these 2 EOD never stacked together usually I take either or with Choline

but I find some days it makes me moody as hell

I am a 6 yr off and on fan of Focus XT and current cycle between caff free focus xt noopept and dimurge never back to back studying for promotion this yr
 
Outside Backer said:
Anyone using noopept or dimiurge get moody on it?
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That is a common side on noopept. For me, it made me feel really edgy and irritated because it felt speedy in my head. I guess some might be able to channel that into focus, but it just made me want to hit things.
 
Noopept made me rather intense. Sharp as a tack, but no fun to be around.

Demiurge, not as bad. Mostly good alertness.
 
Well, 4 days in on PS and the familiar feeling is back. Complete body calm when I take it in the morning. I usually wake up with some anxiety and my heart going a little faster but this sheds that in about 30min. I remember that I have to keep it at about 100-200mg a day because it makes me lazy if I take high doses.

I do think that there will be synergy with Ani because a calm body will help a calm mind and allow for clearer thinking.
 
kisaj said:
That is a common side on noopept. For me, it made me feel really edgy and irritated because it felt speedy in my head. I guess some might be able to channel that into focus, but it just made me want to hit things.
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Ok this is me too, if im alone and studying im lazer like, if idiots are around me i wanna chock the hell out of them lol
 
If you're wanting to dabble into nootropics I advise keeping it simple.
Aniracetam 750mg
alpha-gpc 300mg

3 times daily and youll wake up brains you never knew you had.
From experience, I have taken all racetams except pramiracetam, huperzine, alcar, dmaa, dmae, choline bitartrate, vinpocetine, sam-e, l-dopa, 5htp, GABA, picamilon, taurine, penibut, pqq, carnosine, every adaptogen there is, gout-kola, pea. Been prescribed adderall, klonopin, remeron, Wellbutrin, Ativan and buspar.
My point in all of this, this is my first post in years.... Things were so simple for me in my lifting days which have been long gone for a while. In 2010 I dabbled into so many nootropics that it lead to major depression which I'm still fighting. Keeping it simple, hitting the gym 5-6 times per week, taking anabolics and a healthy diet did more for me than any nootropic or drug could ever hold a candle to. The thing with nootropics is, being a genius with a memory like you've never had before isn't really a good thing, it takes a lot of fun out of life. The other issue is most nootropics favor enhancing Acetylcholine, the memory neurotransmitter. At first it's amazing as you wake up parts of your brain that have been sleeping your whole life. The problem becomes when the most important neurotransmitter in life, dopamine, starts dwindling as a result of boosting acetylcholine. They have sort of an antagonistic relationship with each other, dopamine goes up, acetylcholine goes down and vise versa. I've experienced first hand per-Parkinson's symptoms from experimenting with so many nootropics, and I'm only 27. The 2 that I mentioned are hands down the best I've used for all around use, motivation, memory, creativity...and gpc benefits bodybuilders by being a potent growth hormone releaser. Aniracetam is as close to egalitarian adderall as you'll find when it comes to focus and creativity, trust me I've been on Addy for 2 years, Aniracetam is a close second.
If you have any questions about nootropics or smart drugs feel free to pm me.
Freq~
 
freqfly said:
If you're wanting to dabble into nootropics I advise keeping it simple.
Aniracetam 750mg
alpha-gpc 300mg

3 times daily and youll wake up brains you never knew you had.
From experience, I have taken all racetams except pramiracetam, huperzine, alcar, dmaa, dmae, choline bitartrate, vinpocetine, sam-e, l-dopa, 5htp, GABA, picamilon, taurine, penibut, pqq, carnosine, every adaptogen there is, gout-kola, pea. Been prescribed adderall, klonopin, remeron, Wellbutrin, Ativan and buspar.
My point in all of this, this is my first post in years.... Things were so simple for me in my lifting days which have been long gone for a while. In 2010 I dabbled into so many nootropics that it lead to major depression which I'm still fighting. Keeping it simple, hitting the gym 5-6 times per week, taking anabolics and a healthy diet did more for me than any nootropic or drug could ever hold a candle to. The thing with nootropics is, being a genius with a memory like you've never had before isn't really a good thing, it takes a lot of fun out of life. The other issue is most nootropics favor enhancing Acetylcholine, the memory neurotransmitter. At first it's amazing as you wake up parts of your brain that have been sleeping your whole life. The problem becomes when the most important neurotransmitter in life, dopamine, starts dwindling as a result of boosting acetylcholine. They have sort of an antagonistic relationship with each other, dopamine goes up, acetylcholine goes down and vise versa. I've experienced first hand per-Parkinson's symptoms from experimenting with so many nootropics, and I'm only 27. The 2 that I mentioned are hands down the best I've used for all around use, motivation, memory, creativity...and gpc benefits bodybuilders by being a potent growth hormone releaser. Aniracetam is as close to egalitarian adderall as you'll find when it comes to focus and creativity, trust me I've been on Addy for 2 years, Aniracetam is a close second.
If you have any questions about nootropics or smart drugs feel free to pm me.
Freq~
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I completely second your thoughts and empathize with them. I came to the noot and supplement table from the other end..I battled chronic depression prior to supplements and fitness. I've tried nearly every supplement combo out there trying to perfect my state of mind and its function. Ani/GPC are among the best I have found. I agree that one should exercise caution with all noots as they can, and have, upend the apple cart. Neurotransmitter balance is a very fickle thing and basically trying to manipulate it is a hit or miss proposition.
 
