Nolvadex Permanently Reduces IGF-1?

Sytic

New member
First thread, whats up?
I'm 24 and have been lifting for close to 6 years.
I've ran one ProHormone cycle in the past (halodrol) and thinking about doing a superdrol (methasterone) cycle considering I've hit a plateau.
I'm considering using Nolvadex for 4 weeks and ATD alongside it, slowly ramping up the dosage on the last two weeks.
I literally just read hundreds of threads across every forum claiming Nolvadex reduces IGF-1 upto 30%.
That **** makes me less tempted to cycle.
Is the lowered IGF only temporary whilst you're taking Nolvadex or a permanent side affects afterwards?
Sorry about my english, appreciate it.
 
Sytic said:
First thread, whats up?
I'm 24 and have been lifting for close to 6 years.
I've ran one ProHormone cycle in the past (halodrol) and thinking about doing a superdrol (methasterone) cycle considering I've hit a plateau.
I'm considering using Nolvadex for 4 weeks and ATD alongside it, slowly ramping up the dosage on the last two weeks.
I literally just read hundreds of threads across every forum claiming Nolvadex reduces IGF-1 upto 30%.
That **** makes me less tempted to cycle.
Is the lowered IGF only temporary whilst you're taking Nolvadex or a permanent side affects afterwards?
Sorry about my english, appreciate it.
Click to expand...

I wouldn't run superdrol as my second cycle, you could run epistane again but maybe at 6 weeks with a test base or dmz, promag, methyldiazirinol etc
 
anyone who decides to run superdrol is risking their health for some temporary gains. I know the temptation is so strong but superdrol was never initially released as a steroid because of it's major health risks. You're basically poisoning yourself to see an increase in strength and size. It wasn't until "prohormones" started popping up on the market that companies decided to dust this compound off and release it as a muscle building pill to the public.
Lots of people claim to love it because of the quick gains but anyone concerned about their overall health should avoid it.
 
Imo, it could possibly lower it while taking, but Nolva is the most popular serm besides clomid. There are tons of huge guys out there that I'm sure have taken Nolva and they obviously haven't had any issues because of what you have proposed.
 
Sytic said:
I love all the answers guys, but nobody really answered my question.
Click to expand...

We aren't doctors or scientists and can't accurately answer your question.
If you are scared of the risk, don't run the compound.
You can break your "plateau" through a variety of other ways.
 
Lol I didn't claim you was a scientist, I was just curious.

Doesn't take a scientist to share information they know buddy.
 
Sytic said:
Lol I didn't claim you was a scientist, I was just curious.

Doesn't take a scientist to share information they know buddy.
Click to expand...

Superdrol is too strong for a second cycle, maybe try dmz instead. As far as nolva reducing igf, i ran nolva for my epistane pct and didn't notice a difference, but thats just based off how I feel. If your afraid of igf levels reducing then you could try clomid or torem
 
Sytic said:
Lol I didn't claim you was a scientist, I was just curious.

Doesn't take a scientist to share information they know buddy.
Click to expand...

I'm telling you that no one on this forum (that I am aware of) is qualified to give you an accurate answer. It will all just be speculation.
Just run the sdrol if you want and get lab work done and report back. Maybe you can educate us with an answer to your own question :)
 
I'm not sure if anyone knows, to what extend exactly, how this would translate to men, but nolva has been shown numerous times to decrease IGF-1 levels by about ~30% and have increasing/decreasing effects on the IGF system in general. Interestingly, it's been speculated that high levels of IGF-1 can actually lead to nolva resistance. Again, it's really hard to know if nolva would have the same effect on men considering our bodies work much differently especially at the hormonal level. As far as I know the only clinical data showing correlations between nolva and decreased IGF-1 levels were done on women.
 
Sytic said:
I love all the answers guys, but nobody really answered my question.
Click to expand...

The IGF-1 reduction is only temporary. This is also the main reason why Tamoxifene shouldn't be used during cycles as an estrogen blocker. For this case, there are AI out there (some are very, very strong. Watch out).
The lower IGF-1 level is not that serious. The main problem after a cycle is getting old sexual hormone values to "keep" the gained muscle mass. IGF-1 in this case is only subordinated.
 
Taken from MrKleen73's post.

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Anti-Estrogens And IGF-1 Production
GH (Growth Hormone) is like a master hormone for tissue growth and fat regulation due to its own intrinsic qualities and its propensity to be converted into or trigger the production and release of Growth Factors. Of these Growth Factors, one of the best known in regard to muscle growth is IGF-1 (Insulin-Like Growth Factor-1).

As most are aware by now, IGF-1 is a powerful anabolic and anti-catabolic hormone. Whether in pre-contest mode or packing on the mass, the amount of circulating and stored IGF-1 an athlete maintains plays a powerful role in the results achieved. Obviously as IGF-1 levels decrease so does the potential for packing on the beef, and the amount of lean tissue lost during calorie-restricted periods increases as well. (Not good)

Estrogen, and more so estradiol, can trigger GH release from the pituitary gland. Aromatase inhibitors decrease the amount of circulating estrogen/estradiol and estrogen receptor antagonist keep estrogen out of the specific pituitary receptors. So in many regards the use of anti-estrogens can effect IGF-1 production and in some cases affect the number of IGF-1 receptors our tissues posses.

Product Effect Percentage
Formestane/
4-Androstenoldione Increases IGF-1 26%
-------------------------0----------------------------------0-----------------------0
Femara/
Letrozol Increases IGF-1 24%
-------------------------0----------------------------------0-----------------------0
Arimidex/
Anastrozole Decreases IGF-1 18%
-------------------------0----------------------------------0-----------------------0
Nolvadex/
Tamoxifen Decreases IGF-1 23.5%
-------------------------0----------------------------------0-----------------------0
Faslodex/
Fulvestrant Decreases IGF-1 70%
-------------------------0----------------------------------0-----------------------0
Cytadren/
Aminoglutethimide Increases IGF-1 27%
-------------------------0----------------------------------0-----------------------0
Aromasin/
Exemestane Increases IGF-1 28%
-------------------------0----------------------------------0-----------------------0
 
Once the Nolva cycle is finished, would thy IGF return to normal levels or remain decreased?
Excellent answer
 
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