sir plus
- Thread starter keater824
- Start date
bpmartyr
Snuggle Club™ mascot
In our quest to conquer our goals, we rarely come across a supplement, much less a supplement company, that innovates powerful, natural ANABOLIC supplements with healthy benefits that are as potent as Pro-hormones and Designer-Anabolics.
As bodybuilders and athletes, we are interested in health benefits, but our main concern is performance. Whether it’s increasing your vertical leap or bench press numbers, we understand performance is the name of the game.
At USP Labs, we are aware that your main concern is recuperation from exercise to rapidly increase muscular development and speed performance. We’re also aware that you consistently push your body to the limits and rely on us to bring you cutting edge formulas that allow you to do so.
In that push to reach new heights, our immunity (and ultimately health) is sacrificed. And inflammation, the biggest killer known to man, runs rampant throughout your body.
The biggest evil’s halting your goals and progress are the previously mentioned inflammation (think injury) and lowered immunosuppresion (think sickness).
After much demand we’ve finally developed the ultimate health, anti-estrogen and anti-inflammatory formula: SirPlus.
SirPlus combines two of the most remarkable anti-oxidants ever created into one super supplement.
Resveratrol and Curcuminoids are sickness’s kryptonite. If you want superhuman immunity then you need SirPlus.
SirPlus is the superman of antioxidant and anti inflammation that even has the potential to extend lifespan.
SirPlus is a potent antioxidant and anti-inflammatory that can extend your performance life. In fact, it will even do much more than that (which is quite amazing in itself).
In research SirPlus has been shown to:
1. May prevent muscle protein breakdown (anti-catabolic effect in skeletal muscle tissue) (1-4)
2. Increase testosterone levels and sperm production by anti-estrogenic activities, acting as a SERM, though not necessarily in the classical sense (5-11).
3. Analgesic effects (12).
4. Protect against hearing loss (12).
5. Reduce injury to kidneys, liver, lungs, spinal cord, lungs, intestine, colon, brain and heart (12). It's as close as you can come to an all around, all tissue protector.
6. Potent antioxidant and anti-inflammatory effects, much greater than that of common antioxidants (12).
7. A synergistic effects for anticancer activity (13).
8. Potent effects upon cardiovascular health (12).
9. Prevent immunosuppression and liver damage seen with ethanol
consumption (12).
10. Potential to extend lifespan (12).
Hmm… Potential to extend lifespan, please explain!
SIRT1 (sirtuin 1) is an important protein in humans that is a key mediator in calorie restriction and longevity. It is in fact considered the primary target of Resveratrol's beneficial metabolic effects.
In fact, activation of SIRT1 is tied to lipolysis and potentially, energy expenditure. Increased activity of SIRT1 is generally found when following a calorie restricted diet. In turn, potential benefits such as anti-aging and neurological benefits are realized, amongst many others. What can one do to reap the benefits of increasing SIRT1 activity without having to actually decrease calorie intake? Simple, we use a calorie restriction mimetic, such as Resveratrol, which will mimic that benefit of increased SIRT1 activity, without having to sacrifice calories from those hungry muscles.
A recent study found a strong correlation between the variation in the SIRT1 gene and energy expenditure. In other words, we might infer that or at least suppose that increasing SIRT1 activity can result in improve metabolic activity, one feature of which would be increased energy expenditure and lipolysis. This has in fact been supported by recent studies in mice
There are a few Misunderstandings that we would like to address about Resveratrol.
1. Oral bioavailability isn't sufficient.
In Reality:
The extensive conjugation (sulfation and glucuronidation) doesn't mean that the compound has no oral bioavailability in humans. The question from those researching resveratrol has been how is resveratrol allowing for all of these beneficial effects despite having what they thought to be low oral bioavailability. One answer has been that perhaps, contrary
to the generalized rule of thumb that conjugation leads to inactivation, those conjugated resveratrol metabolites were still somewhat active in serum. The most recent answer with mounting evidence is that these conjugation products are acting as reservoirs or endogenous/biologic pro-drugs in the body, allowing for the release of free resveratrol locally and/or systemically after the conjugation moieties (sulfate and Beta-glucuronic acid) are cleaved by sulfatase and Beta-glucuronidase respectively (14-16). With this in mind, it explains why a much lower amount of resveratrol than calculated (i.e., if we assume conjugated products as permanently inactive metabolites) would need to be administered in order to achieve necessary serum concentrations of the free compound. A most recent study has in fact provided direct evidence to support this hypothesis (17).
