Natural PPAR modulators
- Thread starter jp_x_type
- Start date
jp_x_type
Member
I have a tub of tta lying around but necer got to try it read as the sides i read about kinda put me off so thats why i was looking into more natural alternatives.
I found out about sea buckthorn and omega 7 (i have a bottle of swanson provinal 450 mg and eclectic institute seabuckthorn whole plant powder) but would like to know what people here think of this or any other alternatives to tta and gw501516, preferably those with first hand experience. Cheers
I found out about sea buckthorn and omega 7 (i have a bottle of swanson provinal 450 mg and eclectic institute seabuckthorn whole plant powder) but would like to know what people here think of this or any other alternatives to tta and gw501516, preferably those with first hand experience. Cheers
jp_x_type
Member
Just found this on bitter melon herb
Source:
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Activating effect of momordin, extract of bitter melon (Momordica Charantia L.), on the promoter of human PPARdelta.
Abstract
AIM:
Bitter melon (Momordica charantia L.) is a common vegetable grown in Okinawa that has also been used recently in medicine for the treatment of diseases such as diabetes, hypertension, and dyslipidemia. Among Bitter melon extracts compounds, we focused on an extract known as momordin in the present study, to examine its effect on peroxisome-proliferator activated-receptor (PPAR) delta (also called PPARdelta in rodents) expression and promoter activity of the human PPARdelta gene.
METHODS:
A human PPARdelta promoter-reporter plasmid was made as a template from a BAC CLONE (RPCI-11C) containing a -3076 bp (BglI site) +74 bp (EcoRI site) sequence. Luciferase assay of PPARdelta promoter activity was performed using HepG2 cells.
RESULTS:
10 and 25 nM Momordin significantly increased the expression of PPARdelta mRNA 1.5-fold (relative to the control). Moreover, 10 and 25 nM Momordin significantly increased PPARdelta promoter activity in a dose-dependent manner, reaching more than 1.5-fold relative to the control.
CONCLUSION:
Our present data obtained through successful cloning of the PPARdelta promoter demonstrate that PPARdelta production and activation are upregulated through PPARdelta promoter activity following momordin treatment.
Source:
Invalid Link Removed
Activating effect of momordin, extract of bitter melon (Momordica Charantia L.), on the promoter of human PPARdelta.
Abstract
AIM:
Bitter melon (Momordica charantia L.) is a common vegetable grown in Okinawa that has also been used recently in medicine for the treatment of diseases such as diabetes, hypertension, and dyslipidemia. Among Bitter melon extracts compounds, we focused on an extract known as momordin in the present study, to examine its effect on peroxisome-proliferator activated-receptor (PPAR) delta (also called PPARdelta in rodents) expression and promoter activity of the human PPARdelta gene.
METHODS:
A human PPARdelta promoter-reporter plasmid was made as a template from a BAC CLONE (RPCI-11C) containing a -3076 bp (BglI site) +74 bp (EcoRI site) sequence. Luciferase assay of PPARdelta promoter activity was performed using HepG2 cells.
RESULTS:
10 and 25 nM Momordin significantly increased the expression of PPARdelta mRNA 1.5-fold (relative to the control). Moreover, 10 and 25 nM Momordin significantly increased PPARdelta promoter activity in a dose-dependent manner, reaching more than 1.5-fold relative to the control.
CONCLUSION:
Our present data obtained through successful cloning of the PPARdelta promoter demonstrate that PPARdelta production and activation are upregulated through PPARdelta promoter activity following momordin treatment.
aaronuconn
Well-known member
TTA, Berberine, Abieta