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Research on Various Nootropics

Some more:

Lycium barbarum (Goji berry)

Significant differences between day 1 and day 15 were found in the GoChi group (N = 16) in increased ratings for energy level, athletic performance, quality of sleep, ease of awakening, ability to focus on activities, mental acuity, calmness, and feelings of health, contentment, and happiness. GoChi also significantly reduced fatigue and stress, and improved regularity of gastrointestinal function. In contrast, the placebo group (N = 18) showed only two significant changes (heartburn and happiness). No significant changes in musculoskeletal or cardiovascular complaints were observed in either group. All parametric data (body weight, etc.) were not significantly different between groups or between day 1 and day 15 for either group...

These results clearly indicate that daily consumption of GoChi for 14 days increases subjective feelings of general well-being, and improves neurologic/psychologic performance and gastrointestinal functions. The data strongly suggest that further research is indicated to confirm and extend knowledge of the potential effects of Lycium barbarum upon human health.
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We examined the effects of Lycium barbarum fruit (goji) intake on general well-being in a randomized, double-blind, placebo-controlled 30-day intervention trial. Plasma levels of cortisol, dehydroepiandrosterone (DHEA), glucose, urea nitrogen (BUN) and lactic acid followed by an exercise challenge were assessed at the pre- and post-intervention. Relative to the placebo group (n=19), tiredness and overall health were significantly improved in the Lycium barbarum group (n=20). Cortisol, DHEA and lactic acid levels were significantly increased by the exercise for the pre-intervention: However, at the post-intervention, Lycium barbarum intake significantly attenuated cortisol and DHEA levels. Lactic acid levels were comparable for both groups, and glucose and BUN levels were not altered. These results show that Lycium barbarum consumption attenuates the adrenal steroid response and reduces the feeling of tiredness.
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Theacrine

The 200 mg dose of TC caused significant improvements in energy (TC: +8.6% vs. PLA: -5.7%, P=0.049) and reductions in fatigue (TC: -6.7% vs. PLA: +5.8%, P=0.04). A trend for improved concentration was also noted (TC: +2.4% vs. PLA: -1.3%, P=0.07). No changes in systemic hemodynamics or side effect profiles were noted. The N=6 cohort study demonstrated moderate to large effect sizes (0.50 to 0.71) with the 200 mg dose of TC over a 7-day period of assessment for the following subjective measures: energy, fatigue, concentration, anxiety, motivation to exercise and libido.

These preliminary data support the benefits of acute TeaCrine™ supplementation on subjective “energy” levels and some indices of mental performance.
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Subbed for updates. This thread is a goldmine.
 
Choline Bitartrate

A group of twenty-eight [healthy young] individuals ingested two grams of choline bitartrate or a placebo in two separate sessions. Seventy minutes post ingestion, participants performed a visuomotor aiming task in which they had to rapidly hit the centers of targets. Results showed that participants hit targets more centrally after choline supplementation. Pupil size (a cognition-sensitive biomarker) also significantly decreased after choline intake and correlated positively with the hit distance to the targets and the number of target misses, and negatively with reaction times. These findings point to a choline-induced bias towards action precision in the trade-off between speed and accuracy. The changes in pupil size suggest that choline uptake alters cholinergic functions in the nervous system...

We found that choline bitartrate administration improves visomotor performance and decreases pupil size of healthy humans. This is the first scientific evidence for a rapid change in the nervous system and behavior after choline ingestion, pointing at choline’s wide-ranging effects on cognition...

A particularly interesting observation from the present study was that individuals that were more effective (i.e., produced fewer misses) benefitted more from choline supplementation than less effective individuals. While this outcome pattern seems counterintuitive as one would expect more room for improvement in the less efficient individuals, we have observed similar patterns in other cognitive-enhancement interventions (e.g.,53). One possible explanation for such patterns might be that, at least in the cases being tested so far, the pre-interventional performance did not only reflect the current skill level but also the individual degree of short-term plasticity of the skill.
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Twenty-two female athletes (15 taekwondo and 7 judo athletes) were selected from different weight categories and divided into two groups, according to weight. The players in the experimental group took choline tablets [1g choline twice daily; equivalent to 2.4g choline bitartrate twice daily] for one week before a competition. The results revealed significant differences between pre- and post-competition measurements of leptin, free plasma choline, urine choline and urine malondialdehyde levels; body mass was also reduced in the post-competition measurements. In conclusion, choline supplementation could rapidly reduce body mass without any side effects on biochemical levels or static strength.
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So earlier you mentioned that Choline Bitartrate can be an effective nootropic, but I've heard time and time again it goes CDP, A-GPC and then CB. Is this true?
 
