Peptides in NASAL SPRAYS??

[Jinsun]

I'm seeing peptides being sold in the form of nasal sprays. Hexarelin, melanotan 2, etc ...

Does anybody have any experience with this? How is the bioavailability compared to SubQu injections?

Also, where does everybody order peptides in EU? Looking to stoxk up on cjcdac and hex for my upcoming cut ...

 

[Whisky]

I’ve heard of this and seem to recall bioavailability being very good but I’ve not used nasal and I don’t think there’s many that are available in that form....

99% of peptides come from China so that may present you issues (although the Chinese company i use didn’t seem to be bothered by the ban, the Corona virus has fucked things though

 

[Jinsun]

I wonder, if these are just reconstituted peptides poured in to a spray bottle ... If this is the case, we could make them our selfs. I mean, it goes without saying that having short half life peptides (hexarelina, ipamorelin, Mod GRF1, etc.) in a spray in your pocket, application of 3x a day (or more) would be totally effortless. Imagine going to do gym, you do your workout, and then it's time for a 30 min fasted cardio, you go to the locker, spray 100mcg's of hex in your nose, and of you go to an extremely effective fat burning cardio sesh ... That is, if they don't go bad seeing as you wouldn't have them stored in a cold refrigerator. Although you could have a small cold bag in your gym bag just for the peptides.

I mean, this sounds awesome.

*I also wonder what this means for your nasal cavity and sinuses health ...

 

[Jinsun]

I’ve heard of this and seem to recall bioavailability being very good but I’ve not used nasal and I don’t think there’s many that are available in that form....

Idk. it seems all that make sense (low half life ones) are more or less available.

 

[BarryScott]

I wonder, if these are just reconstituted peptides poured in to a spray bottle ...

That's literally all they are. It's just so they can sell more peptides to people scared of needles.

 

[RusTLad]

Not certain on the bioavailabilty of the intranasal delivery system but its worth noting that peptides used in the treatment of dementia use this system rather than injections. That might indicate its an effective delivery method for some peptides.

My main concern would whether the peptides are being shipped already reconstituted in the spray bottles. I would consider making my own peptide spray but I'm not sure if the usual reconstitution methods would be suitable?

 

[Renew1]

Not certain on the bioavailabilty of the intranasal delivery system but its worth noting that peptides used in the treatment of dementia use this system rather than injections. That might indicate its an effective delivery method for some peptides.

My main concern would whether the peptides are being shipped already reconstituted in the spray bottles. I would consider making my own peptide spray but I'm not sure if the usual reconstitution methods would be suitable?

Which Peptide sprays are used for dementia?

 

[RusTLad]

Which Peptide sprays are used for dementia?

In the reasrch it's referred to as R8-Aβ(25-35)-PEI, I imagine it has a brand name now that I'm not aware of.

That particular peptide is designed to stop or probably more accurately slow down the catabolism of APP in the brain and therfore prevent the build up of amyloid plaque. That being said this plaque build up is specific to Alzeheimers disease.

 

[Renew1]

In the reasrch it's referred to as R8-Aβ(25-35)-PEI, I imagine it has a brand name now that I'm not aware of.

That particular peptide is designed to stop or probably more accurately slow down the catabolism of APP in the brain and therfore prevent the build up of amyloid plaque. That being said this plaque build up is specific to Alzeheimers disease.

Thanks man.
Just trying to learn about something I don't know about.

 

[RusTLad]

Thanks man.
Just trying to learn about something I don't know about.

No problem it's not as sexy as anabolics but it's reasonably interesting.

 

[Jinsun]

Not certain on the bioavailabilty of the intranasal delivery system but its worth noting that peptides used in the treatment of dementia use this system rather than injections. That might indicate its an effective delivery method for some peptides.

My main concern would whether the peptides are being shipped already reconstituted in the spray bottles. I would consider making my own peptide spray but I'm not sure if the usual reconstitution methods would be suitable?

Maybe there is some other delivery method ... we don't know until somebody with more knowledge chimes in ...

Off course they are shipped reconstituted. Otherwise they would just be selling peptides in a sprey bottle instead of an ampule hehe

 

[Rebuild]

Maybe there is some other delivery method ... we don't know until somebody with more knowledge chimes in ...

Off course they are shipped reconstituted. Otherwise they would just be selling peptides in a sprey bottle instead of an ampule hehe

I've been pinning my peptides IM as recommended on another board. No more subq lumps, and theoretically the peak should be higher, which is all that matters with peptides. They won't be in your system long enough (other than cjc dac) to initiate more than one pulse.

