LakeMountD said:
With the half life though it doesn't really matter if you get some downregulation, it is in your blood for quit a long ass time, which is why the two a day injections will be sufficient for attaching to the receptors.
Yes, that long half-life. Look, it might
inherently have a long half-life but that doesn't mean that the IGF-1 will not be finding receptors in the meantime. IOW yes it does resist IGFBP binding, but not receptor binding. So while it may very well
theoretically stay in your blood for a long time, it
only does so for as long as it doesn't find a receptor to bind to. Who's going to argue about that?
Now how can you be so very sure that the levels stay elevated in the bloodstream for long? You can't. You cannot know how long it takes for IGF-1 to find receptors. There's no way to know that, unless you have done studies on bodybuilders and there is no such study.
Moreover, if the blood levels are elevated for any significant amount of time, it means you are overdosing and wasting product. Why? Well longer-duration elevated blood levels means that most receptors are taken up. This in turn means that receptors in just about every tissue of the body are activated through Long R3 IGF-1 (or natural paracrine IGF-1) binding.
Are we looking to grow muscle or internal organs, hair, nails and tumors here? Are we trying to be efficient or just whack as hard as we can on our bodies for general, unspecified "lean body mass"? I'm all about the former. For those who prefer the latter, of course, go ahead, inject twice a day.
LakeMountD said:
Plus there is no scientific evidence that rapid downregulation occurs. To top that off even if it did occur we do not know if it will still be able to get its job done even with half receptors. The one study I have on it showed a 50% drop in receptors in the small intestine of like a pig or something with exogenous recombinant IGF-1 (at SUPER high dosages, we are talking like 600mcg per kg bodyweight), but at the same time showed a double in plasma IGF-1 levels. So you figure if this is the case with LR3 IGF-1 then it shouldn't matter too much about receptors since LR3 lasts longer in the blood than rIGF-1.
Here I am not talking about longer-term IGF-1 receptor downregulation from constant activation through IGF-1 injections. I am talking about the
transient IGF-1 receptor upregulation from heavy resistance exercise. It is transient and short-lived. There is ample evidence of that. I believe it lasts only 20 minutes or so, from the last studies I read about it about 5-10 years ago. I'm not finding them in PubMed, but that should be easy for you to verify this fact.
So... YES you will get muscle growth from twice a day injections. Yes you will keep blood levels up this way. My argument isn't with that. My argument is that we do not WANT to keep blood levels up all day. My argument is that we want
ONLY muscle and other workout-damaged tissue growth. My argument is that we should inject IGF-1 in such a way as to maximize
myoblast hyperplasia. Other benefits of IGF-1 can be obtained in other ways than with IGF-1 and being so expensive, it should be targeted to do what it's good at, and that's myoblast hyperplasia.