Personal sleep formula ok?

[Sss23]

Just curious if this before bed is ok every night? I've had decent insomnia and this has really helped, just wondering if there are negatives to this?

500mg l tryptophan
200mg l theanine
Magnesium 400mg
3mg melatonin
10mg dhea


Thanks

 

[johnnyp]

5 HTP long term isn't great for your heart (Invalid Link Removed) since tryptophan is rate limited it might not carry the same risk but it's something that might be considered.

 

[LeanEngineer]

3 mg melatonin alone knocks me out haha I think it looks okay. I'd agree with the above statement as well.

 

[Jiigzz]

5 HTP long term isn't great for your heart (Invalid Link Removed) since tryptophan is rate limited it might not carry the same risk but it's something that might be considered.

How well does 5 HTP supplementation actually bind to that specific receptor subtype though? There are a lot of 5-HTP receptor subtypes, and 5 HTP 1a or non selectivity for 5 HTP2 (of which there are several subtypes) is far more common than 5 HTP 2b specifically as a molecular target. Although i'm hard pressed to find anything on 5 HTP and receptor selectivity specifically.

Curious if you have found evidence that details which receptor 5-HTP binds to readily.

 

[Synapsin]

How well does 5 HTP supplementation actually bind to that specific receptor subtype though? There are a lot of 5-HTP receptor subtypes, and 5 HTP 1a or non selectivity for 5 HTP2 (of which there are several subtypes) is far more common than 5 HTP 2b specifically as a molecular target. Although i'm hard pressed to find anything on 5 HTP and receptor selectivity specifically.

Curious if you have found evidence that details which receptor 5-HTP binds to readily.

I really wouldn't worry about it that much. Downstream effects of monoamine precursors would definitely result in more than the typical dose of 5-htp (although I'm not even sure why we are discussing this since tryptophan is not 5-htp).

 

[Jiigzz]

I really wouldn't worry about it that much. Downstream effects of monoamine precursors would definitely result in more than the typical dose of 5-htp (although I'm not even sure why we are discussing this since tryptophan is not 5-htp).

Do you happen to know what receptors 5-HTP supplementation targets? I can't find anything at all on receptor targets, only on end result.

 

[johnnyp]

How well does 5 HTP supplementation actually bind to that specific receptor subtype though? There are a lot of 5-HTP receptor subtypes, and 5 HTP 1a or non selectivity for 5 HTP2 (of which there are several subtypes) is far more common than 5 HTP 2b specifically as a molecular target. Although i'm hard pressed to find anything on 5 HTP and receptor selectivity specifically.

Curious if you have found evidence that details which receptor 5-HTP binds to readily.

Possibly helpful? Invalid Link Removed

I really wouldn't worry about it that much. Downstream effects of monoamine precursors would definitely result in more than the typical dose of 5-htp (although I'm not even sure why we are discussing this since tryptophan is not 5-htp).

I wasn't sure if tryptophan being a precursor would act similarly.

 

[Jiigzz]

Possibly helpful? Invalid Link Removed



I wasn't sure if tryptophan being a precursor would act similarly.

Perfect, thanks. Be good to see oral supplementation in humans or rats, but i'll take what I can get! Thanks for that!

 

[Synapsin]

Possibly helpful? Invalid Link Removed



I wasn't sure if tryptophan being a precursor would act similarly.

That dose in rats is at least 7x (at the 50 mg dose in rats) the normal amount humans supplement. I wouldn't worry about it, although nobody should be using a sleep aid permanently anyway since it is a bandaid solution.

 

[double s]

How much is all this running you?

 

[Sss23]

Maybe $30 a month, its low dose of everything

 

[double s]

Have a look at Muscle-Elements Amino PM, it has sleep aid and BCAA formula. One of the only ones I have tried that does have me waking up feeling all drunk.

 

[SJFIT]

I really liked really Rem 8.0 By Formutech Nutrition