I tell you bros what I'll do...
It's been a while since I wrote an article on transdermals so it is time to get one posted about methods for increasing absorption and mechanisms of action. It will cover not only occlusive dressings but also topics such as heat, electro, and sonic penetration enhancement.
As a quick answer: use the saran wrap with a low alcohol recipe and it can be left applied for up to 12-24 hours. When used in this manner you can achieve a zero order absorption...and possibly get 60-75%
Simply apply a thick application on a body part that is easily wrapped (thigh, etc) and tuck the corners under the wrap for a secure fit. Wrap tightly but not so tight that it impedes circulation.
If one were to purchase one of my lotions it has inherent characteristics of an occlusive dressing without the sran wrap due to the methyl cellulose. What happens is that after the volatile ingredients (i-prop, etc) evaporate it leaves a thick coating that forms a matrix of PE's and PH's that effectively simulates an occlusive dressing. There are studies by 3M that indicate the rate of absorption is NOT dependent on the matrix but rather the rate limiting step is in crossing the skin...so forming a semi-solid matrix is of value for continuous flux.
Chemo