I hear many people complain about the muscle (i.e. size, strength) loss after getting off anabolic compounds. My question is ... why is there a loss? What physiologically causes this? Also, If there is an immediate or rapid reduction in size, strength, etc.. - will this not return after the body return to a more normal hormonal state? Our muscle has "memory" doesn't it? I did a couple of cycles of real gear a coupe of decades ago. Gained a lot of mass/strength. Then after a couple of years I stopped lifting... for about 18 years. I recently (about a year ago) started lifting again and have lost a ton (80 lbs) of fat and put on a bunch of muscle. My lifts are already near my personal bests and my body (while I still need to lose some more fat) appears to be nearly as muscular as it did back in "the good old days."
So what about this "memory"?
I can assure you that muscle memory is not a "theory", although once upon a time it was. Just like germs. But I'll get into that in a second. When using an anabolic compound you risk shutting down your natural testosterone, anywhere from a few weeks or in some cases, forever, this is known as testicular desensitization. So naturally, when you get off of your compound and your test levels are little to none, it is a must to use proper PCT (post cycle therapy) to keep most, if not all of your gains. Losing strength is going to happen when your test levels get low but that doesn't necessarily mean you have to lose size. If your PCT is strong and your caloric intake is high, you should be able to hold on to it. Infact, I just finished a Phera cycle and gained 10 lbs. dry, on cycle and another 3 lbs. post cycle. Now, lets get to bottom of this muscle memory.
Following a period of resistance training, MHC IIX content decreases from just over 9% to 2.0%, with a corresponding increase in MHC IIA (42% to 49%). Following detraining the amount of MHC IIX reach values that are higher than before and during resistance training, over 17%!
Myosin heavy chain isoforms, or MHCs, refer to the types of contractile protein you see in a given muscle fiber. MHCs determine how the muscle fiber functions. MHCs are what make a fiber "fast twitch", "slow twitch", or something in-between. Certain MHCs are known to undergo a change in response to resistance exercise. In this case, fibers that contain MHC IIX are fibers that aren’t really sure what kind of fiber they are until they are called to action. Once recruited, they become MHC IIAs. So, fibers containg MHC IIX proteins serve as a reservoir of sorts for muscle hypertrophy because the can transform themselves into fibers containing MHC IIX which grow easily in response to training. Resistance training decreases the amount of MHC IIX while reciprocally increasing MHC IIA content and during detraining an "overshoot" or doubling in the percentage occurs of MHC IIX isoforms.