 

[Jinsun]

I've been pinning my peptides IM as recommended on another board. No more subq lumps, and theoretically the peak should be higher, which is all that matters with peptides. They won't be in your system long enough (other than cjc dac) to initiate more than one pulse.

I'm happy for you ... ? Have anything to say about the topic at hand though?

 

[Rebuild]

I'm happy for you ... ? Have anything to say about the topic at hand though?

You were wondering about another delivery method, haha. I think in theory intranasal peptides should work, and I do not believe it would be damaging to the sinus cavity.

I've also heard of transdermal peptides...

 

[StatePlan1425]

Several studies have used this method as an alternative to expensive, pinned GH mostly in children. I believe the consensus is that its not as effective as sub q but still works. Personally, I can only see this as viable if you’re trying to hide your usage for whatever reason. Otherwise, sub q is pretty painless.

Intranasal administration of the GHRP hexarelin accelerates growth in short children - PubMed

The long-term GH/IGF-I stimulating, anabolic and growth promoting effects achieved by intranasal administration of this hexapeptide, seemingly without undesirable side-effects, suggests clinical potential for this new class of drugs.

www.ncbi.nlm.nih.gov

Treatment effects of intranasal growth hormone releasing peptide-2 in children with short stature - PubMed

Growth hormone-releasing peptide (GHRP)-2 is a synthetic six amino acid peptide that is a potent GH secretagogue. Although it shares no structural homology with GH-releasing hormone, in clinical studies its actions on the pituitary release of GH are similar. It is effective when administered...

www.ncbi.nlm.nih.gov

One-year intranasal application of growth hormone releasing peptide-2 improves body weight and hypoglycemia in a severely emaciated anorexia nervosa patient

In Japan, growth hormone releasing peptide-2 (GHRP-2) is clinically used as a diagnostic agent for growth hormone secretion deficiency, but the therapeutic application of GHRP-2 has not been studied in anorexia nervosa. GHRP-2 reportedly exhibits agonistic ...

www.ncbi.nlm.nih.gov

Dose-effect study of intranasal administration of growth hormone-releasing hormone-44-NH2 in healthy subjects - PubMed

Intranasal (in) administration of GH-releasing hormone-40- (GHRH-40) has been demonstrated to be efficient in stimulating GH secretion at doses equal to or higher than 30 micrograms/kg in man. We performed a dose-response study with GHRH-44-NH2 (GHRH) given by nasal spray and closely monitored...

www.ncbi.nlm.nih.gov

And many, many more...

 

[Jinsun]

Several studies have used this method as an alternative to expensive, pinned GH mostly in children. I believe the consensus is that its not as effective as sub q but still works. Personally, I can only see this as viable if you’re trying to hide your usage for whatever reason. Otherwise, sub q is pretty painless.

Intranasal administration of the GHRP hexarelin accelerates growth in short children - PubMed

The long-term GH/IGF-I stimulating, anabolic and growth promoting effects achieved by intranasal administration of this hexapeptide, seemingly without undesirable side-effects, suggests clinical potential for this new class of drugs.

www.ncbi.nlm.nih.gov

Treatment effects of intranasal growth hormone releasing peptide-2 in children with short stature - PubMed

Growth hormone-releasing peptide (GHRP)-2 is a synthetic six amino acid peptide that is a potent GH secretagogue. Although it shares no structural homology with GH-releasing hormone, in clinical studies its actions on the pituitary release of GH are similar. It is effective when administered...

www.ncbi.nlm.nih.gov

One-year intranasal application of growth hormone releasing peptide-2 improves body weight and hypoglycemia in a severely emaciated anorexia nervosa patient

In Japan, growth hormone releasing peptide-2 (GHRP-2) is clinically used as a diagnostic agent for growth hormone secretion deficiency, but the therapeutic application of GHRP-2 has not been studied in anorexia nervosa. GHRP-2 reportedly exhibits agonistic ...

www.ncbi.nlm.nih.gov

Dose-effect study of intranasal administration of growth hormone-releasing hormone-44-NH2 in healthy subjects - PubMed

Intranasal (in) administration of GH-releasing hormone-40- (GHRH-40) has been demonstrated to be efficient in stimulating GH secretion at doses equal to or higher than 30 micrograms/kg in man. We performed a dose-response study with GHRH-44-NH2 (GHRH) given by nasal spray and closely monitored...

www.ncbi.nlm.nih.gov

And many, many more...

