NeuroSteroids- intranasal pregnenolone

BrainWavez

New member
Hi! Does anyone have experience with Neurosteroids? Like DHEA, Pregnenolone Allopregnenolone,…?

I found a study Invalid Link Removed with intranasal pregnenolone and was going to try to make a nasal spray. They are using a proprietary gel.

I’m not sure how to dissolve it. I’m thinking ethanol and then distilled water.

Anyone tried anything like this?
 
iconic formulations has transdermal pregnenolone [neuro p5]....i've applied it to forehead and temples before and it was a pretty nice buzz affect---i'm a fan of preg, maybe @delsolrob or @nostrum420 could give you some idea's---a nasal preg sounds interesting.
 
BrainWavez said:
Hi! Does anyone have experience with Neurosteroids? Like DHEA, Pregnenolone Allopregnenolone,…?

I found a study Invalid Link Removed with intranasal pregnenolone and was going to try to make a nasal spray. They are using a proprietary gel.

I’m not sure how to dissolve it. I’m thinking ethanol and then distilled water.

Anyone tried anything like this?
Click to expand...

You're gonna end up with some gross and/or painful stuff to put up your nose.

Typically you'd need something pretty water-soluble to attempt a nasal spray; that's why most nasal sprays are salts.
 
nostrum420 said:
You're gonna end up with some gross and/or painful stuff to put up your nose.

Typically you'd need something pretty water-soluble to attempt a nasal spray; that's why most nasal sprays are salts.
Click to expand...
does sound interesting though-eh?
 
BrainWavez said:
Hi! Does anyone have experience with Neurosteroids? Like DHEA, Pregnenolone Allopregnenolone,…?

I found a study Invalid Link Removed with intranasal pregnenolone and was going to try to make a nasal spray. They are using a proprietary gel.

I’m not sure how to dissolve it. I’m thinking ethanol and then distilled water.

Anyone tried anything like this?
Click to expand...
You can find a lot of general info and discussion on dhea and pregnenolone by using those words and Dermacrine in the search function. Of topical and oral use.
 
I found some information:

It’s solubility

doi:10.1002/jps.3030400117

Invalid Link Removed

soluble in ethyl alcohol at 19mg/ml


0.019 gram per cc ethanol
0.081 gram per cc benzyl alcohol


This study they dissolve it in sodium dodecyl sulfate, but then add it with peanut oil for injection.

Invalid Link Removed

0.2% sodium dodecyl sulfate (SDS)


Pregnenolone (Preg) (Sigma-Aldrich) was dissolved in a minimal volume of 0.5% SDS and resuspended in peanut oil. The vehicle solution was a minimal amount of 0.5% SDS in peanut oil. All injections were performed with a 5 ml/kg injection volume.
 
I found some information:

It’s solubility

doi:10.1002/jps.3030400117

Invalid Link Removed

soluble in ethyl alcohol at 19mg/ml


0.019 gram per cc ethanol
0.081 gram per cc benzyl alcohol


This study they dissolve it in sodium dodecyl sulfate, but then add it with peanut oil for injection.


Invalid Link Removed

0.2% sodium dodecyl sulfate (SDS)


Pregnenolone (Preg) (Sigma-Aldrich) was dissolved in a minimal volume of 0.5% SDS and resuspended in peanut oil. The vehicle solution was a minimal amount of 0.5% SDS in peanut oil. All injections were performed with a 5 ml/kg injection volume.
 
I found this:

Invalid Link Removed

Doesn’t seem like it is for sale.

Ingredients: Sterile Saline, BA, Pregnenolone Powder.

What do you think “BA” is?
Bacteriostatic water?
 
In this study Invalid Link Removed

It shows it targets the brain directly on the same side as nostril applied.

I’m thinking I can use a smaller amount, than other routes of administration, and get rapid results.
 
BrainWavez said:
In this study Invalid Link Removed

It shows it targets the brain directly on the same side as nostril applied.

I’m thinking I can use a smaller amount, than other routes of administration, and get rapid results.
Click to expand...
On same side as nostril applied? Didn't undesrstand.. ?

Oral administration should give rapid effects too. And topical needs smaller amount (than oral). And plenty of oral and topical preg readily available, that's just why I'm asking.
 
KvanH said:
On same side as nostril applied? Didn't undesrstand.. ?

Oral administration should give rapid effects too. And topical needs smaller amount (than oral). And plenty of oral and topical preg readily available, that's just why I'm asking.
Click to expand...
i highly suggest applying neuro P5 [topical preg] directly to forehead/temple area. :)

MERRY CHRISTMAS
 
In the study it is applied to one nostril and shown to only reach the side of the brain 🧠 it is applied. It doesn’t have to travel through the entire body/systemically.
 
BrainWavez said:
In the study it is applied to one nostril and shown to only reach the side of the brain 🧠 it is applied. It doesn’t have to travel through the entire body/systemically.
Click to expand...
Hmm, that's interesting. Maybe there are receptors on both sides, but does it matter where they are activated? 🤷‍♂️ I dunno, just spit balling. And too lazy to read the study right now. I only know about the left and right side of the brain having different properties, like logical/analytical thinking (left) vs creative/'artistic' (right). Don't know how inserting preg to only one side of the brain will affect. If that indeed is what's happening with nasal application and if it's even possible.
 
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BrainWavez said:
In the study it is applied to one nostril and shown to only reach the side of the brain 🧠 it is applied. It doesn’t have to travel through the entire body/systemically.
Click to expand...
back in the day i had access to pure mescaline before it had been cut and capped...the amount needed was very small, many times in snorted it up 1 nostril and it worked magnificently....of course that was a different lifetime. 😇
 
I read that study and wondered the same thing, why one nostril? It seems they were measuring the amount of Preg in the brain after administering it via one nostril, and found higher amounts in the same side of the brain as the side of nostril used when administering the spray, and that proved that the nasal administration was effective in getting Preg into the brain... I think they compared it to other methods of administration like IV, which resulted in higher amounts of Preg in both sides of the brain... That's my guess anyway...
BrainWavez said:
In the study it is applied to one nostril and shown to only reach the side of the brain 🧠
Click to expand...
 
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