The fact that many who are actually providing original research are taking regular trans-resveratrol provides some testament to the fact that oral bioavailability isn't the issue it was once thought to be.
2. Insufficient stability and degradation of product.
In Reality:
The stability of resveratrol has only been shown to be an issue when one is dealing with a reference standard of pure trans-resveratrol, not an extract
(18).
Sirplus Is A Must Have In Your Supplement Arsenal!
We did a very small first run of Sirplus. We only have 126 bottles of SirPlus in stock and they will be sold at a first come, first serve basis. Limit is 10 bottles per order.
Click here to order now!
References
1. Wyke SM, Tisdale MJ. “Induction of protein degradation in skeletal muscle by a phorbol ester involves upregulation of the ubiquitin-proteasome proteolytic pathway.� 2006 May;78(25):2898-2910
2. Thaloor D, et al. “Systemic administration of the NF-kappaB inhibitor curcumin stimulates muscle regeneration after traumatic injury.� Am J Physiol. 1999 Aug;277(2 Pt 1):C320-9
3. Tisdale MJ. “The ubiquitin-proteasome pathway as a therapeutic target for muscle wasting.� J Support Oncol. 2005 May-Jun;3(3):209-17.
4. Wyke SM, Russell ST, Tisdale MJ. “Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation.� Br J Cancer. 2004 Nov 1;91(9):1742-50.
5. Juan ME, et al. “trans-Resveratrol, a natural antioxidant from grapes, increases sperm output in healthy rats.� J Nutr. 2005 Apr;135(4):757-60.
6. Bowers JL, et al. “Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta.� Endocrinology. 2000 Oct;141(10):3657-67.
7. Wang Y, et al. “The Red Wine Polyphenol Resveratrol Displays BI-Level Inhibition on Aromatase in Breast Cancer Cells.� Toxicol Sci. 2006 Apr 11; E-Published Ahead of Print
8. Turner RT, et al. “Is resveratrol an estrogen agonist in growing rats?� Endocrinology. 1999 Jan;140(1):50-4.
9. Lu R, Serrero G. “Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells.� J Cell Physiol. 1999 Jun;179(3):297-304.
10. Bhat KP, Pezzuto JM. “Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma (Ishikawa) cells.� Cancer Res. 2001 Aug 15;61(16):6137-44.
11. Wu F, Safe S. "Differential activation of wild-type estrogen receptor
alpha and C-terminal deletion mutants by estrogens, antiestrogens and
xenoestrogens in breast cancer cells." J Steroid Biochem Mol Biol. 2007 Jan;103(1):1-9
12. Baur JA, Sinclair DA. “Therapeutic potential of resveratrol: the in
vivo evidence.� Nat Rev Drug Discov. 2006 Jun;5(6):493-506.
13. HemaIswarya S, Doble M. “Potential synergism of natural products in the treatment of cancer.� Phytother Res. 2006 Apr;20(4):239-49.
14. Walle T, Hsieh F, DeLegge MH, Oatis JE Jr, Walle UK 2004 High
absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 32: 1377-1382
15. Wang LX, Heredia A, Song H, Zhang Z, Yu B, Davis C, Redfield R 2004 Resveratrol glucuronides as the metabolites of resveratrol in humans: characterization, synthesis, and anti-HIV activity. J Pharm Sci 93:2448-2457.
16. Maier-Salamon A, Hagenauer B, Wirth M, Gabor F, Szekeres T, Jager W 2006 Increased Transport of Resveratrol Across Monolayers of the Human Intestinal Caco-2 Cells is Mediated by Inhibition and Saturation of Metabolites. Pharm Res 23:2107-2115
17. Abd El-Mohsen M, Bayele H, Kuhnle G, Gibson G, Debnam E, Kaila Srai S, Rice-Evans C, Spencer JP 2006 Distribution of [3H]trans-resveratrol in rat tissues following oral administration. Br J Nutr 96:62-70
18. Soleas GJ, Angelini M, Grass L, Diamandis EP, Goldberg DM 2001 Absorption of trans-resveratrol in rats. Methods Enzymol 335:145-154
As bodybuilders and athletes, we are interested in health benefits, but our main concern is performance. Whether it’s increasing your vertical leap or bench press numbers, we understand performance is the name of the game.
