bigbb123
i'm going to dose aromasin at 25mg a day and taper down
Aromasin is a steroidal "suicide" inhibitor
ATD is a nonsteroidal "competitive" ai
ATD is also steroidal suicide inhibitor.
anastrozole (adex) would be an example for a non-steroidal competitive inhibitor, such as is letrozole (letro).
yeah thanks for all the input guys. No clomid then. Ok, another question, in terms of the gyno reduction thing, what ai should i run along with the ralox, if any, topical atd, oral atd, or aromasin and at what dosage?
studies concerning gyno reduction with ralo seem to indicate pretty long duration of the treatments (3+months). why would you want to run an AI as long as that? why run it alongside the ralo at all, concerning the possible sides?
if you decide to do this, you'll probably best served with a pretty low dose of the AI.
that is, unless you want to base the treatment on the AI - but the only studies i have seen were on anastrozole (aka arimidex), 6 months. e.g:
Int J Impot Res. 2004 Feb;16(1):95-7
Treatment of testosterone-induced gynecomastia with the aromatase inhibitor, anastrozole.
Rhoden EL, Morgentaler A.
Division of Urology, Beth Israel Deaconess Medical Center, Men's Health Boston, Harvard Medical School, Massachusetts 02445, USA.
[email protected]
Horm Res. 2004;62(3):113-8. Epub 2004 Jul 20
Treatment of pubertal gynecomastia with the specific aromatase inhibitor anastrozole.
Riepe FG, Baus I, Wiest S, Krone N, Sippell WG, Partsch CJ.
Division of Pediatric Endocrinology, Department of Paediatrics, Christian-Albrechts-Universität Kiel, Kiel, Germany.
J Clin Endocrinol Metab. 2004 Sep;89(9):4428-33
Safety and efficacy of anastrozole for the treatment of pubertal gynecomastia: a randomized, double-blind, placebo-controlled trial.
Plourde PV, Reiter EO, Jou HC, Desrochers PE, Rubin SD, Bercu BB, Diamond FB Jr, Backeljauw PF.
AstraZeneca Pharmaceuticals LP, Chesapeake 2B-126, 1800 Concord Pike, P.O. Box 15437, Wilmington, Delaware 19850-5437, USA.
[email protected]
as for long-term test boosting, see also:
J Clin Endocrinol Metab. 2004 Mar;89(3):1174-80
Effects of aromatase inhibition in elderly men with low or borderline-low serum testosterone levels.
Leder BZ, Rohrer JL, Rubin SD, Gallo J, Longcope C.
Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
according to those studies (however, some of which on pubertal boys), the dosage/duration would be 1mg/day for 6 months.
i am unsure, but ralo (60mg/day 3-6 months) seems to have a better track record for adult males.
combining AI and SERM is IMHO pretty difficult thing to do: there may be drug-drug interactions which lead to unwanted sides. e.g. the AI formestane has been shown to drastically increase the half-life of the SERM tamoxifen. this area seems not very well studied (at least not for this application, there seem to be some studies about SERM/AI combos for cancer treatment, though..
do not take this as medical advice however.
Many of these serms originated as breast cancer treatment, and some AI's as well(tamox,clomid,arrimadex) I dont think it is smart to mess with this stuff long term. Does not seem smart to take cancer medicine long term with no cancer....just my opinion...
as with most pharmaceutical drugs, AIs and SERMs have one or more mechanisms of action. those mechanisms of action (binding to the estradiol-beta receptor or aromatase enzyme) may affect estradiol-receptive tumor cells. but they may also have other effects as well (which is what we look after in PCT).
but look at e.g. aspirin: this is a blood thinner, which has pain reduction as a side. thalidomide was once sold to help pregnant women sleep (we know what came out of this). it is now sold in the 3rd world as anti-lepra drug (IIRC). and the pictogram on the package is such (crossed through pregnant women) that many illiterate women there are lead to think it's a contraceptive... uhm. back on track. what i wanted to say is: the pharmaceutical industry sells specific drugs for specific markets/demands. that does not necessarily mean a drug is not useful or safe for other purposes as indicated by its mechanism of action.
we also have to keep in mind that many (tens of thousands) people have to take those drugs for up to 5 years, and that safety and science of those compounds is pretty well established, compared to what some people here ingest on a regular basis. one obviously still has to inform oneself about the possible effects and interactions of those drugs before taking them, as they are powefrul and dangerous if applied wrongly.
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