Toxicity and side effects aside, I think there is certainly a place for natural alternatives as well as pharmaceutical options. Side effects can occur with both choices, no doubt..
If somebody is REALLY struggling with an acute situation, Rx is the way to go. I won’t argue there at all! While benzos are extremely addictive and cause dependency issues, they do the trick for anxiety more effectively than anything else. Concurrently starting up an SSRI could also eventually be effective, if you are lucky enough to get the right one for you from the start. Wellbutrin can be effective too.
Honesty, I think the best choice for kick you in the ass acute anxiety/depression would be dexedrine spansules (hit serotonin, norepinephrine, and dopamine) as it works from the first dose. Add on Klonopin (due to its long half life) for a benzo to combat the anxiety factor. That would be my recipe for getting someone in the fetal position out of bed that has been paralyzed by overwhelming anxiety/depression.