At USP Labs, we are aware that your main concern is recuperation from exercise to rapidly increase muscular development and speed performance. We’re also aware that you consistently push your body to the limits and rely on us to bring you cutting edge formulas that allow you to do so.
In that push to reach new heights, our immunity (and ultimately health) is sacrificed. And inflammation, the biggest killer known to man, runs rampant throughout your body.
The biggest evil’s halting your goals and progress are the previously mentioned inflammation (think injury) and lowered immunosuppresion (think sickness).
After much demand we’ve finally developed the ultimate health, anti-estrogen and anti-inflammatory formula: SirPlus.
SirPlus combines two of the most remarkable anti-oxidants ever created into one super supplement.
Resveratrol and Curcuminoids are sickness’s kryptonite. If you want superhuman immunity then you need SirPlus.
SirPlus is the superman of antioxidant and anti inflammation that even has the potential to extend lifespan.
SirPlus is a potent antioxidant and anti-inflammatory that can extend your performance life. In fact, it will even do much more than that (which is quite amazing in itself).
In research SirPlus has been shown to:
1. May prevent muscle protein breakdown (anti-catabolic effect in skeletal muscle tissue) (1-4)
2. Increase testosterone levels and sperm production by anti-estrogenic activities, acting as a SERM, though not necessarily in the classical sense (5-11).
3. Analgesic effects (12).
4. Protect against hearing loss (12).
5. Reduce injury to kidneys, liver, lungs, spinal cord, lungs, intestine, colon, brain and heart (12). It's as close as you can come to an all around, all tissue protector.
6. Potent antioxidant and anti-inflammatory effects, much greater than that of common antioxidants (12).
7. A synergistic effects for anticancer activity (13).
8. Potent effects upon cardiovascular health (12).
9. Prevent immunosuppression and liver damage seen with ethanol
consumption (12).
10. Potential to extend lifespan (12).
Hmm… Potential to extend lifespan, please explain!
SIRT1 (sirtuin 1) is an important protein in humans that is a key mediator in calorie restriction and longevity. It is in fact considered the primary target of Resveratrol's beneficial metabolic effects.
In fact, activation of SIRT1 is tied to lipolysis and potentially, energy expenditure. Increased activity of SIRT1 is generally found when following a calorie restricted diet. In turn, potential benefits such as anti-aging and neurological benefits are realized, amongst many others. What can one do to reap the benefits of increasing SIRT1 activity without having to actually decrease calorie intake? Simple, we use a calorie restriction mimetic, such as Resveratrol, which will mimic that benefit of increased SIRT1 activity, without having to sacrifice calories from those hungry muscles.
A recent study found a strong correlation between the variation in the SIRT1 gene and energy expenditure. In other words, we might infer that or at least suppose that increasing SIRT1 activity can result in improve metabolic activity, one feature of which would be increased energy expenditure and lipolysis. This has in fact been supported by recent studies in mice
There are a few Misunderstandings that we would like to address about Resveratrol.
1. Oral bioavailability isn't sufficient.
In Reality:
The extensive conjugation (sulfation and glucuronidation) doesn't mean that the compound has no oral bioavailability in humans. The question from those researching resveratrol has been how is resveratrol allowing for all of these beneficial effects despite having what they thought to be low oral bioavailability. One answer has been that perhaps, contrary
to the generalized rule of thumb that conjugation leads to inactivation, those conjugated resveratrol metabolites were still somewhat active in serum. The most recent answer with mounting evidence is that these conjugation products are acting as reservoirs or endogenous/biologic pro-drugs in the body, allowing for the release of free resveratrol locally and/or systemically after the conjugation moieties (sulfate and Beta-glucuronic acid) are cleaved by sulfatase and Beta-glucuronidase respectively (14-16). With this in mind, it explains why a much lower amount of resveratrol than calculated (i.e., if we assume conjugated products as permanently inactive metabolites) would need to be administered in order to achieve necessary serum concentrations of the free compound. A most recent study has in fact provided direct evidence to support this hypothesis (17).
