at the end of the day it will not make much difference in the net result. As long as blood levels are kept stable (based on e/c versus sust optimal dosing) you will have little as possible sides. In my experience the more unstable blood levels are; the more sides like acne, mood etc. Otherwise it is purely personal preference. Some people swear by one or the other. Personally, in the past i would gravitate towards sust because i liked to "feel" it. After sust i would feel the agression in the gym increase the next couple days, mood would get better...but a decent drop of after 3 days or more post inj. i found eod was best for me. Enan or cyp twice a week should be plenty