I too agree with this. However, when you find the noot combo that works best for you, it is a cool feeling to walk into any room feeling like the brightest and most confident person in there.
 
There's that old saying "Knowledge is power".... I have to slightly disagree in stating "knowledge is POTENTIAL power". One can have all of the knowledge in the world but if it's not served for a meaningful purpose, it's as good as useless. Nootropics certainly increased my intelligence more than I ever thought possible and I've learned ore in the last 2 years than my first 25 alive; unfortunately having the intellect that certain nootropics can create causes life to be less enjoyable because before taking any action on anything, there are more analytical thoughts going through your mind and it blunts the original excitement when the action first made itself known. Hope this makes sense. Looking at it from a neurotransmitter point of view, dopamine is what creates the meaning to live, thrive, succeed and remain resilient as life throws you curve balls. Enhancing it through CERTAIN nootropics, nutritional approaches, and sometimes medication is the most important thing in th world for anyone IMO. there's no worse feeling in the world than waking up wishing you hadn't, that's low dopamine folks. When you get up, do 45 minutes of cardio followed by an hour in the gym hitting the iron in preparation for your upcoming competition, that's HIGH dopamine at its finest. Both Aniracetam and Alpha-GPC have pro-dopamanergic properties thus my reasoning for the recommendation. GPC enhances GABA release, growth hormone and facilitates an increase in dopamine release and an increased level of DOPAC, frankly reminds me of the mechanism of action of GHB without the euphoria. Aniracetam has actions on dopamine D2 receptors, serotonin 5ht2a receptors as well as nicotinic acetylcholine receptors. Anyone wanting to step into nootropics, open up their cognitive abilities, increase social abilities and improve their verbally reasoning, calculating and creative abilities, there's no better combo, IMO, that will do so safely without causing a long lasting depression as seen with others such as acetylcholieesterase inhibitors (huperzine).
 
freqfly said:
There's that old saying "Knowledge is power".... I have to slightly disagree in stating "knowledge is POTENTIAL power". One can have all of the knowledge in the world but if it's not served for a meaningful purpose, it's as good as useless. Nootropics certainly increased my intelligence more than I ever thought possible and I've learned ore in the last 2 years than my first 25 alive; unfortunately having the intellect that certain nootropics can create causes life to be less enjoyable because before taking any action on anything, there are more analytical thoughts going through your mind and it blunts the original excitement when the action first made itself known. Hope this makes sense. Looking at it from a neurotransmitter point of view, dopamine is what creates the meaning to live, thrive, succeed and remain resilient as life throws you curve balls. Enhancing it through CERTAIN nootropics, nutritional approaches, and sometimes medication is the most important thing in th world for anyone IMO. there's no worse feeling in the world than waking up wishing you hadn't, that's low dopamine folks. When you get up, do 45 minutes of cardio followed by an hour in the gym hitting the iron in preparation for your upcoming competition, that's HIGH dopamine at its finest. Both Aniracetam and Alpha-GPC have pro-dopamanergic properties thus my reasoning for the recommendation. GPC enhances GABA release, growth hormone and facilitates an increase in dopamine release and an increased level of DOPAC, frankly reminds me of the mechanism of action of GHB without the euphoria. Aniracetam has actions on dopamine D2 receptors, serotonin 5ht2a receptors as well as nicotinic acetylcholine receptors. Anyone wanting to step into nootropics, open up their cognitive abilities, increase social abilities and improve their verbally reasoning, calculating and creative abilities, there's no better combo, IMO, that will do so safely without causing a long lasting depression as seen with others such as acetylcholieesterase inhibitors (huperzine).
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Very interesting post as I have taken Alpha GPC for about 10 years now and added in Ani a little over a year ago. I am one of the biggest supporters of this combo. Also, to mention Huperzine in a negative view- as I do not play well with Huperzine. It causes me slight anxiety and a "race" feeling in my mind.
 
