Injectable carnitine vs oral

Stanfoo

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Anyone tried both oral and injectable carnitine?

Injectable is better absorption, but does it actually "work better" than oral? Androgen receptor upregulation is the main goal.

Does anyone notice any subjective differences between the two?
 
Oral bioavailability is only like 14%....so you would need to take alot more to get an adequate dosage....

Then there is the TMAO causing cancer research
....u avoid this by injecting it
 
Stanfoo said:
Anyone tried both oral and injectable carnitine?

Injectable is better absorption, but does it actually "work better" than oral? Androgen receptor upregulation is the main goal.

Does anyone notice any subjective differences between the two?
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I took it oral for a few weeks. Now beginning injection. @Leakydelts is positive injection is better.
 
I'm doing injectable right now...it feels like my metabolism is spread up...and makes TRT go further via AR being increased.
 
There’s a great video on the oral bioavailability and why injectable is considerably superior in every way. It was more plates more dates I believe

that being said I haven’t tried injectables
 
This is where I got the info
 
I've only been using 400mg pre workout and noticed great pumps and fat loss...eating around maintenance
 
manifesto said:
I've only been using 400mg pre workout and noticed great pumps and fat loss...eating around maintenance
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If I knew the first thing about non oral cycles I would probably be all over it. I’ve never injected and I’m paranoid about F’ing myself up
 
MFTrainz said:
If I knew the first thing about non oral cycles I would probably be all over it. I’ve never injected and I’m paranoid about F’ing myself up
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Dude, this is super safe.. Just watch a few videos. Get some 29g 1/2" Insulin syringes off of Amazon and do it!
I'm looking to maybe brew my own l carnitine just to save a few bucks.
 
enhanced said:
Dude, this is super safe.. Just watch a few videos. Get some 29g 1/2" Insulin syringes off of Amazon and do it!
I'm looking to maybe brew my own l carnitine just to save a few bucks.
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Dude there’s like a million questions I would have just. I wish I could get a doc to inject me and be like “this is how you do it every time”
 
enhanced said:
Dude, this is super safe.. Just watch a few videos. Get some 29g 1/2" Insulin syringes off of Amazon and do it!
I'm looking to maybe brew my own l carnitine just to save a few bucks.
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Depending on your dose you will save a lot after initial set up. I’m about to brew my first batch and will dose at 1g a day.
 
THOR 70 said:
Depending on your dose you will save a lot after initial set up. I’m about to brew my first batch and will dose at 1g a day.
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You gonna dose 1g indefinitely? Or this part of a cut or something?
 
Another option, to avoid injecting everyday, is to inject 3 times per week, and take caps the other days....you will build saturation faster this way
 
THOR 70 said:
1g for a good long run. Will monitor labs, sides, results for prob 6 months or so then reevaluate.
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Cool man. What labs u gonna monitor? I haven't heard if any negative sides
 
MFTrainz said:
If I knew the first thing about non oral cycles I would probably be all over it. I’ve never injected and I’m paranoid about F’ing myself up
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Injecting Carnitine is a breeze. just draw desired amount in a half inch slin pin. Alcohol swab the side of your glute. Push pin in glute. Inject. No pain. Real hard to mess up. Once you do it once, you'll be like, what was all the fuss about.
 
manifesto said:
I've only been using 400mg pre workout and noticed great pumps and fat loss...eating around maintenance
Click to expand...
Make sure you have simple carbs around that injection. Necessary to drive the carnitine into the muscle. Also, pre workout injection not necessary. The benefits you get from Carnitine will be from it's accumulation) saturation into the muscle, similar to creatine. So, you could take post workout, and get the same effects during your next workout as you would if you injected pre workout.
 
ValiantThor08 said:
Make sure you have simple carbs around that injection. Necessary to drive the carnitine into the muscle. Also, pre workout injection not necessary. The benefits you get from Carnitine will be from it's accumulation) saturation into the muscle, similar to creatine. So, you could take post workout, and get the same effects during your next workout as you would if you injected pre workout.
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True...but my routine is pre workout...so easy to stick to...

Where is the research suggesting carbs are needed?
 
ValiantThor08 said:
Make sure you have simple carbs around that injection. Necessary to drive the carnitine into the muscle. Also, pre workout injection not necessary. The benefits you get from Carnitine will be from it's accumulation) saturation into the muscle, similar to creatine. So, you could take post workout, and get the same effects during your next workout as you would if you injected pre workout.
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True...but my routine is pre workout...so easy to stick to...

Where is the research suggesting carbs are needed?
 
manifesto said:
True...but my routine is pre workout...so easy to stick to...

Where is the research suggesting carbs are needed?
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synthetek.com

[:en]The Science Behind: ‘Synthetine – Lipid (Fat) Transporter’[:] - Synthetek

Synthetine™ is an L-Carnitine based sterile preparation manufactured by a pharmaceutical company in accordance with the highest level of manufacturing practices. Synthetine is a highly bioavailable form of L-Carnitine that if used together with SyntheDextrin will activate a “switch” that will...
synthetek.com

A lot of information in there. From my understanding, carbs are necessary for Carnitine to be pulled into the muscle.
 
manifesto said:
Cool man. What labs u gonna monitor? I haven't heard if any negative sides
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Just full panels to see if I notice any negative/positive changes in hormones, inflammatory markers, lipids, etc.

