legalgear.com said:
How much interest is there in a HydroxyTest Undecanoate lymphatic? I might be able to get 7 or 8 20ml vials for testing purposes. Anyone interested? I sure as hell am! HydroxyTest is an awesome compound IMHO, but that is just me. I really want methyl-hydroxytest...but we can always dream!
EDog
PS Curt, quit hijacking our thread!
Check out the list of studies on undecanoate esters and absorbtion in the ONE+ article at mind and muscle.com.
Absorbtion max 8% with a fatty meal. Other studies showed identical absorbtion with the base powder.
Testosterone Undecanoate (Ester)
T = Testosterone, no ester
TU = Testosterone undecanoate
100mg TU contains 63mg of testosterone.
Study 1:
Females were given 25mg T or 40mg TU dissolved inh oil. No mention of food. Bioavailability of T was found to be 3.66% vs. 6.83% for TU -- an increase of a mere 3% -- and peak levels were almost identical (28).
Study 2:
Hypogonadal (low testosterone levels)males were given 63mg of T or 100mg of TU or 100mg of TU with arachis oil. TU, with or without oil, achieved testosterone levels of 450ng/ml vs. 300 ng/ml -- a difference of only 50% -- no mention of whether it was taken with a meal or not.(29)
It should be noted, in regards to both of the above studies, that testosterone slearance from the blood is higher in eugonadal males (our target audience) than in hypogonadal males or females (30, 31) -- 675 l/day for hypogonadal vs. 1288 l/day for eugonadal, and dose corrected values indicate an area under curve that is 4-fold lower in men than women, following testosterone administration (29,32).
Study 3:
Eugondal (normal testosterone levels) males received 100mg of TU w/oil which resulted in testosterone levels of 6.4ng/ml, up from a baseline of 4.5ng/ml. Given the pharmacokinetics of TU, this would be equivalent to about 3-4% bioavailability -- no better than that of free testosterone (34).
Study 4:
Eugonadal males were given 63mg T or 100mg TU or 100mg TU dissolved in arachis oil with breakfast or without (32). T showed an increase of 12.5nm/l w/breakfast and 10nm/l without -- this represented a 40% higher area under curve than baseline. TU showed an increase of about 6-7nm/l w/meal and only 1nm/l without. It was actually LOWER than T!!! TU w/oil, on the other hand, increased by 25nm/l with a meal, and 11nm/l without. This is a decent study for the ethergels (4-6% bioavailability for TU vs. 2-3% for T), but very damning for the powder ether products. It should also be noted that the meal was 474kcal, 59% of which was fat -- this equals 31 grams of fat!! And, we have discussed the importance of fat for absorption.
Study 5:
Eugonadal males received 129mg TU w/oil which resulted in an increase in testosterone from 200pmol/l to 500pmol/l, with significant elevation for 6 hours. Given the 4 doses needed to keep levels elavated for 24 hours, one would need about 500mg per day. Given 5-10 mg per day needed to produce a eugonadal state and that 129mg of TU is equal to 81mg of testosterone, we get a bioavailability of 4-8%. Also, this was given with breakfast -- it does not say what kind, but one would assume it was the "standard" 31 grams of fat breakfast (35)