I like where you're going with that freqfly. I would venture to say that "Knowledge is only power if you know what to do with it." I've tried aniracetam and i have to say noopept blows it out of the water for me. never tried GPC so i will need to look into that. thanks for your post!
 
kisaj said:
Very interesting post as I have taken Alpha GPC for about 10 years now and added in Ani a little over a year ago. I am one of the biggest supporters of this combo. Also, to mention Huperzine in a negative view- as I do not play well with Huperzine. It causes me slight anxiety and a "race" feeling in my mind.
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It's easy once you're into nootropics and cognitive enhancers to slip into the "more is better" thought process. Looking back I wish I would've kept it simple with just Alpha-GPC and Aniracetam. I'll never forget the night I was in a realm of higher consciousness, uncomfortable as hell, afraid to move, all senses enhanced 1000x, all thanks to overdosing on too much Huperzine. I see so many people posting their ungodly regimens with 10-15 different substances with many of them doing the same things; just a matter of time before stacks like that turn against the user in every negative way imaginable. I'm glad GPC has done so well for you, 10 years is quite the relationship.
 
TruthWalker said:
I like where you're going with that freqfly. I would venture to say that "Knowledge is only power if you know what to do with it." I've tried aniracetam and i have to say noopept blows it out of the water for me. never tried GPC so i will need to look into that. thanks for your post!
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No worries. GPC has been the only choline source I've played well with. I find it's the most universal supp I've tried in terms of motivation, anxiliotic, cognitive function and physical benefits from growth hormone, liver enzyme repair and HPA axis support. I noticed the GH benefits from it when's co-worker commented on how much more filled out/bigger I looked one day after using GPC for a solid week; funny and sad part is it had been months since I stepped foot into the gym. I've heard pretty decent things about Noopept; my trouble is I suffer from PTSD and I find lately that anything that enhances memory too profoundly tends to spark some unpleasant things I'd prefer to forget. What are some effects you notice with Noopept in terms of motivation, optimism and overall positive thinking? Seems to be my biggest hurdle and Adderall is not cutting it anymore, besides the fact that my body is nothing compared to what it was per-Adderall and this year I'm wanting to get back into lifting/competing full force. Goal is to replace an antidepressant and Adderall through supplements/nootropics, Alpha-GPC will certainly be a player, Aniracetam was originally going to be the other half but if Noopept turns out to be superior I'll be switching to tht. Thx, freQ~
 
freqfly said:
What are some effects you notice with Noopept in terms of motivation, optimism and overall positive thinking? Seems to be my biggest hurdle and Adderall is not cutting it anymore, besides the fact that my body is nothing compared to what it was per-Adderall and this year I'm wanting to get back into lifting/competing full force. Goal is to replace an antidepressant and Adderall through supplements/nootropics, Alpha-GPC will certainly be a player, Aniracetam was originally going to be the other half but if Noopept turns out to be superior I'll be switching to tht. Thx, freQ~
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I have found a noticeable, acute increase in motivation, optimism, and overall positive thinking upon taking Noopept. I also believe there is a cumulative effect to the benefits of Noopept as the reading suggests, so it has just gets better and better. I take 10 or 20mg 3-4 times a day, and it really helps me increase my focus at work and my motivation to succeed in my job. Its really great, I take it first thing when I wake up in the morning and within 20-30 minutes my head is clear and I am alert. I would definitely give Noopept a try, I think you will really appreciate the effects compared to aniracetam.
 
I don't think it is an apples to apples comparison with Noopept and Aniracetam. Ani is much more social by creating a clear mind in allowing things to almost slow down and pull together to allow better comprehension and social interaction. You aren't searching for words or thoughts as they seem to always be at the tip of your mind, which makes it great for speaking engagements. It also shines the light on the anxiolytics properties.

Noopept is great for creating a clear, almost laser like focus, but is not that great (IMO) for social interaction and being around people. It's almost like the focus is too much and interruptions cause tension because your mind has to switch tasks, but it doesn't happen in a fluid motion. It feels like it has to stop, reset, and then focus on the new task. I found that if I had a big project to dive into, it was great because it was tunnel vision on what had to be done. Other than that, it wasn't enjoyable.
 
kisaj said:
I don't think it is an apples to apples comparison with Noopept and Aniracetam. Ani is much more social by creating a clear mind in allowing things to almost slow down and pull together to allow better comprehension and social interaction. You aren't searching for words or thoughts as they seem to always be at the tip of your mind, which makes it great for speaking engagements. It also shines the light on the anxiolytics properties.