Question for those on TRT that have done this: If androgen receptor density is increased, is the dose of test just more effectively used, or would you want to increase dose to saturate more more receptors? My gut tells me it’s the first, that test isn’t being fully used due to lack of ARs and normal dose will be maximized.
 
THOR 70 said:
Just full panels to see if I notice any negative/positive changes in hormones, inflammatory markers, lipids, etc.

Question for those on TRT that have done this: If androgen receptor density is increased, is the dose of test just more effectively used, or would you want to increase dose to saturate more more receptors? My gut tells me it’s the first, that test isn’t being fully used due to lack of ARs and normal dose will be maximized.
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The same amount of test will now be more effective. No need to up dose.
 
There have been several anecdotal reports of people using it prior to fasted cardio and seeing increased fat metabolization
 

My Fascination with inj L-Carnitine

I have always been fascinated with this compound, and the more I learn the more fascinated I become. L-CARNITINE like HGH has many fascinating effects on so many things in the human body. For those of you who take massive amounts of AAS claiming that your a "low responder" you really need to so...
www.professionalmuscle.com

a lot of end-user feedback here
 
Darkhorse192 said:

My Fascination with inj L-Carnitine

I have always been fascinated with this compound, and the more I learn the more fascinated I become. L-CARNITINE like HGH has many fascinating effects on so many things in the human body. For those of you who take massive amounts of AAS claiming that your a "low responder" you really need to so...
www.professionalmuscle.com

a lot of end-user feedback here
Click to expand...
professional muscle forum???
 
MFTrainz said:
Dude there’s like a million questions I would have just. I wish I could get a doc to inject me and be like “this is how you do it every time”
Click to expand...

Apprehension is normal but remind yourself that they teach small children how to self admin with insulin pins. With the 1/2 in slin pin short of jamming it into a bone, almost impossible unless being a complete knob, or jamming it in your eye it is almost impossible to screw up with a water based compound like this.

Go get a B12 shot at one of the walk-in lab testing places if you need to see it firsthand but if you can shave without killing yourself I think you will be good to go lol.
 
BCseacow83 said:
Apprehension is normal but remind yourself that they teach small children how to self admin with insulin pins. With the 1/2 in slin pin short of jamming it into a bone, almost impossible unless being a complete knob, or jamming it in your eye it is almost impossible to screw up with a water based compound like this.

Go get a B12 shot at one of the walk-in lab testing places if you need to see it firsthand but if you can shave without killing yourself I think you will be good to go lol.
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So basically with water based compounds it’s much harder to screw yourself than it is with oils?
now if I could only find properly dosed on one of these sites I might be on board for a late summer run
 
ValiantThor08 said:
synthetek.com

[:en]The Science Behind: ‘Synthetine – Lipid (Fat) Transporter’[:] - Synthetek

Synthetine™ is an L-Carnitine based sterile preparation manufactured by a pharmaceutical company in accordance with the highest level of manufacturing practices. Synthetine is a highly bioavailable form of L-Carnitine that if used together with SyntheDextrin will activate a “switch” that will...
synthetek.com

A lot of information in there. From my understanding, carbs are necessary for Carnitine to be pulled into the muscle.
Click to expand...

Insulin is what is necessary. Exogenously applied, or endogenously released from food consumption - especially carbs.
 
Can anyone confirm, do the Synthetek labels mention anything about injecting? Cheers
 
Nac said:
Can anyone confirm, do the Synthetek labels mention anything about injecting? Cheers
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Speaking of, I think I was looking at theirs, isn’t it lower dosage to where you’d have to inject more than once a day?
 
MFTrainz said:
Speaking of, I think I was looking at theirs, isn’t it lower dosage to where you’d have to inject more than once a day?
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They recommend 1ml (200mg) per 25kg of bodyweight...John Meadows loves this stuff, and he thought 2ml (400mg) was totally sufficient for him to see results during contest prep. He is much shorter than me, but carries much more muscle. I guess I'm thinking if 400mg is enough for him itll be plenty for me.

Pretty sure he was pinning all prewo. I'd have to revisit his thread to confirm.
 
If I can successfully brew, use, and verify results/quality, would anyone be willing to purchase? If I can make a couple bucks for my time, save you a bunch of money and provide a better concentration(500mg/ml) over the brand being mentioned. I might be down if I get the process dialed in and feel it’s very high quality.
 
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ValiantThor08 said:
Make sure you have simple carbs around that injection. Necessary to drive the carnitine into the muscle. Also, pre workout injection not necessary. The benefits you get from Carnitine will be from it's accumulation) saturation into the muscle, similar to creatine. So, you could take post workout, and get the same effects during your next workout as you would if you injected pre workout.
Click to expand...

