Nitrates and Enhanced Contractile Properties in Muscle

Resolve10

Well-known member
So I had trouble digging back through previous threads to find where, but I know @3ChainedAminos had posted questions about Calcium release and pumps.

Amentoflavone is often (rightfully) brought up in regards to this, but Nitrates may have a (complimentary) role on this as well.

Mr.Cooper had a thread highlighting this years ago (which also highlighted their "synergy" and hence inclusion in PES Enhanced all those years ago), but a recent study I saw today re-jogged that memory for me: https://journals.lww.com/acsm-msse/abstract/9900/beetter_aging__short_term_dietary_nitrate.760.aspx

Now the conclusions state benefits for older compared to younger individuals, but I haven't had the time to really dig into the study. It mostly just felt relevant to previous discussions and as a friendly reminder that there might also be benefits to certain things at different time points in ones training career (or to keep these kinds of things in mind). All sorts of things to keep in mind in regards to various aspects of the study, but again just found the main thread interesting enough to share.
 
This is definitely more in-line with what I was thinking about. “skeletal muscle contractile function” so anything to help with that and increasing of the force/strength of contraction. I called it the “cramp feeling” lol
 
So I went down a rabbit hole on chat gpt(just discovered ChatGPT a few days ago lol) and it’s looking like what I’m trying to specifically find is more complex than I thought. Theres way more physiological pathways than I thought in the entire muscle contraction process. With that said I did a little more digging on the contraction coupling phase because I feel like that’s the process that’s gonna help with the “cramp feeling” or actual strength of contraction. I looked into the calcium release into muscle cells from the sarcoplasmic reticulum, well before that, you need a trigger in voltage sensitive proteins in the t tubules. Went into the voltage sensitive proteins and got to voltage gated sodium channels. Which mostly involves NaV1.4 isoform, well I searched what could help with these pathways and well there wasn’t much after that. It’s basically saying that trying to mess with Nav1.4 should be taken with caution and that it can have pretty bad adverse effects. Most of this was searched on google and ChatGPT so obviously taking it was a grain of salt. Gonna try and take more cracks at it and just keep digging, may never get an answer I want, but at least it gives me something healthier to study instead of all the other crap I look up on the internet. Also I apologize in advance for my run on sentences and bad grammar. It drives my wife nuts but I’m working on it. I’m basically an old
Man with technology.
 
I’ll be honest idk if chasing fine physiological processes (especially with ChatGPT) down a rabbit hole of terminology is going to lead you anywhere. Idk the best way to explain what I want to say, but these things are “messy” and trying to follow singular pathways just doesn’t seem like it will end where you are hoping.

I’m sure there might be things that will broadly help, but manipulations to exercise selection and execution will likely influence it more.
 
Resolve10 said:
I’ll be honest idk if chasing fine physiological processes (especially with ChatGPT) down a rabbit hole of terminology is going to lead you anywhere. Idk the best way to explain what I want to say, but these things are “messy” and trying to follow singular pathways just doesn’t seem like it will end where you are hoping.

I’m sure there might be things that will broadly help, but manipulations to exercise selection and execution will likely influence it more.
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I think you’re right because when I started looking up things to increase those specific pathways, it got murky. Well at least through ChatGPT, which I know I’ve been using too much lol, I run out of messages very quickly.
 
3ChainedAminos said:
I think you’re right because when I started looking up things to increase those specific pathways, it got murky. Well at least through ChatGPT, which I know I’ve been using too much lol, I run out of messages very quickly.
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Grok has been my go to over chatgpt recently. I've actually had a better overall experience and results with it.
 
So in the APT Elite contains Peak ATP and their write up online includes a claim about increased Calcium pool, which does seem directly relevant to this thread.

I think it serves as a good reminder how (which I mentioned somewhere before) if we want to improve something (calcium for muscle contraction) it doesn't always mean to directly intake that thing (more calcium) when it may be improved with the consumption of something else (in this case Peak ATP increasing ATP and ATP increases leading to more Calcium).

The full paper is available to read and covers this stuff broadly (and narrowly in some cases): https://journals.physiology.org/doi...l_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org
 
Resolve10 said:
So in the APT Elite contains Peak ATP and their write up online includes a claim about increased Calcium pool, which does seem directly relevant to this thread.

I think it serves as a good reminder how (which I mentioned somewhere before) if we want to improve something (calcium for muscle contraction) it doesn't always mean to directly intake that thing (more calcium) when it may be improved with the consumption of something else (in this case Peak ATP increasing ATP and ATP increases leading to more Calcium).

The full paper is available to read and covers this stuff broadly (and narrowly in some cases): https://journals.physiology.org/doi/full/10.1152/physrev.00040.2008?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org
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Very interesting, I’m also loving a photo someone shared in another thread of ElevATP and all the trace minerals in it.
 
3ChainedAminos said:
Very interesting, I’m also loving a photo someone shared in another thread of ElevATP and all the trace minerals in it.
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It's X's (Formerly Twitter's) version of AI. Built into the X app if you already have it.
 
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