Insulin Safety

Trento

New member
Ok guys, I'm going to bring up one of the less popular anabolics (put on your asbestos vests! :AR15firing:) INSULIN.

From a brief search of the web you can find a number of insulin protocols, the merits of which can be discussed ad nauseum, but I'd like to consider the more long-term dangers than simple hypoglycemia. Insulin treatment in Type 1 diabetics (whose pancreas produce no insulin) has been linked to atherosclerosis, but these individuals are taking much greater quantities of insulin than would be necessary for anabolic purposes.

There is also the concern that prolonged insulin use could supress endogenous insulin production, but from what I've read, that part of the endocrine system recovers much faster than HPTA due to insulin production being only one of the functions of the pancreas. Thus use in a reasonable protocol (4 weeks on, 6 weeks off) seems not to bear too great of a risk.

Insulin resistance, however, has been coming to mind more and more lately. We are all insulin resistant to a certain point, but insulin resistance increases with age as a result of more years of insulin exposure. Insulin resistance leads to Type 2 diabetes, which anyone who enjoys life should try to avoid.

Anyone have any experience with this? Or possibly any literature references (preferred)?

Much thanks in advance.
 
Well, it's insulin administered sans C-peptide. You see, the body metabolizes proinsulin into C-peptide and insulin. According to the latest studies, there was a significant reduction in atherosclerosis risk for those coadministering insulin and C-peptide, but I don't think the timeframe of the study was long enough to be conclusive. Thise study was conducated over < 5 years, and to conclusively link the two together, you'd need a retrospective study searching over several decades. C-peptide isn't normally coadministered with insulin, however, so I gues we'll have to wait until findings warrant further research. :(
 
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