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Murad Releases Paper, 'Pomegranate's Internal and External Role in the War Against Environmental Aging and Disease,' by Howard Murad, M.D.
PR Newswire
06-06-06
LOS ANGELES, June 5, 2006 /PRNewswire via COMTEX/ -- The following paper was issued today by Murad, Inc.:
Pomegranate's Internal and External Role in
the War Against Environmental Aging and Disease
by Howard Murad, M.D.
Introduction
Each and every day, the skin -- our body's largest organ -- is bombarded with environmental assailants. In addition to external aggressors such as pollution, smoke, and ultraviolet radiation from the sun, the body's own metabolism causes cells to sustain one thousand hits of free radials daily, triggering the release of inflammatory mediators which break down collagen and damage cell barriers. In fact, internal damage caused by free radicals not only leads to the esthetic concern of wrinkled skin and hyperpigmentation, studies have shown this to be one of the main factors contributing to the formation of cancerous cells.
Since my early days as a dermatologist, I have been studying the ability of various antioxidants, such Vitamin C, Coenzyme Q 10, Alpha Lipoic Acid, and Vitamin E and herb extracts such as Burdock Root, Echinacea, Yellow Dock Root, and Grape Seed Extract to repair and protect the skin against such damage. While all are extremely beneficial, I found the most potent antioxidant power to date comes from Pomegranate Extract, and specifically the polyphenol, Ellagic Acid contained within the pomegranate.
In this paper, I would like to demonstrate pomegranate's ability to boost not only skin's external defenses against harmful free radicals and environmental stressors, but also demonstrate that a standardized extract of pomegranate extract derived from the whole pomegranate fruit, has potent polyphenols that stimulate an increase in the body's own built-in antioxidant, glutathione and increases the topical SPF of sunscreens.
Historical Implications of Pomegranate
A native plant of Northern Africa, pomegranate (Punica granatum L) is one of the oldest natural remedies known to man. P granatum was mentioned in the papyrus Ebers of Egypt written in about 1550 BC. Hippocrates described its medicinal powers. Doctors in Greece prescribed pomegranate juice as a remedy with multiple activities: anti-inflammatory; as a potent anthelmintic (acting to expel or destroy intestinal worms), chronic diarrhea, dysentery, and cough suppressant.
In Mediterranean and Caucasian folk medicine, pomegranate extract is used to strengthen the human capillary system, for anti-atherosclerosis, as an anti-asthma agent, and for tonsillitis and bronchitis. Several scientific groups have reported anti-bacterial activity of polyphenols extracted from pomegranate and when mixed with aloe extract, pomegranate extract has been shown to activate bone tissue regeneration after injury.
Pomegranate extract is rich in a different group of polyphenolics, including anthocyanidins such as pentoside of malvidine and petunidin, delphinidin 3-glucoside and cyandin 3, 5 diglucoside. The analysis of biochemical composition performed at several Russion and Spanish Universities indicates that polyphenols (35-40%) and Ellagic Acid (5% -10%),are the main constituents of pomegranate extract.
Ellagic acid is a naturally occurring phenolic constituent of many plants that are important in the human diet, especially fruits and nuts. Interest in Ellagic acid has increase greatly during the last decade due to its effectiveness as an antimutagen and anticarcinogen and its potential as an inhibitor of chemically-induced cancer.
Efficiency of Pomegranate Extract, Topically and Internally
Topically, pomegranate extract is especially effective in protecting cells from free radical damage by inhibiting the formation harmful enzymes that cause cells to grow out of control. The ellagic acid, found within pomegranate extract is also thought to strengthen the cell membrane, making it less susceptible to free radical damage and preventing water loss. Such properties have important implications in terms of cancer prevention, as out-of-control cell division is a hallmark of cancer.
Indeed, research continues to support the anti-cancer and healing benefits of topically applied Pomegranate Extract. In a South Dakota State University study entitled Chemopreventative Effects of Pomegranate Seed Oil on Skin Tumor Development, Pomegranate Extract was applied to topical skin tumors on mice. After five weeks, the study concluded that topical application of pomegranate oil inhibited papilloma incidence and activity.
Researchers at the University of Wisconsin, evaluated pomegranate's anti-skin tumor effects by comparing topical application of pomegranate extract on neonatal mice against TPA-induced markers (12CONTACT: Harris Shepard Public Relations, +1-310-277-0437, for Murad, Inc.
