meowmeow
Active member
- Awards
- 1
I wrote this for the injectables section but is really relevent for this section as most gear is bought from Underground labs which homebrew with oils.
"Squalene can generate antibodies which can result in Auto Immune Disease. So they attack our own bodies with our own immune system and this can effect nerve, it can effect cardiac tissue, it can effect skin… So Squalene is a no, no. It's not been recommended for use in human vaccines, its been tried in a lot of animal experiments… You don't need very much, the immune system is extremely sensitive at that sort of level we're talking about… An almugram is a millionth of a gram, we're talking about a thousand billions to the gram…the body does respond to these very tiny amounts of some substances and so I am really concerned." - Professor Malcolm Hooper (scientist who sits on two independent committees set up by the U.K. government to investigate illnesses of Gulf war veterans) 1
What is Squalene?
Squalene is a naturally occurring substance. It is found in abundance in shark liver oil and some vegetable oils such as olive oil. It is often added to cosmetics and nutritional supplements. Squalene is even produced in the human body by the liver to aid the breakdown of cholesterol and to combat physical injuries. It was thought that since squalene is safely ingested and is produced by the body itself it might be safe to use in vaccines as an adjuvant or booster to increase the potency of the vaccine itself.
Is it Safe?
Animal studies have demonstrated that squalene adjuvants may generate unwanted side effects, including autoimmune versions of arthritis, multiple sclerosis and other conditions. 2 The FDA has never approved the general use of any vaccine containing squalene.
However the possibility was raised that it was used illegally on military personnel, when a professor at Tulane University conducted a study of more than 400 Gulf War veterans suffering from Gulf War syndrome (a condition characterized by general fatigue, joint pain, memory loss, an inability to concentrate, and other ailments). Ninety-five percent of those who exhibited symptoms of Gulf War Syndrome were found to have high levels of squalene antibodies in their blood. Many of the samples that tested positive for squalene were taken from soldiers who were not deployed to the Persian Gulf but still received the anthrax vaccine. 3 These findings were confirmed and published the following year. 4
Eventually the FDA confirmed that squalene was present in the anthrax vaccine administered to U.S. military personnel and after years of denial the U.S. military finally admitted as much. While the story is both fascinating and frightening it is not meant to be covered here. The evidence that squalene may be responsible for Gulf War syndrome is covered in a book by Gary Matsumoto. 5 The military's response may be found in their Anthrax Q&A at their website. 6
Why steroid users should be concerned?
Simply put, squalene consumed orally is safe and has benefits to the body. It may play a part in cardiovascular health and cancer prevention. However squalene injected into the bloodstream appears to not be safe as the body may produce antibodies which may unfortunately attack tissue that contains body-produced beneficial squalene. This in turn could lead to ongoing auto-immune diseases. It is the propensity for injected squalene to activate the defense mechanisms which result in the body attacking itself that may make it dangerous to use an injectable solution which contains squalene.
Olive oil contains a significant amount of squalene (0.7%) 7 whereas oil derived from seeds (cottonseed, grapeseed, sesame, etc.) contains very little. This is a concentration that could trigger the body to produce antibodies. It may be that the squalene in olive oil does not produce such a response but until that is demonstrated it may be prudent to avoid using olive oil in any homebrewed injectable solution. Due to the low concentration of squalene in seed oils one might consider them as a better alternative. The best option would seem to be to avoid oils with any squalene present.
All of this is conjecture at this point. Until someone actually has their blood tested for anti-bodies after olive oil injection it will remain so.
Notes:
1 Interview appeared as part of story aired on "Tonight with Trevor McDonald March 17, 2003 on ITV1
2 For more information concerning the induction of lupus autoantibodies by adjuvants contact Minoru Satoh, research associate professor at the Division of Rheumatology and Clinical Department of Medicine, University of Florida, P.O. Box 100221, 1600 SW Archer Road, Gainesville, FL, USA 32610-0221, for the details of research carried out by himself and fellow researchers Y, Yoshida H, Behney KM, Mizutani A, Akaogi J, Nacionales DC, Lorenson TD, Rosenbauer RJ, Reeves WH.
3 Mackenzie D., "Victims of vaccines", New Scientist April 10, 1999.
4 Asa PB, Cao Y, Garry R. "Antibodies to squalene in Gulf War syndrome", Experimental and Molecular Pathology February 2000;68(1):55-64.
