Is IBUPROFEN ok to take on cycle?
- Thread starter JoePaul39
- Start date
Steeleydan
Member
Another vote here for: Yes you should be fine.
ChocolateClen
Well-known member
Ibp is one of the few things absorbed in the stomach, the liver doesn’t really have to do much to it. You’d be good to go as long as you don’t take too much. Gotta watch the Bp and other stuff if you take a bunch but a few won’t hurt
2kvette
Active member
No, increased bleeding risk. Oral androgens are anticoagulents. NSAIDs are anticoagulants. GI bleeding, heartburn, etc.
most people think that those nose bleeds everyone gets on cycle are from high BP, They're not. It's from the coagulation blockade from 17-a-methyls.
Matthersby
Well-known member
Stick with IBU and my favorite: Aspirin if you use steroids OR lift weights. Tylenol is garbage, doesn’t help with pain nearly as well as NSAIDS and is unnecessarily straining on the liver.
That’s why when people want to kill themselves they just take 50 of em. But then they realize their death will be the most miserable 4 days of liver failure ever.
That’s why when people want to kill themselves they just take 50 of em. But then they realize their death will be the most miserable 4 days of liver failure ever.
stimtron
Member
Don't do it. It will HINDER your muscle recovery process and put you at higher risk of heart attacks and strokes (which is already raised by your steroid use).
Instead take palmitoylethanolamide it's a Potent anti inflammatory and also a pain killer that works on your endocannabinoid system. 1.8 grams is easily as strong as 3 grams of aspirin.
Chados
Well-known member
What you want to be careful with is paracetamol but this liverdamage is exaggerated.
Example, a dosage of anavar might be recommended for a bodybuilder at 50mg but any healthy liver can easily go 100mg or more. A recommended dosage of paracetamol i believe is 4000mg a day and this is a far more damaging compound to the liver. Not sure what the absolute max dosage would be as they would never the exact max as that would kill some people but taking twice as much would kill you while taking twice as much steroids wouldn't.
It's really hard to combine two liver toxic compounds and assume how much damage they do together at that dosage but I have absolutely no doubts you could mix them at a low dosage. Ibuprofen is not even close to as dangerous as paracetamol.
Example, a dosage of anavar might be recommended for a bodybuilder at 50mg but any healthy liver can easily go 100mg or more. A recommended dosage of paracetamol i believe is 4000mg a day and this is a far more damaging compound to the liver. Not sure what the absolute max dosage would be as they would never the exact max as that would kill some people but taking twice as much would kill you while taking twice as much steroids wouldn't.
It's really hard to combine two liver toxic compounds and assume how much damage they do together at that dosage but I have absolutely no doubts you could mix them at a low dosage. Ibuprofen is not even close to as dangerous as paracetamol.
stimtron
Member
Invalid Link Removed
Invalid Link Removed 2018 Feb;222(2). doi: 10.1111/apha.12948. Epub 2017 Sep 16.
High doses of anti-inflammatory drugs compromise muscle strength and hypertrophic adaptations to resistance training in young adults.
CONCLUSION:
Maximal over-the-counter doses of ibuprofen attenuate strength and muscle hypertrophic adaptations to 8 weeks of resistance training in young adults. Thus, young individuals using resistance training to maximize muscle growth or strength should avoid excessive intake of anti-inflammatory drugs.
Invalid Link Removed 2018 Feb;222(2). doi: 10.1111/apha.12948. Epub 2017 Sep 16.
High doses of anti-inflammatory drugs compromise muscle strength and hypertrophic adaptations to resistance training in young adults.
CONCLUSION:
Maximal over-the-counter doses of ibuprofen attenuate strength and muscle hypertrophic adaptations to 8 weeks of resistance training in young adults. Thus, young individuals using resistance training to maximize muscle growth or strength should avoid excessive intake of anti-inflammatory drugs.
Matthersby
Well-known member
This study is quoted and cited a lot. And while for someone really dedicated to weightlifting, training naturally, may see some of their recovery hindered - it doesn’t make a damn bit of difference for the steroid enhanced athlete.
stimtron
Member
Why would anyone take anything that hinders muscle growth and recovery when their purpose is the opposite? Plenty of anti inflammatories that don't have those muscle side effects.
Old Witch
Well-known member
They are actually one of the best out there. I just don’t like saying it publicly, because of the whole “poof-gone” effect AM has.
Ask @Matthersby about their Cialis and how strong it is.
JoePaul39
Well-known member
Lol I highly doubt using Ibuprofen for 4 or 5 days will result in either a heart attack or a stroke, nor impede gains when I am on a
strong dosed steroid, a prohormone, and three Sarms.
stimtron
Member
Based on what? It's proven ibu inhibits muscle strength and hypertrophic changes during training. Why take anything that research show counters muscle strength and hypertropic changes when your goal is the opposite? Other anti inflammatories won't have that effect so do you have any logical reason to avoid better alternatives?
