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Genistein
Finally, a naturally potent MAOI that works!
What is a MAOI?
MAOI stands for Monoamine oxidase inhibitors, which are a class of drugs used to treat certain mental health conditions such as depression, anxiety, and Parkinson's disease.
Monoamine oxidase is an enzyme that breaks down certain neurotransmitters like serotonin, dopamine, and norepinephrine. MAOIs work by inhibiting the action of this enzyme, leading to increased levels of these neurotransmitters in the brain.
MAOIs were one of the first types of antidepressant medications developed, but they are not commonly used as first-line treatments because of their potential for serious side effects and interactions with other medications and foods. If you are prescribed an MAOI, it is important to follow your doctor's instructions carefully and avoid consuming foods and beverages that contain high levels of tyramine, which can lead to a dangerous increase in blood pressure.
Finally, a naturally potent MAOI arrives in Genistein
Taken from “evaluation of the isoflavone genistein as reversible human monoamine oxidase-a and -b inhibitor”: (1)
Monoamine oxidases inhibitors (maois) are effective therapeutics. As finding safer and reversible maois is our target, we characterized the recombinant human (h) mao-a and mao-b inhibition potentials of two common natural isoflavones, genistein (gst) and daidzein (dz) using luminescence assay. The results obtained showed that dz exhibits partial to no inhibition of the isozymes examined while gst inhibited hmao-b (ic50 of 6.81 μm), and its hmao-a inhibition was more potent than the standard deprenyl. Furthermore, the reversibility, mode of inhibition kinetics, and tyramine oxidation of gst were examined. Gst was a time-independent reversible and competitive hmao-a and hmao-b inhibitor with a lower k i of hmao-b (1.45 μm) than hmao-a (4.31 μm). Gst also inhibited hmao-b tyramine oxidation and hydrogen peroxide production more than hmao-a. Docking studies conducted indicated that the gst reversibility and hmao-b selectivity of inhibition may relate to c5-oh effects on its orientation and its interactions with the threonine 201 residue of the active site. It was concluded from this study that the natural product gst has competitive and reversible maos inhibitions and may be recommended for further investigations as a useful therapeutic agent.
The obtained results indicate that the isoflavone gst has potent hmao-a and hmao-b inhibitory activities compared to its analog dz negligible inhibitory effects. Gst mao-a inhibition potency was more than the standard dep. However, its affinity and potency to inhibit hmao-b were higher than hmao-a. Gst valuable mao inhibitory capacity over dz and selectivity to inhibit mao-b may be due to the presence of c5-oh substitution that may have worked as an inhibitory group. The data obtained clearly show that gst is a reversible and competitive mao-a and mao-b inhibitor and, consequently, can safely decrease hmaos toxic h2o2 byproduct, with the least chance to have the cheese effect incidence. Based on the data obtained in this study we recommend further investigations to examine the use of gst as a possible agent for the therapeutic management of pd patients with depression.
Genistein proved to reverse mao-a inhibition [41], improved cognitive functions in males [59], and exhibited antioxidant and anti-cancer effects [60,61]. In pca cells, genistein protected from aging-related dna damage [62], inhibited epithelial-to-mesenchymal transition [63], and lncap invasiveness [64]
On the other hand, daidzein, which has a structure similar to that of genistein without a hydroxyl group at the c5 position, showed a weak inhibitory effect against both mao isozymes (ic 50 values of 304.05 and 356.87 µm for mao-a and -b, respectively).
The two natural isoflavone analogs gst and dz showed a dramatic difference in their mao inhibitory properties with gst being highly more potent than dz.
Genistein is a potent mao inhibitor which contributes to potentiating all other stimulants found in Oracle and is a true game changer.
Finally, a naturally potent MAOI that works!
What is a MAOI?
MAOI stands for Monoamine oxidase inhibitors, which are a class of drugs used to treat certain mental health conditions such as depression, anxiety, and Parkinson's disease.
Monoamine oxidase is an enzyme that breaks down certain neurotransmitters like serotonin, dopamine, and norepinephrine. MAOIs work by inhibiting the action of this enzyme, leading to increased levels of these neurotransmitters in the brain.
MAOIs were one of the first types of antidepressant medications developed, but they are not commonly used as first-line treatments because of their potential for serious side effects and interactions with other medications and foods. If you are prescribed an MAOI, it is important to follow your doctor's instructions carefully and avoid consuming foods and beverages that contain high levels of tyramine, which can lead to a dangerous increase in blood pressure.
Finally, a naturally potent MAOI arrives in Genistein
Taken from “evaluation of the isoflavone genistein as reversible human monoamine oxidase-a and -b inhibitor”: (1)
Monoamine oxidases inhibitors (maois) are effective therapeutics. As finding safer and reversible maois is our target, we characterized the recombinant human (h) mao-a and mao-b inhibition potentials of two common natural isoflavones, genistein (gst) and daidzein (dz) using luminescence assay. The results obtained showed that dz exhibits partial to no inhibition of the isozymes examined while gst inhibited hmao-b (ic50 of 6.81 μm), and its hmao-a inhibition was more potent than the standard deprenyl. Furthermore, the reversibility, mode of inhibition kinetics, and tyramine oxidation of gst were examined. Gst was a time-independent reversible and competitive hmao-a and hmao-b inhibitor with a lower k i of hmao-b (1.45 μm) than hmao-a (4.31 μm). Gst also inhibited hmao-b tyramine oxidation and hydrogen peroxide production more than hmao-a. Docking studies conducted indicated that the gst reversibility and hmao-b selectivity of inhibition may relate to c5-oh effects on its orientation and its interactions with the threonine 201 residue of the active site. It was concluded from this study that the natural product gst has competitive and reversible maos inhibitions and may be recommended for further investigations as a useful therapeutic agent.
The obtained results indicate that the isoflavone gst has potent hmao-a and hmao-b inhibitory activities compared to its analog dz negligible inhibitory effects. Gst mao-a inhibition potency was more than the standard dep. However, its affinity and potency to inhibit hmao-b were higher than hmao-a. Gst valuable mao inhibitory capacity over dz and selectivity to inhibit mao-b may be due to the presence of c5-oh substitution that may have worked as an inhibitory group. The data obtained clearly show that gst is a reversible and competitive mao-a and mao-b inhibitor and, consequently, can safely decrease hmaos toxic h2o2 byproduct, with the least chance to have the cheese effect incidence. Based on the data obtained in this study we recommend further investigations to examine the use of gst as a possible agent for the therapeutic management of pd patients with depression.
Genistein proved to reverse mao-a inhibition [41], improved cognitive functions in males [59], and exhibited antioxidant and anti-cancer effects [60,61]. In pca cells, genistein protected from aging-related dna damage [62], inhibited epithelial-to-mesenchymal transition [63], and lncap invasiveness [64]
On the other hand, daidzein, which has a structure similar to that of genistein without a hydroxyl group at the c5 position, showed a weak inhibitory effect against both mao isozymes (ic 50 values of 304.05 and 356.87 µm for mao-a and -b, respectively).
The two natural isoflavone analogs gst and dz showed a dramatic difference in their mao inhibitory properties with gst being highly more potent than dz.
Genistein is a potent mao inhibitor which contributes to potentiating all other stimulants found in Oracle and is a true game changer.