5 Vaccine A : the covert government experiment that's killing our soldiers and why GI's are only the first victims, Gary Matsumoto; New York : Basic Books, c2004
6 http://www.anthrax.osd.mil/resource/qna/qaAll.asp?cID=319
7 Ibid, for olive oil concentration
Why Olive Oil may be a harmful choice for injectable solution
Meowmeow
Feb 27, 2006
Meowmeow
Feb 27, 2006
"Squalene can generate antibodies which can result in Auto Immune Disease. So they attack our own bodies with our own immune system and this can effect nerve, it can effect cardiac tissue, it can effect skin… So Squalene is a no, no. It's not been recommended for use in human vaccines, its been tried in a lot of animal experiments… You don't need very much, the immune system is extremely sensitive at that sort of level we're talking about… An almugram is a millionth of a gram, we're talking about a thousand billions to the gram…the body does respond to these very tiny amounts of some substances and so I am really concerned." - Professor Malcolm Hooper (scientist who sits on two independent committees set up by the U.K. government to investigate illnesses of Gulf war veterans) 1
What is Squalene?
Squalene is a naturally occurring substance. It is found in abundance in shark liver oil and some vegetable oils such as olive oil. It is often added to cosmetics and nutritional supplements. Squalene is even produced in the human body by the liver to aid the breakdown of cholesterol and to combat physical injuries. It was thought that since squalene is safely ingested and is produced by the body itself it might be safe to use in vaccines as an adjuvant or booster to increase the potency of the vaccine itself.
Is it Safe?
Animal studies have demonstrated that squalene adjuvants may generate unwanted side effects, including autoimmune versions of arthritis, multiple sclerosis and other conditions. 2 The FDA has never approved the general use of any vaccine containing squalene.
However the possibility was raised that it was used illegally on military personnel, when a professor at Tulane University conducted a study of more than 400 Gulf War veterans suffering from Gulf War syndrome (a condition characterized by general fatigue, joint pain, memory loss, an inability to concentrate, and other ailments). Ninety-five percent of those who exhibited symptoms of Gulf War Syndrome were found to have high levels of squalene antibodies in their blood. Many of the samples that tested positive for squalene were taken from soldiers who were not deployed to the Persian Gulf but still received the anthrax vaccine. 3 These findings were confirmed and published the following year. 4
Eventually the FDA confirmed that squalene was present in the anthrax vaccine administered to U.S. military personnel and after years of denial the U.S. military finally admitted as much. While the story is both fascinating and frightening it is not meant to be covered here. The evidence that squalene may be responsible for Gulf War syndrome is covered in a book by Gary Matsumoto. 5 The military's response may be found in their Anthrax Q&A at their website. 6
Why steroid users should be concerned?
Simply put, squalene consumed orally is safe and has benefits to the body. It may play a part in cardiovascular health and cancer prevention. However squalene injected into the bloodstream appears to not be safe as the body may produce antibodies which may unfortunately attack tissue that contains body-produced beneficial squalene. This in turn could lead to ongoing auto-immune diseases. It is the propensity for injected squalene to activate the defense mechanisms which result in the body attacking itself that may make it dangerous to use an injectable solution which contains squalene.
Olive oil contains a significant amount of squalene (0.7%) 7 whereas oil derived from seeds (cottonseed, grapeseed, sesame, etc.) contains very little. This is a concentration that could trigger the body to produce antibodies. It may be that the squalene in olive oil does not produce such a response but until that is demonstrated it may be prudent to avoid using olive oil in any homebrewed injectable solution. Due to the low concentration of squalene in seed oils one might consider them as a better alternative. The best option would seem to be to avoid oils with any squalene present.
All of this is conjecture at this point. Until someone actually has their blood tested for anti-bodies after olive oil injection it will remain so.
Notes:
1 Interview appeared as part of story aired on "Tonight with Trevor McDonald March 17, 2003 on ITV1
2 For more information concerning the induction of lupus autoantibodies by adjuvants contact Minoru Satoh, research associate professor at the Division of Rheumatology and Clinical Department of Medicine, University of Florida, P.O. Box 100221, 1600 SW Archer Road, Gainesville, FL, USA 32610-0221, for the details of research carried out by himself and fellow researchers Y, Yoshida H, Behney KM, Mizutani A, Akaogi J, Nacionales DC, Lorenson TD, Rosenbauer RJ, Reeves WH.
3 Mackenzie D., "Victims of vaccines", New Scientist April 10, 1999.
4 Asa PB, Cao Y, Garry R. "Antibodies to squalene in Gulf War syndrome", Experimental and Molecular Pathology February 2000;68(1):55-64.
5 Vaccine A : the covert government experiment that's killing our soldiers and why GI's are only the first victims, Gary Matsumoto; New York : Basic Books, c2004
6 http://www.anthrax.osd.mil/resource/qna/qaAll.asp?cID=319
7 Ibid, for olive oil concentration
