Lately, I've become interested in the topic of neurosteroids.
https://en.wikipedia.org/wiki/List_of_neurosteroids
I've been doing a bit of research on this one compound called Cyclopregnol that was researched in the 1950s for "undefined mechanism of action; developed as a "psychotropic agent" for the treatment of "mental disorders" such as schizophrenia in the 1950s".
https://en.wikipedia.org/wiki/Cyclopregnol
I just find these compounds very interesting for their potential to have either cognitive benefits or to help with depression, anxiety, mood, and etc.
I'll link to the studies I found on the compound, but they're all from the 1950s which is ancient history in terms of mental health. There are many other neurosteroids out there, some of them were investigated and many were not. DHT (dihydrotesosterone) is one of the most potent neurosteroids, and it's one men make in their body from testosterone via conversion through the 5 alpha reductese enzyme.
Pregnolone is another very interesting neutosteroid. It's the first steroid for conversion from cholesterol. I've actually tried pregnenolone. It's big right now in research for postpartum depression. They inject the person with a derivative of pregnenolone called allopregnolone.
Apparently, it's a pretty penny to get this treatment done. They do several rounds of injection into the patient and it can cost up to $10k from what I remember.
Pregnolone is also being investigated as a cure for "loneliness".
I actually told my psych about it and although it didn't work for me, he said one guy he recommended it to was immediately cured of his depression and anxiety. It's sold OTC as a dietary supplement, so you can try it yourself if you're the experimental type. https://*******/2TqH9QF
6p-Hydroxy-3 : 5-cyclopregnan-20-me and Some Related compounds
http://www.mediafire.com/file/ti6he128572bzbc/patel1957.pdf/file
Treatment of Acute Mental Disorders with an Adrenal Steroid
http://www.mediafire.com/file/4xdzn9j4098oiuj/loranger1968.pdf/file
6/3-HYDROXY-3 :5-C YCLOPREGNAN-20-ONE IN MENTAL STATES
http://www.mediafire.com/file/pxiw1y2f8wzdby7/hardwick1957.pdf/file
There are many other neurosteroids out there, some have been investigated, but many have not. I'd love to have a discussion about neurosteroids and their potential for treating mental health issues and other attributes they might have.
-SS
https://en.wikipedia.org/wiki/List_of_neurosteroids
I've been doing a bit of research on this one compound called Cyclopregnol that was researched in the 1950s for "undefined mechanism of action; developed as a "psychotropic agent" for the treatment of "mental disorders" such as schizophrenia in the 1950s".
https://en.wikipedia.org/wiki/Cyclopregnol
I just find these compounds very interesting for their potential to have either cognitive benefits or to help with depression, anxiety, mood, and etc.
I'll link to the studies I found on the compound, but they're all from the 1950s which is ancient history in terms of mental health. There are many other neurosteroids out there, some of them were investigated and many were not. DHT (dihydrotesosterone) is one of the most potent neurosteroids, and it's one men make in their body from testosterone via conversion through the 5 alpha reductese enzyme.
https://en.wikipedia.org/wiki/Dihydrotestosterone#Biological_activityMetabolites of DHT have been found to act as neurosteroids with their own AR-independent biological activity.[18] 3α-Androstanediol is a potent positive allosteric modulator of the GABAA receptor, while 3β-androstanediol is a potent and selective agonist of the estrogen receptor (ER) subtype ERβ.[18] These metabolites may play important roles in the central effects of DHT and by extension testosterone, including their antidepressant, anxiolytic, rewarding/hedonic, anti-stress, and pro-cognitive effects.[18][19]
Pregnolone is another very interesting neutosteroid. It's the first steroid for conversion from cholesterol. I've actually tried pregnenolone. It's big right now in research for postpartum depression. They inject the person with a derivative of pregnenolone called allopregnolone.
Allopregnanolone-based treatments for postpartum depression: Why/how do they work?
Recent FDA approval of an allopregnanolone-based treatment specifically for postpartum depression, brexanolone, now commercially called Zulresso®, is an exciting development for patients and families impacted by postpartum depression and allows ...
www.ncbi.nlm.nih.gov
Apparently, it's a pretty penny to get this treatment done. They do several rounds of injection into the patient and it can cost up to $10k from what I remember.
Pregnolone is also being investigated as a cure for "loneliness".
Scientists are working on a pill for loneliness
Modern life has led to greater isolation, which can fuel an array of disorders. If there are medications for social pains like depression and anxiety, why not loneliness?
www.theguardian.com
I actually told my psych about it and although it didn't work for me, he said one guy he recommended it to was immediately cured of his depression and anxiety. It's sold OTC as a dietary supplement, so you can try it yourself if you're the experimental type. https://*******/2TqH9QF
6p-Hydroxy-3 : 5-cyclopregnan-20-me and Some Related compounds
http://www.mediafire.com/file/ti6he128572bzbc/patel1957.pdf/file
Treatment of Acute Mental Disorders with an Adrenal Steroid
http://www.mediafire.com/file/4xdzn9j4098oiuj/loranger1968.pdf/file
6/3-HYDROXY-3 :5-C YCLOPREGNAN-20-ONE IN MENTAL STATES
http://www.mediafire.com/file/pxiw1y2f8wzdby7/hardwick1957.pdf/file
There are many other neurosteroids out there, some have been investigated, but many have not. I'd love to have a discussion about neurosteroids and their potential for treating mental health issues and other attributes they might have.
-SS