Simple GHRP-6 question

nosnmiveins

nosnmiveins

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does it need to be refrigerated after being reconstituted with BAC water?

if not, how long would it last at room temp?
 

Bigblondekid

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It won't last too long at room temp, it's best to keep it refrigerated, peptides don't have the strongest bonds and will break pretty easily. Don't shake it up either, that can break it down and make it worthless.
 

frozencore12

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In theory a small peptide like GHRP-6 should be stable without refrigeration, at least for a while. Peptide bonds are fairly strong but can be broken if the pH is way off or if it gets hot. Eventually peptide bonds will break in water but it takes a long time. Direct exposure to sunlight should be avoided.
 
nosnmiveins

nosnmiveins

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i found the answer on another board, i'll post it here

Posted by Datbrute

The following seems to indicate that GHRP-6 which is a simple peptide chain unlike IGF-1 which is more complex, is relatively resistant to degradation under the right circumstances at room temperature for almost five years.


The influence of the various buffer species (acetate, citrate, phosphate and borate) was shown to be different and the maximum stability of GHRP-6 was revealed to be in acetate buffer of pH 5.5-6.0. Degradation of GHRP-6 was greater in citrate-containing buffers than in acetate-containing ones. Furthermore, in the citrate-containing buffers, the higher buffer concentration caused greater degradation than the lower ones, but the concentration effect was negligible in acetate-containing buffers. Aqueous solution of GHRP-6 buffered with acetate (0.01 M, pH 5.5) showed a predicted t90% of 4.73 years at 20°C. - Degradation kinetics of growth hormone-releasing hexapeptide (GHRP-6) in aqueous solution, In Sik Ha… International Journal of Pharmaceutics Volume 144, Issue 1, 22 November 1996, Pages 91-97
 
jakellpet

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Datbrute is the walking encyclopedia of peptides man!
 
datBtrue

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Be careful with that post of mine. The stability in that study was achieved by using both a buffer and an acid and the meet in the middle so to speak. That means a very stable environment is created with very little depronation occurring.

We don't do that. Instead we use bacteriostatic water which gives us the proper pH but it isn't nearly as stable as the acid/buffer solution in the quoted study.

So when you reconstitute with BW you achieve the proper environment but increasing heat will speed degradation and increasing cold will reduce degradation. Putting it into the refrigerator will greatly decrease degradation. So refrigerate it!!!!!
 
nosnmiveins

nosnmiveins

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Be careful with that post of mine. The stability in that study was achieved by using both a buffer and an acid and the meet in the middle so to speak. That means a very stable environment is created with very little depronation occurring.

We don't do that. Instead we use bacteriostatic water which gives us the proper pH but it isn't nearly as stable as the acid/buffer solution in the quoted study.

So when you reconstitute with BW you achieve the proper environment but increasing heat will speed degradation and increasing cold will reduce degradation. Putting it into the refrigerator will greatly decrease degradation. So refrigerate it!!!!!
thanks DAT
 
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