I think I would start with one dose (2 caps) in the AM upon waking. Make sure you are fasted for the best effect. Another pill or full dose could be taken 6-8 hours later if desired. Yohimbe and Forskolin are great ingredients to be sure, but the EGCG/caffeine combo is also a huge metabolism boost that will devour fat. Yohimbine isn't my favorite ingredient, but the dose in this is efficacious without overloading the CNS. The thyroid boosting effects of the Forskolin are definitely a big part of this product.