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LGD-2226

UncleSarm

UncleSarm

Well-known member
Anyone know anything more about LGD-2226?

This is the abstract: Invalid Link Removed
And this is the full document: Invalid Link Removed

"Muscle weight from thesetreated animals increased dramatically in response toLGD2226 "
 
"In vitro, the potency of LGD-2226 was similar to that of DHT in an androgen-responsive luciferase reporter assay. In prostate cancer cells, LGD-2226 showed weak partial agonism in activation of the prostate-specific antigen (PSA) promoter [185]. LGD-2226 is reportedly in phase I clinical development [28], but a recent publication suggests that the development of this compound has been abandoned because of preclinical toxicity issues [29]."

Unfortunately I don't have a reference for it. Bold and coloring are added by me.
 
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