carmaf said:
So earlier you mentioned that Choline Bitartrate can be an effective nootropic, but I've heard time and time again it goes CDP, A-GPC and then CB. Is this true?
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CDP and GPC may still be better than bitartrate, but it's good to know that bitartrate is still effective, considering that it's a good bit cheaper than CDP or GPC. This is the first study showing cognitive benefits in healthy, non-elderly humans I've seen. Similarly, I've only seen two studies showing cognitive benefits in similar populations with CDP-choline, and I've yet to see one with Alpha-GPC. I'm hesitant to say that something that works better for people with cognitive disorders/decline would inherently work better in healthy people without impaired cognition, and I am not aware of any studies comparing these choline sources in healthy subjects. I suppose the best way to see would be to try them yourself and see how they compare. Choline bitartrate is the cheapest of the three, so if you're on a budget, it's nice to know that it still works.
 
You are the Noots wiz but from my limited knowledge, that profile looks incredibly sexy. I like how it has caffeine + Theanine + Ornithine, as I've seen you recommend that combo extensively, and I've never seen it all together in a profile before, but I've been meaning to try that combination.
 
drseuss6969 said:
If you were to build a noot stack with about 5-7 ingredients, what would your recommendation be?

I have always wanted to see what you or cooper would do
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I've recently trimmed down my nootropic/adaptogen stack, getting rid of the unessentials. It's easy to just keep adding ingredients to a stack, since there are so many promising ingredients, but the cost starts to add up, and the returns start to diminish. My final stack for this semester (my last exams are tomorrow) is:

-ALCAR
-Choline (bitartrate or CDP-choline; either one)
-Ashwagandha (preferably KSM-66)
-Bacopa (standardized for bacosides)
-Rhodiola (standardized for salidroside)
-Caffeine
-Theanine
-Ornithine HCL
-Piracetam

If I had to pick 7, it'd be the first 7 in the above list.
 
muscleupcrohn said:
I've recently trimmed down my nootropic/adaptogen stack, getting rid of the unessentials. It's easy to just keep adding ingredients to a stack, since there are so many promising ingredients, but the cost starts to add up, and the returns start to diminish. My final stack for this semester (my last exams are tomorrow) is:

-ALCAR
-Choline (bitartrate or CDP-choline; either one)
-Ashwagandha (preferably KSM-66)
-Bacopa (standardized for bacosides)
-Rhodiola (standardized for salidroside)
-Caffeine
-Theanine
-Ornithine HCL
-Piracetam

If I had to pick 7, it'd be the first 7 in the above list.
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Thank you for the guideline. Some questions: how much does that stack cost you overall, price per serving and how long does the stack last before you need to re-up on raws?
 
carmaf said:
Thank you for the guideline. Some questions: how much does that stack cost you overall, price per serving and how long does the stack last before you need to re-up on raws?
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It all depends on how much you're willing to order, and if you're willing to measure out powders, or you'd rather order capsules. If you're going with powders, you'll need a milligram scale with a .01g or better precision. It's not expensive at all, but it can be a pain to measure out several ingredients every day, and the mixture doesn't exactly taste good without added flavoring, if that matters to you. Conversely, if you decided to go with all capsules, it's a bit more expensive, but you don't have to take the time to measure out everything. The amount of capsules needed can add up though, mostly because every ingredient has its own capsule(s), so there's a lot of wasted space as opposed to if it was a single product.

It's not an expensive stack though, especially for what you're getting, and still costs you less than an energy drink (something like a Monster, Red Bull ,5-Hour Energy, etc) whichever route you go.
 
muscleupcrohn said:
I've recently trimmed down my nootropic/adaptogen stack, getting rid of the unessentials. It's easy to just keep adding ingredients to a stack, since there are so many promising ingredients, but the cost starts to add up, and the returns start to diminish.
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Totally agree. I've really narrowed mine down as well based upon a lot of trial and error and what works best with me. Mine is:

Rhodiola
Ashwagandha (KSM-66)
Alpha GPC
Aniracetam
L-tyrosine
Noopept (recent addition that I am testing again and having very favorable results with)
 
kisaj said:
Totally agree. I've really narrowed mine down as well based upon a lot of trial and error and what works best with me. Mine is:

Rhodiola
Ashwagandha (KSM-66)
Alpha GPC
Aniracetam
L-tyrosine
Noopept (recent addition that I am testing again and having very favorable results with)
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I have some l-tyrosine that I still haven't really used enough to say how I like it.