The fact that many who are actually providing original research are taking regular trans-resveratrol provides some testament to the fact that oral bioavailability isn't the issue it was once thought to be.
2. Insufficient stability and degradation of product.
In Reality:
The stability of resveratrol has only been shown to be an issue when one is dealing with a reference standard of pure trans-resveratrol, not an extract
(18).
Sirplus Is A Must Have In Your Supplement Arsenal!
We did a very small first run of Sirplus. We only have 126 bottles of SirPlus in stock and they will be sold at a first come, first serve basis. Limit is 10 bottles per order.
Click here to order now!
References
1. Wyke SM, Tisdale MJ. “Induction of protein degradation in skeletal muscle by a phorbol ester involves upregulation of the ubiquitin-proteasome proteolytic pathway.� 2006 May;78(25):2898-2910
2. Thaloor D, et al. “Systemic administration of the NF-kappaB inhibitor curcumin stimulates muscle regeneration after traumatic injury.� Am J Physiol. 1999 Aug;277(2 Pt 1):C320-9
3. Tisdale MJ. “The ubiquitin-proteasome pathway as a therapeutic target for muscle wasting.� J Support Oncol. 2005 May-Jun;3(3):209-17.
4. Wyke SM, Russell ST, Tisdale MJ. “Induction of proteasome expression in skeletal muscle is attenuated by inhibitors of NF-kappaB activation.� Br J Cancer. 2004 Nov 1;91(9):1742-50.
5. Juan ME, et al. “trans-Resveratrol, a natural antioxidant from grapes, increases sperm output in healthy rats.� J Nutr. 2005 Apr;135(4):757-60.
6. Bowers JL, et al. “Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta.� Endocrinology. 2000 Oct;141(10):3657-67.
7. Wang Y, et al. “The Red Wine Polyphenol Resveratrol Displays BI-Level Inhibition on Aromatase in Breast Cancer Cells.� Toxicol Sci. 2006 Apr 11; E-Published Ahead of Print
8. Turner RT, et al. “Is resveratrol an estrogen agonist in growing rats?� Endocrinology. 1999 Jan;140(1):50-4.
9. Lu R, Serrero G. “Resveratrol, a natural product derived from grape, exhibits antiestrogenic activity and inhibits the growth of human breast cancer cells.� J Cell Physiol. 1999 Jun;179(3):297-304.
10. Bhat KP, Pezzuto JM. “Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma (Ishikawa) cells.� Cancer Res. 2001 Aug 15;61(16):6137-44.
11. Wu F, Safe S. "Differential activation of wild-type estrogen receptor
alpha and C-terminal deletion mutants by estrogens, antiestrogens and
xenoestrogens in breast cancer cells." J Steroid Biochem Mol Biol. 2007 Jan;103(1):1-9
12. Baur JA, Sinclair DA. “Therapeutic potential of resveratrol: the in
vivo evidence.� Nat Rev Drug Discov. 2006 Jun;5(6):493-506.
13. HemaIswarya S, Doble M. “Potential synergism of natural products in the treatment of cancer.� Phytother Res. 2006 Apr;20(4):239-49.
14. Walle T, Hsieh F, DeLegge MH, Oatis JE Jr, Walle UK 2004 High
absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos 32: 1377-1382
15. Wang LX, Heredia A, Song H, Zhang Z, Yu B, Davis C, Redfield R 2004 Resveratrol glucuronides as the metabolites of resveratrol in humans: characterization, synthesis, and anti-HIV activity. J Pharm Sci 93:2448-2457.
16. Maier-Salamon A, Hagenauer B, Wirth M, Gabor F, Szekeres T, Jager W 2006 Increased Transport of Resveratrol Across Monolayers of the Human Intestinal Caco-2 Cells is Mediated by Inhibition and Saturation of Metabolites. Pharm Res 23:2107-2115
17. Abd El-Mohsen M, Bayele H, Kuhnle G, Gibson G, Debnam E, Kaila Srai S, Rice-Evans C, Spencer JP 2006 Distribution of [3H]trans-resveratrol in rat tissues following oral administration. Br J Nutr 96:62-70
18. Soleas GJ, Angelini M, Grass L, Diamandis EP, Goldberg DM 2001 Absorption of trans-resveratrol in rats. Methods Enzymol 335:145-154