When I started on it I was doing 12.5 mgs in the morning then later in the day I would get waves of panic come over me and sweat this was at about 5pm. So I took 12.5 mgs more will when I seen my Dr. last Tue. My E2 levels were at 8 to low it's the low levels making me feel like this.
I am now in the process of lowering my Test C dose due to making too much E2 yes my levels are good but higher levels of E2 give me waves of Panic feeling even attacks. Now it looks like I drove my E2 down to low. I just read the other day at Dr. M forum going to low will cause Hot Flash's and this can feel like waves of Panic.
So I went from 200mgs every 3 days to 80 mgs I was told on my next shot if I have feeling of Panic or Hot Flash's on my next shot cut down to 60 mgs if this helps go back up to 80 on he next one.
Well doing this is working I have not needed to take anything to lower my Estradiol for 2 days now where before I was taking it everyday.
My Dr. use to use a lab with your ranges we stopped using them I now use Quest labs there top of range is 1100 I feel with a range of 1600 your always going to look low I did. You can't just go by lab numbers you need to go by how your feel.
I can tell you doing to much Test C to keep my numbers up drove up my E2 and I felt like crap from the high levels of Estraidol.
I gage my levels of Estradiol by my night time and morning wood but doing preg. and prog. cream I can get wood in my sleep with very low levels or Estraidiol the Prog. cream worked that good on me. So here I am thinking I feel like this the waves of panic feels because my Estardiol is still to high. But now I read that going to low can make you feel like this and my labs for Estradol were last at 8 test before this 7.
Here is what Dr. M says about this.
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DrMariano
Physician, Psychiatrist
Join Date: Mar 2009
Location: Carmel, California
Posts: 611 Re: Aromatase inhibitors and their effect on mood
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Quote:
Originally Posted by chaos
I use arimidex as part of my regimen. I hear some prefer aromsin (sp?). Is one better than the other for TRT, especially as it relates to mood?
Before I used the arimidex, I was very moody, but the arimidex resolved that.
Aromasin irreversibly binds to aromatase, knocking out the enzyme completely. Adjusting dose can be trickier than with Arimidex since the enzyme it binds to is completely inactivated. It is easy to knock out almost all of estradiol by having too large a dose with Aromasin. It is almost all excreted in about a week. Lowering estradiol dose excessively can bring about low estrogen problems including reduced libido, hot flashes, increased cholesterol, etc.
Arimidex competes with testosterone for binding to aromatase. Adjusting its effect involves increasing or decreasing the dose to get the desired binding effect on Aromatase to increase or decrease estradiol levels. The problem for Arimidex is that the duration of action very long. It takes up to 6 weeks to stabilize the dose and level of estradiol.
Both are very expensive medications. Aromasin has to be taken every day since its duration of action is much shorter than Arimidex. Arimidex can be taken once a week to keep stable blood levels.
I can't vouch for one or the other. Arimidex seems to be the one chosen by most practitioners. The ability to avoid daily dosing is a nice feature of Arimidex once steady levels of estradiol are established. One can, for example just take it on the day of a testosterone injection.
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Romeo B. Mariano, MD, physician, psychiatrist
Any information provided on Invalid Link Removed is for informational purposes only, is not medical advice, does not create a doctor/patient relationship or liability, is not exhaustive, does not cover all conditions or their treatment, and will change as knowledge progresses. Always seek the advice of your physician or other qualified health provider before undertaking any diet, exercise, supplement, medical, or other health program.
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Don't believe anything you hear and only half of what you see.
Phil
I like to know how low I am the morning of my next shot that is why my Dr. has me do labs the morning of my next shot but before my shot. And yes HCG helps keep your levels up but if you do HCG before your labs you don't know what your Test shot is doing.
To see your peak levels you would do labs the 3rd. day after your shot.
Your doing 125 mgs / week of Sustanon only hitting a level of 11 your 1) eating it up very fast or 2) need to try half the shot 2x's per week. We feel bad with levels fall this low you need to get up into the upper 1/3 of your labs range. A good level for you would be 20 to 23.
As for E2 levels you best level is 74.
I don't care what my peak levels are all I care about is how low I fall by my next shot. You need to get off this roller coaster ride.
When I was first diagnosed with low t I had severely reduced sensitivity in my whole lower pelvic region and almost no pleasure from orgasm. Both came back to about 85% of normal on 5 grams of androgel during the "kick" before my normal t shut off. Then the symptoms were back. After not getting high enough on 10g of androgel my doc brought it back down to 5 and started test cyp shots of 100mg a week. my sensitivity got back to about 50% then stopped. All my other symptoms disappeared within 2 weeks of my levels being normal. I am stuck here and have been for 4 months now. I am desperate and scared.
