Recovery of spermatogenesis following testosterone replacement therapy or anabolic-androgenic steroid use

[SouthPawSD]

Found this article and thought it would be an interesting read to some of the folks here. I'm guessing someone somewhere has referenced it at some point on here, but good to have it in its own topic to discuss.

Recovery of spermatogenesis following testosterone replacement therapy or anabolic-androgenic steroid use

The use of testosterone replacement therapy (TRT) for hypogonadism continues to rise, particularly in younger men who may wish to remain fertile. Concurrently, awareness of a more pervasive use of anabolic-androgenic steroids (AAS) within the general ...

www.ncbi.nlm.nih.gov

Thoughts on the article? Curious to see all of your thoughts.

 

[UNX]

Related:

Participants either received two implant pellets each containing 135mg of MENT acetate calculated to release 400mcg daily, or three 600mg testosterone pellets, with one given every 12 weeks. Both groups received 68mg of etonogestrel. Both groups experienced significant reduction in sperm production, with 80% of both groups going from an average of 55 x 106 mL to just 1 x 106 mL after 12 weeks of supplementation.8

Recovery from MENT was much more rapid than from testosterone. The recovery period was 16 weeks for the MENT group, in which semen concentration increased to over 20 x 106 mL—whereas the testosterone group still had azoospermia until after 28 weeks.8

Source: https://www.reddit.com/r/steroids/wiki/trestolone

 

[rtmilburn]

Related:



Source: https://www.reddit.com/r/steroids/wiki/trestolone

This is interesting. I wonder if the doses is what led to these results, as I cannot imagine trest not shutting you down way harder than testosterone. If that truly is the case no matter the dosage, then this is HUGE news!!!

 

[Jinsun]

Interesting. Ment is supposed to be super suppressive ...

 

[Nac]

400mcg daily? Thats less than 0.5mg per day.

We dose 100x that.

 

[Whisky]

Ment was originally developed as a male contraceptive if memory serves me correctly.....

on the original article the hcg dose at 500iu eod to maintain fertility was interesting - that’s higher than we typically use to keep the boy in the barracks but my assumption was always that was a fertility basis as well.....

 

[Jinsun]

Ment was originally developed as a male contraceptive if memory serves me correctly.....

on the original article the hcg dose at 500iu eod to maintain fertility was interesting - that’s higher than we typically use to keep the boy in the barracks but my assumption was always that was a fertility basis as well.....

Yeah, 250 to 500 yields very similar results. They referenced the same study that we usually do however.

What's more interesting is the slow but steady rise to the market of enclomiphene.