Noopept is great for creating a clear, almost laser like focus, but is not that great (IMO) for social interaction and being around people. It's almost like the focus is too much and interruptions cause tension because your mind has to switch tasks, but it doesn't happen in a fluid motion. It feels like it has to stop, reset, and then focus on the new task. I found that if I had a big project to dive into, it was great because it was tunnel vision on what had to be done. Other than that, it wasn't enjoyable.
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I've read other people that have had the same reaction kisaj, but for me the social aspect of Noopept is very much apparent. I've found that Noopept greatly increases my verbal acuity, and this is a wonderful benefit for me as I am on the phone doing sales all day. I do agree with the laser like focus and tendency to get tunnel visioned though. Occasionally I will take 500-1000mg of Phenibut along with the noopept and I believe this combination really smooths out the Noopept experience for me and increases the fluidity of my thought processes. I've experimented with up to 40mg, but I like the 10-20mg range.
 
freqfly said:
If you're wanting to dabble into nootropics I advise keeping it simple.
Aniracetam 750mg
alpha-gpc 300mg

3 times daily and youll wake up brains you never knew you had.

Freq~
Click to expand...

take these with food or without? only nootropics ive tried are focus xt and pea. looking to try something else with focus xt this semester. Also start with maybe 500mg aniracetam and 200mg alpha-gpc? open to all suggestions love to learn.
 
drseuss6969 said:
take these with food or without? only nootropics ive tried are focus xt and pea. looking to try something else with focus xt this semester. Also start with maybe 500mg aniracetam and 200mg alpha-gpc? open to all suggestions love to learn.
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And will you succeed? Yes indeed, yes indeed! Ninety-eight and three-quarters percent guaranteed.


sorry, i had to break out a Seuss-ism for you.
 
drseuss6969 said:
take these with food or without? only nootropics ive tried are focus xt and pea. looking to try something else with focus xt this semester. Also start with maybe 500mg aniracetam and 200mg alpha-gpc? open to all suggestions love to learn.
Click to expand...
With a fat-containing meal homie. Aniracetam felt almost useless without food. Dosages are certainly there to play around with, that's what worked for me.
 
freqfly said:
The fat content plus DHA in fish oil blends increases the density of Dopamine D2 receptors which is one of the sites Aniracetam exerts its effects on.
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Do you think taking fish oil along with my noopept would also be beneficial? I mean obviously I can just try it and see, but I thought some other opinions would help :)
 
TruthWalker said:
Do you think taking fish oil along with my noopept would also be beneficial? I mean obviously I can just try it and see, but I thought some other opinions would help :)
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I personally haven't used it therefore I don't have a backed up opinion, but with my previous racetam experiences all performed better when taken with fish oil or olive oil.
 
Thanks for that info Freqfly. Anecdotally, I really felt a notable difference when taking it with 2-3 grams of fish oil on an empty stomach. It was a much more pronounced alertness which seems to mesh nicely with the info you provided.
 
bioman said:
Thanks for that info Freqfly. Anecdotally, I really felt a notable difference when taking it with 2-3 grams of fish oil on an empty stomach. It was a much more pronounced alertness which seems to mesh nicely with the info you provided.
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No worries. For even more focus throw in 500mg L-Tyrosine with 750mg Aniracetam and 250mg Alpha-GPC. Wash it down with a cup of black coffee and 500mg Thiamine; that blows Adderall away frankly.
 
THAT is exactly the stack I use when running Ani. Taking a break from it currently and noticing the difference.
 
freqfly said:
No worries. For even more focus throw in 500mg L-Tyrosine with 750mg Aniracetam and 250mg Alpha-GPC. Wash it down with a cup of black coffee and 500mg Thiamine; that blows Adderall away frankly.
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Is that Thiamine or Thianine?
 
SNS alcar 500 or focus xt
 
Anybody ever thought about suspending a fat soluble racetam (ani)? I was thinking about doing so with a few other fat soluble noots.
 
liquid said:
Anybody ever thought about suspending a fat soluble racetam (ani)? I was thinking about doing so with a few other fat soluble noots.
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Why make things harder than they need to be? Take a pill of Ani and wash it down with a glass of milk. Done.
 
That's what my 5 year old tries to tell me. haha

I drink enough for 4 humans, so I'll take your portion.
 
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