I went to the boston medical group and they did a vibration test on my penis and said the nerves were working. They did an ultrasound and said the bloodflow was good. I have no scar tissue that would interfere with sensation.
After turning to the net in desperation I saw PMgamer18 talk about his issues with sensitivity and ed. I checked and my estradiol was 40 on one test and 45 on another. It was 25 when I was on 5g of gel when I had a full blood panel. My only hope for now is to try to get it down to 25 again like PMgamer18 suggested and hope it works.
I tried with Femara 8 weeks ago and it obliterated my E2 now it is back above 30 so I want to try the 1/4 mg of arimidex.
Where does shbg fit into all this? please help me understand.
I apologize for the long post.
I will ask my endo if I can test my shbg when I see him tuesday. I am so thankful I have the support of people on this post. Thank you The Matrix. Do you treat a lot of trt guys?
Do you agree that shbg and or E2 levels may be causing the sensitivity issue? Are there other things I should look for?
Thank you again for your help.
He won't admit he doesn't know what to do he keeps saying just wait and see it takes a while. After months of waiting I finally went on here out of frustration! He should admit he doesn't know what to do and refer me to someone who does. Ugh!
Thank you The Matrix.
This doctor is an editor and chief of the Journal of Sexual Health and seems to know his stuff. His receptionist says he looks at balances of hormones not just testosterone. He looks at E2, prolactin, shbg, calculates your bio available testosterone, looks at dht, and adrenal hormones that can affect sexual function. (My doc looked at these one time in the beginning then just looked at free and total t). Many men come to him on trt with ED or sensitivity/orgasm issues. She says he has helped many of them regain full function. If he doesn't work I am going to Dr. Mariano, the only reason I am not seeing Dr. Mariano already is he is so far away (7 hour drive). This guy is a 1 1/2 hour drive.
It is hard not to be depressed about this stuff. I am glad I have someone to message who understands. I am sorry you had to waste so much time and money on this.
Hopefully I won't have to repeat the experience, but we will see.
Not sure if he looks at the other things or root causes. I will know more when I see him. FYI I eat a balanced healthy diet, maintain a healthy weight and do weights and cardio 3 times a week at the gym. I also take a multi vitamin and mineral, calcium and omega 3 fatty acids every day. Not sure what else to do in this area.
I had a free 10 minute phone consult with this doctor today. I was on Prozac for 2 years and when I came off it my sensitivity and orgasmic pleasure did not return. That was what eventually lead me to get a blood test a year and a half later and found my total t was 300 on one test then 280 on another. I discovered I had low T and started this journey.
This doctor said he thinks I have post SSRI sexual dysfunction and that is why it won't come back.
He also said at 37 and still wanting to have kids testosterone is the wrong thing to give me. He wants me to use Clomid to stimulate my natural production. He said test over the long term might damage my ability to have kids. What do you guys think?
I am more confused than ever! Has anyone ever heard of Post SSRI sexual dysfunction?
UGH!!!!!!!!
That is very helpful The Matrix I feel better about seeing this guy now.
Have you ever heard of Post SSRI sexual dysfunction?
They have a forum and they talk about reduced sensitivity and orgasmic pleasure like I have persisting after they come off the anti-depressants. What is frustrating is other guys on trt have the same symptoms on here when their E2 or prolactin or adrenal hormones are off.....even if they are in the "normal ranges".
BTW the doctors name is Irwin Goldstein a well know sexual dysfunction expert. He runs a sexual dysfunction clinic in San Diego CA
I read that if you take vitamin E for about 1-2 weeks starting, you will increase your semin amount at least double, if not triple! You are supposed to keep taking and it will help you orgasm faster too. I do not now however if this part is true, but it you put all the facts together, combined with another little special ingredient of your choice, I think that will be the end of your problems!!
Chris L
Fullproofdistributions.com
I just went to him a few weeks ago. He deal via phone callI am sick of my endo not knowing what he is doing. I am going to try a guy named Irwin goldstein he runs a sexual health clinic in Sand Diego. Have you heard of him?
I wish I lived near Dr. Crisler or you. I want to try hcg but my endo said its dangerous with no long term studies and should only be used if I want to have kids.
I can't wait to see if this new doc is better. He seems to pay more attention to the big hormonal picture from his site. I hope that is the case.