Do you take Noopept and a racetam together? For whatever reason, I've always taken one or the other.

I've found that Aniracetam is nice when I have to write a paper or do something creative, but Piracetam seems to be better when I'm focusing on something more mathematical, and Noopept really helps me organize things for some reason.
 
I take Ani as needed, typically before a conference or other meeting as the improved speech fluidity and thought compartmentalization are extremely beneficial in those situations.
 
This is my favorite thread on AM now. Love watching the Noot gods discuss and trickle down information that I sponge up.
 
kisaj said:
I take Ani as needed, typically before a conference or other meeting as the improved speech fluidity and thought compartmentalization are extremely beneficial in those situations.
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That makes sense. The few times I've wanted to be more social/talkative I've taken, in addition to my usual stack, aniracetam and some kava.

How much ani do you take?
 
Generally 750mg about 45-60 min prior with a little fat. If it is an all day meeting event, I will do my normal split with an early morning dose and second around 1pm. Both 750mg
 
I'm not sold on it. I've read quite a bit about it and just don't see any reason I'd use it, to be honest.
 
Cool, that would be helpful. There isn't much anecdotal evidence out there and that is what I really care about when it comes to noots. Obviously the science and studies behind it are helpful to peak interest in learning more about a supplement, but it's become less important to me.
 
kisaj said:
Cool, that would be helpful. There isn't much anecdotal evidence out there and that is what I really care about when it comes to noots. Obviously the science and studies behind it are helpful to peak interest in learning more about a supplement, but it's become less important to me.
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I feel that with a lot of these nootropics, especially the newer racetams and similar things, the research can only say so much for now. As you said, it can peak interest, but I don't think there's many human studies on these supplements, much less studies on healthy individuals, so anecdotal evidence is really the only way we can gauge the effectiveness of these supplements; they're not like, say, bacopa where there's at least a handful of studies on healthy people.

I wanted to ask you, what's your opinion regarding the safety of regular/continuous/long-term use of these newer racetams and other synthetic nootropocs? Piracetam has some longer term human studies showing safety, but there's really not much at all on a lot of these newer racetams and nootropics, which concerns me a bit, considering they are intended to have effects on the brain and cognition. At least with the natural herbal nootropics, we have hundreds or even thousands of years of anecdotal safety evidence.
 
muscleupcrohn said:
I feel that with a lot of these nootropics, especially the newer racetams and similar things, the research can only say so much for now. As you said, it can peak interest, but I don't think there's many human studies on these supplements, much less studies on healthy individuals, so anecdotal evidence is really the only way we can gauge the effectiveness of these supplements; they're not like, say, bacopa where there's at least a handful of studies on healthy people.

I wanted to ask you, what's your opinion regarding the safety of regular/continuous/long-term use of these newer racetams and other synthetic nootropocs? Piracetam has some longer term human studies showing safety, but there's really not much at all on a lot of these newer racetams and nootropics, which concerns me a bit, considering they are intended to have effects on the brain and cognition. At least with the natural herbal nootropics, we have hundreds or even thousands of years of anecdotal safety evidence.
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In particular, flmodafinil has interested me, but I can't seem to find much research on it at all.

Edit: I meant to edit my post, not quote it. Oh well.
 
muscleupcrohn said:
I feel that with a lot of these nootropics, especially the newer racetams and similar things, the research can only say so much for now. As you said, it can peak interest, but I don't think there's many human studies on these supplements, much less studies on healthy individuals, so anecdotal evidence is really the only way we can gauge the effectiveness of these supplements; they're not like, say, bacopa where there's at least a handful of studies on healthy people.

I wanted to ask you, what's your opinion regarding the safety of regular/continuous/long-term use of these newer racetams and other synthetic nootropocs? Piracetam has some longer term human studies showing safety, but there's really not much at all on a lot of these newer racetams and nootropics, which concerns me a bit, considering they are intended to have effects on the brain and cognition. At least with the natural herbal nootropics, we have hundreds or even thousands of years of anecdotal safety evidence.
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Can you give me an example of the newer racetams and noots you are referring to? NM, just saw you posted again.

For something like flmodafinil and the like, I generally would wait on something like that. There isn't a whole lot of info on it as you mention and very little anecdotal evidence as well. I am all about brain hacking and live a little on the edge with that, but still have reservations even though I am fairly liberal with this subject.
 
kisaj said:
Can you give me an example of the newer racetams and noots you are referring to? NM, just saw you posted again.

