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proposed stack aka "the big nasty"

evan

evan

Member
I may run this a few months from now this has all the colors of the rainbow

3ed stimerex-es
3ed ap
3ed epistane
5-6 ed oxyguno

need to give my body sometime off thouhgh
 
I'm not sure how will the AP will work with the epistane. Pretty sure there is a thread around somewhere stating it works much better when estrogen is not inhibited, something epi does I'm pretty sure. Plus is it really needed with epi and humago?:clean: :bb:
 
I doubt the epi will negate the ap that much
and to answer question two, this is the same thin as asking why
people run both insulin and anabolics. they work throuh differnt pathways

think of it like this
your body is a bucket full of water with small holes in it, that are constantly leakin water
each hole represents a differnt pathway(pituatary/gonadal/thyroid) each path way(hole) you patch up prevents a possible loss of gains

the big pros basically take a different drug to replace each natural pathway. if you saw what they probably take youd get sick just lookin at the list
 
Question two wasn't really a question, more rhetorical as you would get amazing results without it. I still feel that since Glut-4 is sensitive to estrogen you would get better results with something like an insulin sensitizer or just getting real 'slin since you will be in an extremely anabolic state already. I understand how much the pro's take and why. I was not trying to say it won't work, but why not save it till your done and estrogen is normal? Get results with your hormonals and then when they are done get on the AP to help maintain gains. Also rations money better. To each their own though.
 
There should be relatively few holes in your bucket while on. Much more during PCT. If AP is the patch why not save it for when it will work 100% and cover more holes? To use your own metaphor.
 
the body is very complex no one supp or drug can do everythin. neative feed back loops make sure of this. slihtly-moderatly raisin a large variety of hormones should theoretically provide far longer lastin results then meadosin a few as the body will not try to snap back so quickly
 
look at author l rea's earlier articles he talks alot about this and he has a very good mixture of knowlede and real world testin on athletes
 
I've never heard ALR mention AP though. I agree that muscle insulin sensitivity would be a good thing being as you will be in the anabolic state. But why use the AP when it will be less effective. The AP does not mess with insulin, it messes with glut-4 and will not be 100% effective with lowered estrogen. Thats why I recommended taking the insulin sensitizer/mimicker or maybe real 'slin and saving the AP for PCT when it would be more effective. Never said not to try and modulate your bloodsugar/glycogen stores. Just to try and do it more effectively. Epistane does have AI action.
 
Epistane is NOT an AI. It is a SERM and will not hinder AP in any way. AP is an exceptional with anabolics and there is no reason it can't be used in PCT as well.

AI's will hinder glut-4, true. That would make AP a great supplement to take while using one to counter the effects by greatly increasing glut-4 action.
 
:ntome: Whoops, makes me feel stupid. I think something about that anabolic gyno destroyer thread had me convinced it had AI action. Took one search to prove that wrong. Sorry. Would this however be accurate?

Originally Posted by Ziricote
These results reveal that ER1 is a positive regulator of GLUT4 expression, whereas ER2 has a suppressive role
Click to expand...

Originally Posted by Dr.D
Epi is a steroidal SERM that binds selectively to E2-beta receptors.
Click to expand...

If so I still think it would be better to let Epi do its thing and use AP later, but I see your point in if Glut-4 was downregulated AP would help. I would just want the most bang for my buck personally, using it to 100% of its capabilities.
Now the real question. I know you guys said that the Phellodendron extract is not working to increase Glut-4 by the traditional AMPk route. Did you, however, ever release how it increases glut-4? Possibly ER1 binding???
 
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