By supps if you are referring to supports supps... It's up to you. Some people feel liver support supps like milk thistle diminish the effect of SD if taken to close together. Depends on what your running. If referring to normal pre workout or post workout supps... That again is up to you, your goals and overall health. BP will be an issue with PWO on cycle obviously. Horrible way to state a question if looking for advice also leads me to believe your not ready for an SD cycle. Have fun