For something like flmodafinil and the like, I generally would wait on something like that. There isn't a whole lot of info on it as you mention and very little anecdotal evidence as well. I am all about brain hacking and live a little on the edge with that, but still have reservations even though I am fairly liberal with this subject.
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Thanks. I guess that most racetams (piracetam, aniracetam, oxiracetam, phenylpiracetam for example) and Noopept have some relatively decent-length human studies showing some basic level of safety, but things like flmodafinil and PRL-8-53 don't have much research at all, and I'm a bit wary of using them regularly (even if it's only once or twice a week).

Interestingly, when researching aniracetam, I found a study showing that "Huannao Yicong" outperformed aniracetam in treating senile mild Cognitive impairment.

"Huannao Yicong" is apparently a combination of "Polygonum, ginseng, Shichangpu, berberine, fenugreek, Chuanxiong other components."
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muscleupcrohn said:
Thanks. I guess that most racetams (piracetam, aniracetam, oxiracetam, phenylpiracetam for example) and Noopept have some relatively decent-length human studies showing some basic level of safety, but things like flmodafinil and PRL-8-53 don't have much research at all, and I'm a bit wary of using them regularly (even if it's only once or twice a week).

Interestingly, when researching aniracetam, I found a study showing that "Huannao Yicong" outperformed aniracetam in treating senile mild Cognitive impairment.

"Huannao Yicong" is apparently a combination of "Polygonum, ginseng, Shichangpu, berberine, fenugreek, Chuanxiong other components."
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I don't think I've ever asked, but what are your thoughts on Noopept? I am thinking of adding it to FocusXT and seeing if it does anything.
 
carmaf said:
I don't think I've ever asked, but what are your thoughts on Noopept? I am thinking of adding it to FocusXT and seeing if it does anything.
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I like it. I can't say I prefer it to piracetam for studying or doing school work (physics, calculus, etc), but it does make me want to organize things for some reason, so I use it accordingly when I have to clean or something like that.

It does have some interesting human research, including a study showing that, in healthy young adults:
Noopept, affecting positively a psychological component of the functional state, can be used for rapid adaptation to both cold and hot climate. In the hot climate, noopept also enhanced the physical work capacity
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There's also a study that compared 20mg Noopept to 1.2g piracetam in the "Treatment of Patients with Mild Cognitive Disorders in Organic Brain Diseases of Vascular and Traumatic Origin," which found that:
The results of the present trial of Noopept and piracetam
supported previous data [25] on the characteristics of the
actions of Noopept, which form a combination of nootropic,
mild psychostimulatory, and anxiolytic effects. Noopept was
found to produce positive therapeutic influences on cognitive
deficit and neurosis-like symptomatology in patients with
emotional lability (asthenic) disorder of vascular origin and
post-concussional syndrome. There were no significant differences
in the extents of the nootropic effects of Noopept and
piracetam. It should only be noted that unlike the balanced
profile of the therapeutic activity of Noopept, the action of
piracetam included a predominance of psychostimulatory
effects, which are undesirable in the treatment of patients with
mild cognitive disorders. Noopept had an advantage over
piracetam in terms of therapeutic efficacy and safety.
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As compared with piracetam, the use of Noopept was
associated with a 1.8-fold lower level of undesirable effects,
a risk of developing undesirable effects in patients of 22% to
76%, and a probable link between undesirable effects and
use of the agent of 13–57%
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*bold added by me for emphasis and ease of reading quickly
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I don't think that this study is enough to say that Noopept is superior to piracetam in healthy people, since while psychostimulatory effects may not be ideal or desirable for patients with cognitive impairments, it may be different for healthy individuals who may even be looking for a psychostimulatory effect.

It's worth looking into IMO.
 
Excellent post, as always.
 
muscleupcrohn said:
Thanks. I guess that most racetams (piracetam, aniracetam, oxiracetam, phenylpiracetam for example) and Noopept have some relatively decent-length human studies showing some basic level of safety, but things like flmodafinil and PRL-8-53 don't have much research at all, and I'm a bit wary of using them regularly (even if it's only once or twice a week).

Interestingly, when researching aniracetam, I found a study showing that "Huannao Yicong" outperformed aniracetam in treating senile mild Cognitive impairment.

"Huannao Yicong" is apparently a combination of "Polygonum, ginseng, Shichangpu, berberine, fenugreek, Chuanxiong other components."
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I agree with you about being a bit wary with those.

