yeah you would piss the pot soaked lipids out sooner, so you would not want to take it directly before cause it would actually increase levels in you urine, but if you have a day or two to rid toxins it works great with drinking a lot of water... also i think taking too much niacin can be harmful to your kidneys so i would be wary of mega-dosing schemes..Also i'm talking about the niacin that causes the "flush" felling, not the new "no flush" ****e. sorry to be so off topic but seems sort of(?) relevant