Silverwolf
New member
I've been fascinated by bioperine (black pepper extract aka piperine) lately and it's ability to improve half-life, absorption, and effectiveness of many supplements I take. How this works is similar to naringenin, the anti-oxidant found in grapefruit, it inhibits CYP3A4 and other cytochrome P450 enzymes. These enzymes are often important for drug metabolism.
Looking into Nolvadex I read that, "It is metabolized in the liver by the cytochrome P450 isoform CYP2D6 and CYP3A4 into active metabolites such as 4-hydroxytamoxifen and N-desmethyl-4-hydroxytamoxifen (endoxifen)[23] which have 30-100 times more affinity with the estrogen receptor than tamoxifen itself. These active metabolites compete with estrogen in the body for binding to the estrogen receptor."
Bottom line, I believe that these supplements could improve the bio-availability of Nolvadex and other substances essentially requiring less to get the same desired effect
Application - To what extent, I'm uncertain, it could be DANGEROUS to mess around with something that we aren't clear as to how far it would affect us but CYP3A4 inhibitors have a much much broader potential for use than I once thought. Again I don't want anyone to kill themselves by a freak drug interaction.
Search "RPM on cycle??" and more importantly "Naringenin and some of its useful pharmakinetics"
I found something similar on these threads ^ but I need 20 posts to link
Of course this is all theory and I really don't know much about the human body. It's all very interesting to me, what do you guys think?
Looking into Nolvadex I read that, "It is metabolized in the liver by the cytochrome P450 isoform CYP2D6 and CYP3A4 into active metabolites such as 4-hydroxytamoxifen and N-desmethyl-4-hydroxytamoxifen (endoxifen)[23] which have 30-100 times more affinity with the estrogen receptor than tamoxifen itself. These active metabolites compete with estrogen in the body for binding to the estrogen receptor."
Bottom line, I believe that these supplements could improve the bio-availability of Nolvadex and other substances essentially requiring less to get the same desired effect
Application - To what extent, I'm uncertain, it could be DANGEROUS to mess around with something that we aren't clear as to how far it would affect us but CYP3A4 inhibitors have a much much broader potential for use than I once thought. Again I don't want anyone to kill themselves by a freak drug interaction.
Search "RPM on cycle??" and more importantly "Naringenin and some of its useful pharmakinetics"
I found something similar on these threads ^ but I need 20 posts to link
Of course this is all theory and I really don't know much about the human body. It's all very interesting to me, what do you guys think?
