I think this really depends on how you use supplements and what you're expecting from them. The industry has skewed things to make users believe they cannot achieve success in health and fitness without the use of supplements. I feel like many people give supplements more credit than they deserve, but that doesn't mean I would advise "quitting" supplementation, especially of staple supplements like creatine, vitamin d, and fish oil.
The majority of supplements on the market are bogus, and the studies that back them aren't always consistent. However, I do think that there are some core supplements that can provide true benefits for overall health and performance. With supplement users becoming more educated with access to write-ups and studies on products, some companies are doing very well by stepping up their game to bring supplements to the market that actually work.
I think its good to cycle products and try different things to find what works for you and what doesn't, but I truly feel that there are some supplements that are studied and proven to be beneficial. Nutrition will always be number 1, but I don't think stopping all supplementation would be of any additional benefit to someone who lifts heavy and eats properly.