I would put many things in front of Ani for cognitive repair or treatment. The most prevalent aspects of Aniracetam are: the anxiolytic effects, speech fluidity, recall, and compartmentalization. The first thing I noticed when starting it years ago was the ability to speak so easy in front of large audiences and how words just flowed and were always at the tip of my tongue. As this progressed, the anxiolytic effects became evident and I was seeking situations where I could speak. So, chicken/egg. Do the anxiolytic effects allow the brain to process faster and into deeper recesses of the brain or does that ability take the anxiety off of these events.

Very interesting racetam and by far my favorite.
 
kisaj said:
I agree with you about being a bit wary with those.

I would put many things in front of Ani for cognitive repair or treatment. The most prevalent aspects of Aniracetam are: the anxiolytic effects, speech fluidity, recall, and compartmentalization. The first thing I noticed when starting it years ago was the ability to speak so easy in front of large audiences and how words just flowed and were always at the tip of my tongue. As this progressed, the anxiolytic effects became evident and I was seeking situations where I could speak. So, chicken/egg. Do the anxiolytic effects allow the brain to process faster and into deeper recesses of the brain or does that ability take the anxiety off of these events.

Very interesting racetam and by far my favorite.
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Interesting. I have a work-related event (a bikini contest) with an after-party at a club for work on Friday, and I'm usually relatively quiet, or at least not very socially outgoing among strangers, so I think I'll take some before that. I never have a problem talking or holding conversations once I'm engaged in a discussion, especially if it's a subject I'm knowledge about or interested in, but I'm not always fast to be the one to initiate conversations. Perhaps this could help there.
 
I think it could be your ticket to be honest. I'd be interested to see how it goes.

My job requires me to always be in front of people and am sitting in front of C-level at least a few times a week, so it is imperative that I am always "on". Seeing as how we are kind of opposite, I wonder how the effects may differ- or not.
 
kisaj said:
I think it could be your ticket to be honest. I'd be interested to see how it goes.

My job requires me to always be in front of people and am sitting in front of C-level at least a few times a week, so it is imperative that I am always "on". Seeing as how we are kind of opposite, I wonder how the effects may differ- or not.
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I'll post about how it works after I try it. Does 750mg in the morning and another 750mg pre-club (separated by several hours) sound good?
 
muscleupcrohn said:
Interesting. I have a work-related event (a bikini contest) with an after-party at a club for work on Friday, and I'm usually relatively quiet, or at least not very socially outgoing among strangers, so I think I'll take some before that. I never have a problem talking or holding conversations once I'm engaged in a discussion, especially if it's a subject I'm knowledge about or interested in, but I'm not always fast to be the one to initiate conversations. Perhaps this could help there.
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I think some pics may be in order for you to help me in my ongoing education in the field of Nootropics.
 
kisaj have you tried nasal semax? Or semax in general?

I'm trying to dial in on what noots to use as far as fluidity, vernacular and recall go.

Only thing I'm taking now is nasal Noopept+ 200mcg hup-a.

I'm looking at making this nootropic stack bigger/better for reasons concerning my job.

Semax 200mcg nasal
Noopept 15-30mg nasal
Hup -a 200mcg in the morning
Bacopa- ???

What do you or muscleupcrohn think or suggest?
 
tyga tyga said:
kisaj have you tried nasal semax? Or semax in general?

I'm trying to dial in on what noots to use as far as fluidity, vernacular and recall go.

Only thing I'm taking now is nasal Noopept+ 200mcg hup-a.

I'm looking at making this nootropic stack bigger/better for reasons concerning my job.

Semax 200mcg nasal
Noopept 15-30mg nasal
Hup -a 200mcg in the morning
Bacopa- ???

What do you or muscleupcrohn think or suggest?
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I have no experience with nasal nootropics, but if you're concerned with recall, the following may be worth looking into:
-Bacopa (165mg bacosides; either 1 dose or split into 2 doses. A single, full dose may have acute nootropic effects)
-ACAR (2g/day; 1 dose or split into 2 doses)
-Piracetam (2.4g 1-2x per day) *aniracetam may be better for what you're looking for, I just don't have much experience with it and there isn't as much research on it as there is with piracetam

As you mentioned, Huperzine can be useful, and the dose you mentioned is good. Noopept is also good, but I'm only familiar with oral dosing. I'm not really familiar with semax.

I also like ashwagandha, mostly for reducing stress and anxiety, although there is a new study showing benefits in regards to memory and cognition. I'd dose 600mg/day of KSM-66 ashwagandha (either 300mg twice daily or 600mg once daily).
 
tyga tyga said:
kisaj have you tried nasal semax? Or semax in general?