You might be right, prewo dosing is not exactly "necessary", but if taking carbs around the dosing in order to increase or maximize lean tissue uptake then prewo dosing aligns with this goal too (exercise will attenuate nutrient uptake to lean tissue). For pretty much the same reasons it is recommended to dose ArA prewo.

The accumulation effect you allude to is more relevant to oral dosing of l-carnitine, not inj. Injection is much more acute.

Ugh not trying to bust your balls, just been reading a John Meadows thread on this sh1t, plus the Synthetek write up. Some good stuff there.
 
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Hyde said:
Insulin is what is necessary. Exogenously applied, or endogenously released from food consumption - especially carbs.
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That's what I was getting at, but thanks.
 
Nac said:
You might be right, prewo dosing is not exactly "necessary", but if taking carbs around the dosing in order to increase or maximize lean tissue uptake then prewo dosing aligns with this goal too (exercise will attenuate nutrient uptake to lean tissue). For pretty much the same reasons it is recommended to dose ArA prewo.

The accumulation effect you allude to is more relevant to oral dosing of l-carnitine, not inj. Injection is much more acute.

Ugh not trying to bust your balls, just been reading a John Meadows thread on this sh1t, plus the Synthetek write up. Some good stuff there.
Click to expand...
Injection can have a much more acute effect compared to oral, no doubt, but I have read there is still loading involved with injection, but it doesn't take as long as oral. Oral loading takes around 100 days.
 
Nac said:
Can anyone confirm, do the Synthetek labels mention anything about injecting? Cheers
Click to expand...

No they will not say that anywhere on their site or product. Reasons should be obvious. The bottle appears to have a screw off top but you leave that in place and it is a multi-use top.
 
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Some ideas, just to throw out there, that I've been getting from a few older threads at another site...

Benefits appear to increase as dosing increases. Some guys have run this as high as 1gm per day.

Benefits are still very much there at lower doses (200mg).

Most have been dosing around the 400mg mark.

Meadows, as well as others, have reported dosing prewo only on training days still beneficial. Every day dosing is not "necessary" to see effects and benefits.

This all applies to inj.
 
somewhat anectodal but i have taken a cycle of carnitine while back and def noticed some testicular fullness / improved libido.

I started again 2 weeks ago and I am noticing again. Looking at some studies it seems to help with male infertility. We know that libido is somewhat controlled by Sperm production and volume in testis. Perhaps carnitine def does play a role with androgen receptors in testis also. Testosterone is actually protective of sperm motility. Likely carnitine amplifying Testosterone's affects on the sperm via androgen receptor.

www.ncbi.nlm.nih.gov

Effects of L-carnitine and L-acetyl-carnitine on testicular sperm motility and chromatin quality

Background: Sperm cells extracted from testes (TESE) have poor chromatin quality and motility. Various substances are used in the laboratory to increase sperm motility and improve the ART outcomes; however, there are few research which considered improving ...
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

pubmed.ncbi.nlm.nih.gov

Relationships between serum hormone levels and semen quality among men from an infertility clinic - PubMed

Participation rates in epidemiologic studies on semen quality are generally very low, raising concerns as to the potential for selection bias. Since hormones both initiate and maintain spermatogenesis, they may serve as surrogates of semen quality in epidemiologic studies. For this reason, in...
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
 
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My little update...

About 1 week in. No sh1t, this stuff goes in smooth and dissipates quick as fuk (no lumps....I've never used water soln before).

Pumps, not really noticed much additional.

Fat loss, meh too early to tell I think. I have enough for 8 weeks at 3.5ml per day (350mg). A few days I've done cardio sessions twice, I've dosed prior to each. Tried also to have some sort of glucose or carb before dosing, during training, and after.

Edit: sweating. Sweating like a fuker during cardio. Beyond normal.
 
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has anyone looked into liposomal delivery methods? I was given a small ultrasonic cleaner and was considering trying to make some liposomal solutions this summer.
 
Vitruvian Man said:
Bump for all the guys running to give an update 👍
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i'm not running to give a update, but i did just finish a rare [for me] night run...felt good, i need to run at night more often!!!
 
I have all the home brew supplies but have yet to do it. Been crazy busy. Now would
Be ideal for summer shreds tho
 
Been using 400mg injectable carnitine a few times per week...increased vascualroty and fat loss
 
I'm not going to bother with it again. The benefits are too subtle to justify the cost and all the extra pinning.
 
Nac said:
I'm not going to bother with it again. The benefits are too subtle to justify the cost and all the extra pinning.
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Didn’t go back and read but how high were you running it and what is your weight/ bf %?
 
Nac said:
I'm not going to bother with it again. The benefits are too subtle to justify the cost and all the extra pinning.
Click to expand...

I wonder if there are differences in quality among brands or possibly with the number of carbs being taken with because I have heard this similar sentiment from other guys, but conversely, have heard different guys say they got much leaner and were able to stay much leaner while gaining and that it is one of the greatest things they have come across in terms of maintaining a leaner offseason look while gaining...
 
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