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M5/Methly Jacked & Finasteride

Josey Wales

New member
Sorry if the the answer to this is obvious to some, but would it be a waste to take Finasteride with M5 and/or M-Jack? Would they simply work against, or cancel, each other out? I know one substance converts to DHT and the other inhibits DHT conversion (or something like that). However, the thought occured to me that perhaps the M5/MJ conversion process would occur in such a manner to allow them to work together. Anybody have any thoughts on this?

If finasteride is useless, do you think topicals like Minox 15%, Nizora 2% or spiro would, alone, be strong enough to stop major damage from a 3wk M5/MJ cycle? Thanks.
 
finasteride inhibits the 5AR enzyme which converts test to DHT. Because the MDHT is already DHT, finasteride won't do anything to it. The topicals I would think would work, although I don't have any experience.
 
Odessa14 said:
What dose of MDHT are you using?
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I'm not using it yet, but really want to toss it in at the end of a cycle. From what I've read it seems you need between 60mg and 100mg a day to derive significant benefit from M5. True? I was thinking of taking it 4x a day (20/20/40(pwo)/20), spacing the doses roughly 4 hours apart. What's your take on that?
 
I recently started MDHT and have run M5aa before and I am taking finasteride, so I asked my dermatologist a very similar question and he told me that just having that DHT in your system should not affect your hair at all. What makes you lose your hair is the conversion of test to DHT at your scalp, and finasteride prevents this conversion so the M5aa might not have as high of a conversion rate as normal, but the MDHT should be unaffectedsince it is already DHTand needs no converison. And MDHT shouldn't affect your hair loss at all, M5aa will a little. Oh and I got a great effect from M5aa at 40-60mg, and I weighed 205 when I was taking it.

Hope this helps and if I am wrong about something, please feel free to correct me, this is just what my doctor told me, and my girlfriend agreed as well. She has a PhD in Pharmacy.

-WannaGro
 
On the bump, let me know what you'd like to know about and I'll try to get it to you as soon as possible, I only check the boards every couple of days but I have email notification on and check my email every few hours. So let me know what questions you have and I'll try to get them answered.

Later
-WannaGro
 
Looking more into the topicals....just for the fact that I am wary of using Finasteride with MDHT....I wouldnt want to risk impaired gains....

BUT....I am interested in the topicals.....i hope they'll combat any shedding caused by the MDHT....

O14
 
MDHT should not cause shedding because it is already in DHT form and does not undergo 5 alpha reduction at your scalp or prostate, however M5aa will. And Finasteride also should not effect MDHT, since it stops the 5 alpha reduction it will decrease the amount of circulating natural DHT, but will do nothing to DHT already in your system. Oh and my girlfriends phamacology desk reference manual says that finasteride takes 3-6 months to take full effect, but only 14 days after you quit to completely loose effect and return DHT levels to normal. So if you just started taking it a week or two ago just stop and wait until your cycles over if you are really scared of MDHT losing its effect. But if you've been taking the finasteride for a few months I would stay on it.

As I said earlier if anyone finds that I made an error in what I've stated above please let me know or correct me, because all of this is to the best of the people around me and my knowledge. If you still want more info let me know.

-WannaGro
 
i am currently applying azelaic acid 1 or 2 times/day just as a preventive measure on my potentially very "sheddy" cycle. i dont have MPB concerns but i am an avid exerciser of caution. blocking DHT at the scalp - the ONE place where i dont want it? perfect. plus it isnt systemic, as i've read that finasteride CAN reduce circulating DHT, but only through the one pathway (5ar?) the other is unaffected. plus azelaic acid is cheap and you need VERY little.

warning - it burns a little, some applications more than others.
 
WannaGro said:
MDHT should not cause shedding because it is already in DHT form and does not undergo 5 alpha reduction at your scalp or prostate, however M5aa will. And Finasteride also should not effect MDHT, since it stops the 5 alpha reduction it will decrease the amount of circulating natural DHT, but will do nothing to DHT already in your system. Oh and my girlfriends phamacology desk reference manual says that finasteride takes 3-6 months to take full effect, but only 14 days after you quit to completely loose effect and return DHT levels to normal. So if you just started taking it a week or two ago just stop and wait until your cycles over if you are really scared of MDHT losing its effect. But if you've been taking the finasteride for a few months I would stay on it.

As I said earlier if anyone finds that I made an error in what I've stated above please let me know or correct me, because all of this is to the best of the people around me and my knowledge. If you still want more info let me know.

