PPAR-alpha help

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Ghosting

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Ive always associated Sesathin with fat loss. Recently I have wanted to understand it, so I read the write up. It seems to be centered around being a PPAR-alpha agonist. So I researched PPAR-alpha. It seems that PPAR-alpha is the target receptor for a fatty acid-based hormone called OEA. So could I just say (simplified of course), PPAR-alpha stimulates the mitochondria to burn fat?
 
Activating the PPAR-a (a la Sesathin) promotes peroxisome proliferation (the peroxisomes population increases) and increases signalling of fat burning enzymes used by the mitochondria and peroxisomes (the latter doesn't require as many as the former).
 
Robboe said:
Activating the PPAR-a (a la Sesathin) promotes peroxisome proliferation (the peroxisomes population increases) and increases signalling of fat burning enzymes used by the mitochondria and peroxisomes (the latter doesn't require as many as the former).
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So you are saying not only does it increase fat burning enzymes used by the mitochondria, but peroxisome enzymes (to a lesser degree) as well? Just want to make sure I understand what you are saying. :)
 
When PPARalpha is activated it causes the production of a group of proteins, many of which are directly involved in FFA oxidation. Activating PPARalpha with Sesathin or fish oil increases the transcriptions of fat burning enzymes, like CPT1, FAT/CD, UCP3, etc.--so you get this increase throughout the entirety of the tissue responsible for oxidation (either muscle or hepatic [live]).

Your body can oxidize FFAs in both the mitochondria and the peroxisomes, although they have somewhat different enzyme requirements for oxidation, and only the peroxisomes can oxidize VLCFA (very long chain fatty acids).
 
Loki said:
When PPARalpha is activated it causes the production of a group of proteins, many of which are directly involved in FFA oxidation. Activating PPARalpha with Sesathin or fish oil increases the transcriptions of fat burning enzymes, like CPT1, FAT/CD, UCP3, etc.--so you get this increase throughout the entirety of the tissue responsible for oxidation (either muscle or hepatic [live]).

Your body can oxidize FFAs in both the mitochondria and the peroxisomes, although they have somewhat different enzyme requirements for oxidation, and only the peroxisomes can oxidize VLCFA (very long chain fatty acids).
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The 2nd paragraph I can understand. :) The 1st paragraph is way beyond my level of comprehension and made my brain blow up at which time I wet my pants. I got my answer from the 2nd paragraph. Thanks.
 
Robboe said:
Loki wets his pants all the time.
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I kind of figured that about the Lokinator, after we hung last weekend and he had a strong odor of urine coming from him. :eek: :)
 
Ghosting said:
I kind of figured that about the Lokinator, after we hung last weekend and he had a strong odor of urine coming from him. :eek: :)
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Yeah, tell your mother she needs to change her sheets something desperate.
 
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