I have noticed in the past when taking l dopa that I always experience a headache when I wake up the next morning and I can't get it to go away without a tylenol/ibuprofen/caffeine combo. Significant enough that I would want to stay away. Although I am very interested in the positive effects of L dopa. Any idea why I was suffering and would prolactrone work better for me? After reading through I have noticed I have never taken l dopa without b6 included, could that be why? I don't get headaches during the day just the morning after my dose when I wake. Weird.