I'm trying to dial in on what noots to use as far as fluidity, vernacular and recall go.

Only thing I'm taking now is nasal Noopept+ 200mcg hup-a.

I'm looking at making this nootropic stack bigger/better for reasons concerning my job.

Semax 200mcg nasal
Noopept 15-30mg nasal
Hup -a 200mcg in the morning
Bacopa- ???

What do you or muscleupcrohn think or suggest?
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You essentially described all the reasons to take Aniracetam. Those are exactly the benefits of supplemting with it. You want a choline source and take it with fat.

My ideal stack for those purposes would be:
Aniracetam
Alpha GPC (or your choice )
Rhodiola
Ashwagandha

Noopept is a good addition for the anxiolytic qualities to piggy back Ani, and the overall clarity it provides. I almost view noopept as a base because it opens up your mind for consumption of info. So you take things in with better understanding and then are able to respond in like.
 
muscleupcrohn said:
I have no experience with nasal nootropics, but if you're concerned with recall, the following may be worth looking into:
-Bacopa (165mg bacosides; either 1 dose or split into 2 doses. A single, full dose may have acute nootropic effects)
-ACAR (2g/day; 1 dose or split into 2 doses)
-Piracetam (2.4g 1-2x per day) *aniracetam may be better for what you're looking for, I just don't have much experience with it and there isn't as much research on it as there is with piracetam

As you mentioned, Huperzine can be useful, and the dose you mentioned is good. Noopept is also good, but I'm only familiar with oral dosing. I'm not really familiar with semax.

I also like ashwagandha, mostly for reducing stress and anxiety, although there is a new study showing benefits in regards to memory and cognition. I'd dose 600mg/day of KSM-66 ashwagandha (either 300mg twice daily or 600mg once daily).
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PM coming your way.

kisaj said:
You essentially described all the reasons to take Aniracetam. Those are exactly the benefits of supplemting with it. You want a choline source and take it with fat.

My ideal stack for those purposes would be:
Aniracetam
Alpha GPC (or your choice )
Rhodiola
Ashwagandha

Noopept is a good addition for the anxiolytic qualities to piggy back Ani, and the overall clarity it provides. I almost view noopept as a base because it opens up your mind for consumption of info. So you take things in with better understanding and then are able to respond in like.
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I know Rhodiola and ksm-66 can be taken everyday for as long as you want right? What's the length you can take GPC and aniracetam? Do they have acute and cumulative benefits?
 
tyga tyga said:
PM coming your way.



I know Rhodiola and ksm-66 can be taken everyday for as long as you want right? What's the length you can take GPC and aniracetam? Do they have acute and cumulative benefits?
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I'm not kisaj, but I always thought choline sources could be taken indefinitely (as it's in Ergonine, for example). GPC is a choline source. It also has acute benefits 1 hour pre-workout of increasing strength (I guess due to better motor activation/focus)

Rhodiola/KSM-66 should be taken everyday for adaptogenic benefits, but for how long, some run them indefinitely and some stick to the 8-12 weeks/4 weeks off protocol.
 
-huperzine 200mcg AM
-Bacopa 165mg (bacosides)AM
-ksm-66 300mg AM
-L-theanine 200mg AM
-Aniracetame -??
-Noopept -15-30mg nasally AM
 
tyga tyga said:
-huperzine 200mcg AM
-Bacopa 165mg (bacosides)AM
-ksm-66 300mg AM
-L-theanine 200mg AM
-Aniracetame -??
-Noopept -15-30mg nasally AM
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Depending on your preference for stimulants, you may want to add some caffeine to that AM combination; I feel it goes very well with theanine and ashwagandha, and also gives you some energy in the morning, of course.

I think I remember kisaj saying he uses 750mg aniracetam in the AM and, if needed, another 750mg later in the day.

Choline can be taken indefinitely; the Tolerable Upper Intake Level for choline for adults is 3.5g/day choline.
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Ashwagandha can be run for a long time, but I'd still cycle off it at least once or twice a year for a few weeks. I'd stick to no more than 12 weeks on followed by a few weeks off for rhodiola.

As for aniracetam, kisaj can probably tell you more, but I've seen a study dosing aniracetam daily for 16 weeks (600mg/day; split into 3 200mg servings) to treat mild cognitive impairment in senile patients. I don't know if I'd want to use it for that long, but it's still good to see a longer-duration study.
 
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