-WannaGro
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WannaGro - Thanks for taking the time to answer, however I find some of the info a bit sketchy......MANY people I have talked to who used MDHT have seen a moderate-to-large increase in shedding.....

Besides that, I can not understand how, just because it is converted, it cannot cause hairloss. I am not challenging you, I just don't understand how you came to that conclusion.

O14
 
not_thebrakes said:
i am currently applying azelaic acid 1 or 2 times/day just as a preventive measure on my potentially very "sheddy" cycle. i dont have MPB concerns but i am an avid exerciser of caution. blocking DHT at the scalp - the ONE place where i dont want it? perfect. plus it isnt systemic, as i've read that finasteride CAN reduce circulating DHT, but only through the one pathway (5ar?) the other is unaffected. plus azelaic acid is cheap and you need VERY little.

warning - it burns a little, some applications more than others.
Click to expand...
Thanks...I'm looking to use some azelaic acid in conjunction with spiro....
 
As far as the hairloss with MDHT goes, I am extremely prone to MPB and I've cycled M5aa which caused me to shed like hell at 40mg/day, and currently I am cycling MDHT and I am up to 100mg/day and I am barely shedding. I know I said that I am taing finasteride, but I just started and it is supposed to take 3-6 months to start working. Also what causes your hair to fall out is the 5 alpha reduction of testosterone at the scalp, which is the conversion of testosterone to DHT. This is what finasteride prevents. And since MDHT is already an active form of DHT it needs no conversion and therefore should not cause hairloss.

-WannaGro
 
WannaGro said:
As far as the hairloss with MDHT goes, I am extremely prone to MPB and I've cycled M5aa which caused me to shed like hell at 40mg/day, and currently I am cycling MDHT and I am up to 100mg/day and I am barely shedding. I know I said that I am taing finasteride, but I just started and it is supposed to take 3-6 months to start working. Also what causes your hair to fall out is the 5 alpha reduction of testosterone at the scalp, which is the conversion of testosterone to DHT. This is what finasteride prevents. And since MDHT is already an active form of DHT it needs no conversion and therefore should not cause hairloss.

-WannaGro
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This is news to me.....thanks WannaGro....I appreciate your help and input....looks like I'm nixing the M5 for some MDHT!Invalid Link Removed


O14
 
No problem I hope you like it, I am really enjoying the strength gain while cutting, since I am in a cutting cycle and I generally lose strength when dieting.

Good luck
-WannaGro
 
WannaGro said:
No problem I hope you like it, I am really enjoying the strength gain while cutting, since I am in a cutting cycle and I generally lose strength when dieting.

Good luck
-WannaGro
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Thanks bro...Good luck to you as well....looking at your sig, it seems you have a good goal set for yourself! Keep me updated on your cycle!Invalid Link Removed


O14
 
As an aside, how long after starting DHT derivatives does shedding typically start? Is it nearly immediate, or does much later? Perhaps it happens both ways depending on the people?
 
Another FYI for the thread, My doc said that finasteride in 1mg. doses only blocks DHT at the skin surface (hair follicles) and does not effect actual hormone levels much. So it may not inhibit the actual gains of M5aa.

However, there have been studies that show decreased sex drive for some men when taking finasteride alone which contradicts what my doc says.

My Conclusion based on my highly educated doc and the clinically proven studies contradicting each other is that nobody knows what the hell they are talking about.
 
MF210 said:
My Conclusion based on my highly educated doc and the clinically proven studies contradicting each other is that nobody knows what the hell they are talking about.
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Invalid Link RemovedInvalid Link Removed I concur....
 
In all seriousness.....Thanks to everyone who helped in this thread....esp WannaGro...wanted to get this stuff down before I lose it all.....
 
Glad I could help O14 and I would have to say that as far as what MF210 said it is impossible to say that one drug has the exact same effect on everyone who takes it. All drugs have the possibility of someone being very sensitive to it or even allergic to it. So thats why the pharmacy gives you that little sheet of drug info when you pick up your prescription. Propecia actually has very few side effects like I think its less than 1% of the people who take it get sides and after a few months generally only .3% of the initial 1% still have these sides. (I think these are the correct numbers but I could be wrong because I don't have the sheet in front of me.)

And thanks O14 and I finish my current cycle in 2 1/2 weeks, and it was a big 8 week total recomp to get ready for the warm weather and clean up the mess from winter. Right now I am actually 194 and about 9 1/2 - 10% BF and I have a little more cutting to do and then right before summer I'll go for broke with a very dry 4 week bulker.

-WannaGro
 
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