Hello everyone.
Someone here mentioned NO as an aging factor.
May long term use of citrulline or agmatine decrease the endothelium's capacity to synthesize NO without exogenous support?
Can NO precursors supplementation affect the endothelium's or blood vessels' natural capacities in the future?
A big thank you.
My assumption would be, to some degree, yes - they can effect endothelial function (not just capacity). Some of these improvements, however, could be beneficial depending on which NO precursor you are talking about.
Arginine itself has been hypothesized to have anti-aging function and as part of a food supply, it is used long-term by everyone (until they die).
Agamatine has been shown in studies to help prevent, or maybe even reverse, cognitive decline with age, Alzheimer's and dementia (in rats at least). It has also been shown to be neuroprotective in ischemic events. It also has some function to decrease blood glucose levels, decrease anxiety, and improve the function of other drugs.
Not sure on nitrates, and I think there is some conflicting evidence - but our guts also make nitrates/nitrites.
It's always good to cycle, but something like agmatine I wouldn't worry about. Of course, our bodies have a goal at hand and we usually have 2-3 pathways to achieve that goal - and I am starting to believe that the over-use of a single pathway is what often leads to issues. Change is a good thing.