URL: http://www.prnewswire.com
http://www.murad.com www.prnewswire.com
PR Newswire
06-06-06
LOS ANGELES, June 5, 2006 /PRNewswire via COMTEX/ -- The following paper was issued today by Murad, Inc.:
Pomegranate's Internal and External Role in
the War Against Environmental Aging and Disease
by Howard Murad, M.D.
Introduction
Each and every day, the skin -- our body's largest organ -- is bombarded with environmental assailants. In addition to external aggressors such as pollution, smoke, and ultraviolet radiation from the sun, the body's own metabolism causes cells to sustain one thousand hits of free radials daily, triggering the release of inflammatory mediators which break down collagen and damage cell barriers. In fact, internal damage caused by free radicals not only leads to the esthetic concern of wrinkled skin and hyperpigmentation, studies have shown this to be one of the main factors contributing to the formation of cancerous cells.
Since my early days as a dermatologist, I have been studying the ability of various antioxidants, such Vitamin C, Coenzyme Q 10, Alpha Lipoic Acid, and Vitamin E and herb extracts such as Burdock Root, Echinacea, Yellow Dock Root, and Grape Seed Extract to repair and protect the skin against such damage. While all are extremely beneficial, I found the most potent antioxidant power to date comes from Pomegranate Extract, and specifically the polyphenol, Ellagic Acid contained within the pomegranate.
In this paper, I would like to demonstrate pomegranate's ability to boost not only skin's external defenses against harmful free radicals and environmental stressors, but also demonstrate that a standardized extract of pomegranate extract derived from the whole pomegranate fruit, has potent polyphenols that stimulate an increase in the body's own built-in antioxidant, glutathione and increases the topical SPF of sunscreens.
Historical Implications of Pomegranate
A native plant of Northern Africa, pomegranate (Punica granatum L) is one of the oldest natural remedies known to man. P granatum was mentioned in the papyrus Ebers of Egypt written in about 1550 BC. Hippocrates described its medicinal powers. Doctors in Greece prescribed pomegranate juice as a remedy with multiple activities: anti-inflammatory; as a potent anthelmintic (acting to expel or destroy intestinal worms), chronic diarrhea, dysentery, and cough suppressant.
In Mediterranean and Caucasian folk medicine, pomegranate extract is used to strengthen the human capillary system, for anti-atherosclerosis, as an anti-asthma agent, and for tonsillitis and bronchitis. Several scientific groups have reported anti-bacterial activity of polyphenols extracted from pomegranate and when mixed with aloe extract, pomegranate extract has been shown to activate bone tissue regeneration after injury.
Pomegranate extract is rich in a different group of polyphenolics, including anthocyanidins such as pentoside of malvidine and petunidin, delphinidin 3-glucoside and cyandin 3, 5 diglucoside. The analysis of biochemical composition performed at several Russion and Spanish Universities indicates that polyphenols (35-40%) and Ellagic Acid (5% -10%),are the main constituents of pomegranate extract.
Ellagic acid is a naturally occurring phenolic constituent of many plants that are important in the human diet, especially fruits and nuts. Interest in Ellagic acid has increase greatly during the last decade due to its effectiveness as an antimutagen and anticarcinogen and its potential as an inhibitor of chemically-induced cancer.
Efficiency of Pomegranate Extract, Topically and Internally
Topically, pomegranate extract is especially effective in protecting cells from free radical damage by inhibiting the formation harmful enzymes that cause cells to grow out of control. The ellagic acid, found within pomegranate extract is also thought to strengthen the cell membrane, making it less susceptible to free radical damage and preventing water loss. Such properties have important implications in terms of cancer prevention, as out-of-control cell division is a hallmark of cancer.
Indeed, research continues to support the anti-cancer and healing benefits of topically applied Pomegranate Extract. In a South Dakota State University study entitled Chemopreventative Effects of Pomegranate Seed Oil on Skin Tumor Development, Pomegranate Extract was applied to topical skin tumors on mice. After five weeks, the study concluded that topical application of pomegranate oil inhibited papilloma incidence and activity.
Researchers at the University of Wisconsin, evaluated pomegranate's anti-skin tumor effects by comparing topical application of pomegranate extract on neonatal mice against TPA-induced markers (12CONTACT: Harris Shepard Public Relations, +1-310-277-0437, for Murad, Inc.
URL: http://www.prnewswire.com
http://www.murad.com www.prnewswire.com