Nice. I'll look into those.

I found a study (posted on reddit) that did a test on rats. Peptides disolved in water sprayed into the nasal cavities. Compared to injection. Now I know this are rats, but still, it's an indication.

Pretty poor bioavailability compared to inject:

Ipamorelin: 21%
GHRP-2: 53%
GHRP-6: 30%

 

[Jinsun]

Dose-effect study of intranasal administration of growth hormone-releasing hormone-44-NH2 in healthy subjects - PubMed

Intranasal (in) administration of GH-releasing hormone-40- (GHRH-40) has been demonstrated to be efficient in stimulating GH secretion at doses equal to or higher than 30 micrograms/kg in man. We performed a dose-response study with GHRH-44-NH2 (GHRH) given by nasal spray and closely monitored...

www.ncbi.nlm.nih.gov

"The magnitude of the GH peaks induced by in GHRH was significantly lower than that induced by iv GHRH."

Can't read the full article as it's not for free but this doesn't sound like it's over 50% bioavailability imo.

 

[Jinsun]

You were wondering about another delivery method, haha. I think in theory intranasal peptides should work, and I do not believe it would be damaging to the sinus cavity.

I've also heard of transdermal peptides...

I am quite against injectin watter (non oil) into the muscle. That's just asking for trouble and pain if you ask me. How long have you been doing IM with peptides? Is the bioavailability that much better IM compared to SubQ?

 

[Rebuild]

I am quite against injectin watter (non oil) into the muscle. That's just asking for trouble and pain if you ask me. How long have you been doing IM with peptides? Is the bioavailability that much better IM compared to SubQ?

Been doing IM peptides 3 weeks now, zero pain or issues. Why are you against injecting water into muscle? It's quite common with GH.

It seems more common than subq over on professional muscle, only anecdotal reports that it may increase the GH peak. So far I would continue IM just to prevent subq lumps around my navel. They were getting real bad pinning 3-4× a day and my abs look a lot better with no lumps.

 

[BCseacow83]

MT2 works very well in nasal spray. I made my own and would not trust a premixed for stability reasons.

 

[UNX]

IME, Melanotan II and oxytocin work fine as nasal spray. I used always physiological serum (0.9% NaCl) for injection.

 

[heebs10]

I wonder, if these are just reconstituted peptides poured in to a spray bottle ...

I’m sure that is exactly what they are.

 

[heebs10]

MT2 works very well in nasal spray. I made my own and would not trust a premixed for stability reasons.

What’s your concentration? 10 mg per 10 ml of xyz solution for example? Simply, how many mg per ml?

 

[heebs10]

IME, Melanotan II and oxytocin work fine as nasal spray. I used always physiological serum (0.9% NaCl) for injection.

No burning? And is that for subQ or IM? I give a lot of IM injections (as I am an RN), we reconstitute most with sterile water for injection (SWFI) assuming it requires reconstitution, as many already come diluted.

When IVs go bad and consequently subQ, it tends to burn and cause irritation, hence my curiosity.

 

[UNX]

No burning? And is that for subQ or IM? I give a lot of IM injections (as I am an RN), we reconstitute most with sterile water for injection (SWFI) assuming it requires reconstitution, as many already come diluted.

When IVs go bad and consequently subQ, it tends to burn and cause irritation, hence my curiosity.

In my case, I've only tried these peptides with nasal sprays, never SQ or IM. But at least GH segretagogues seem to be more cost-effective SQ than intranasal, so maybe just stick to injections in these kind of peptides.

 

[heebs10]

In my case, I've only tried these peptides with nasal sprays, never SQ or IM. But at least GH segretagogues seem to be more cost-effective SQ than intranasal, so maybe just stick to injections in these kind of peptides.

Got ya. Yeah in that case saline makes sense. I would never recommend injecting saline unless you are in a vein which doesn’t ever really apply in this community.

 

[Jinsun]

In my case, I've only tried these peptides with nasal sprays, never SQ or IM. But at least GH segretagogues seem to be more cost-effective SQ than intranasal, so maybe just stick to injections in these kind of peptides.

If the bioavailability from mice remotely correlates to humans, then it's really not cost effective. 5mg's of hex is beeing sold for (I think) 4x the price of normal hex in a vial. Doesn't make sense why the price jump, if the peptide is only disolved in saline or bac ...

I'm going to email them and ask about the details.