If you have goal you should avoid anything that opposes your goals. Pretty basic...
Here's another study.
Invalid Link Removed 2018 Feb;222(2). doi: 10.1111/apha.12990. Epub 2017 Nov 30.
Non-steroidal anti-inflammatory drugs may blunt more than pain.
Theoretically, reducing prostanoid-induced inflammation via NSAID administration leads to an alleviation of post-exercise pain and edema, although it remains equivocal whether blocking these enzymes actually promotes a therapeutic effect in practice 3 .
Regardless, the findings clearly indicate that the COX pathway and its associated synthesis of prostaglandins plays an important role in the hypertrophic response to resistance training. Moreover, the study provides compelling evidence that athletes concerned with maximizing muscular adaptations should limit consumption of ibuprofen, keeping both the dose and frequency of usage low.
It could therefore be inferred that NSAID administration, while perhaps not impacting acute measures of MPS, would be deleterious to long-term muscle growth by interfering with the ability for muscle tissue to expand its synthesis of proteins needed for repair and remodeling over time.
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Matthersby
Well-known member
I’ve read the study.
And I’m not sold.
I take 5 aspirin a day and I’ve gained 38 lbs since January. My gf literally is telling me to stop gaining so much weight and I keep telling her “I’m trying! I keep taking Aspirin! And it won’t work!”
You’re a really smart guy and I can tell you read that study really well so it’s nothing against you.
But the study is stupid. And doesn’t matter.
Matthersby
Well-known member
I also jack off before training, Drink tons of soy milk, and eat Kratom every day while watching Oprah, on antidepressants. Yet the muscles keep coming.
Matthersby
Well-known member
I also jack off before training, Drink tons of soy milk, and eat Kratom every day while watching Oprah, on antidepressants. Yet the muscles keep coming.
stimtron
Member
Study was on ibuprofen not aspirin not sure if aspirin lowers IL-6 levels which ibuprofen did (not sure why anyone would want low IL-6 if you're aimming for muscle growth it's not too dissimilar from some drug lowering your HGH or T levels in terms of hinder a factor in muscle growth and recovery) so can't comment on it. It's not my study so I welcome any constructive comments. Science is a process.
What aspects of the study do you feel was stupid?
Matthersby
Well-known member
Cheers for putting up with my shitty trolling comments. I wasn’t really trying to be a dick. I’m still undecided on the study, but I swear, aspirin saves my life, I’m so unhealthy that I take it mostly out of fear until my next lab draw. IBU I haven’t taken long term enough to see any difference in hypertophy or anything.
AnabolicGuru
Well-known member
Yup, this. I was actually using ibuprofen while on nanodrol about 2 years ago because I was dealing with severe neck pain. It wasn’t worth it though; I had developed gastritis (confirmed via EGD) and honestly, the ibuprofen didn’t help much with the pain anyways. I only use ibuprofen now if I have a headache, which is extremely rare.
JoePaul39
Well-known member
I’m mainly using it to help with the inflammation of the hamstring to speed the healing process. A couple dr. articles I read online said it can do this since it is an anti inflammatory . I want it to heal as quickly as possible so I can exercise it again.
Chados
Well-known member
Aspirin is such a good compound, it's regarded as one of the most effective things to survive which is kinda what we take for granted.
Hyde
Legend
Why are you chronically taking so much aspirin? I feel like this needs to be addressed. If it’s stroke prevention then a baby aspirin and a solid dose of nattokinase & vit K2 is what you should be looking at.
Matthersby
Well-known member
For as reckless as I am, I’m kind of a hypochondriac, especially when it comes to clots, strokes, and heart attacks. I have bad genetics for clots, and I haven’t had labs since last August. I’ll research your combo. I’ve thought about doing baby aspirin instead for sure...
Hyde
Legend
Get bloods! A female hormone panel (including a full CMP) + lipids is $87 with the monthly 15% off code on privatemdlabs. If your hematocrit is high (provided you are properly hydrated before the fasted blood draw), give blood and get on grapefruit seed extract to get it in range.
But nattokinase will thin your blood, while k2 will allow it to selectively clot when needed while helping deter atherosclerosis. All anabolic users should be getting 180mcg of K2 daily, year round.
Matthersby
Well-known member
Thanks bro. I’ve got a new primary that took 2 months to get into but I stress a lot. I’ve never even had really bad labs anyways but clots scare the **** outta me. If you’d seen people in the ER drop dead like I have, you’d feel the same exact way about clots.
Hyde
Legend
No, I understand - nothing scarier than being “fine” one minute then just tapping out unexpectedly. I have heard tons of horror stories.
Nattokinase, K2, baby aspirin. And making sure things like lipids are under control with sensible oral use, diet containing enough fiber, & taking krill or high potency fish oil and citrus bergamot. Things like pomegranate extract, pycnogenol, D3, & ubiquinol may help as well, but the initial 3 are biggies.
Matthersby
Well-known member
I appreciate you brother.