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IGF-1 = Milk Engineering with rBGH

Smoky

Banned
Found this to shed a different light on IGF-1 and milk. Here is a bit of the text ...
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What is IGF-1? IGF-1 is a hormone that appears naturally in humans and cows. The IGF-1 in cows is chemically identical to the IGF-1 in humans. IGF-1 regulates cell growth, which causes cells to divide, particularly in children. This is important because cancer is defined as uncontrollable cell growth. The question then arises, will an increase of IGF-1 in genetically engineered milk cause inappropriate cell division in humans, which in turn could accelerate tumor growth?

Published research shows that rBGH injected into dairy cows substantially increases the concentration of IGF-1 in cow's milk. In an article in Science magazine in 1990, FDA scientists admitted that rBGH-tainted milk has higher levels of IGF-1. Other scientists have confirmed this conclusion. A recent report by another manufacturer of rBGH, Eli Lilly &Co., reveals a ten-fold increase in IGF-1 levels. Furthermore, there is growing evidence that IGF-1 in rBGH milk affects the human body differently than non-hormonal milk.

Contrary to industry and FDA propaganda, IGF-1 is not destroyed by pasteurization. Even according to two FDA scientists, pasteurization substantially increases IGF-1 levels in milk. Nor is IGF-1 in milk or dairy products destroyed by digestion. Moreover, the FDA acknowledges that IGF-1 is readily absorbed cross the intestinal wall: this was previously admitted by Monsanto in 1987, and further confirmation comes from leading scientists from Britain. Additionally, recent research indicates that IGF-1 can be absorbed into the bloodstream, where it can affect other hormones.
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The Bottom Line

More concerning IGF-1, milk, and your health.

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Despite assurances from the FDA and industry-paid consultants there are now just too many serious questions surrounding the use of milk from cows treated with synthetic growth hormone to allow its continued sale. Bovine growth hormone is banned in Australia, New Zealand and Japan.

The European Union has maintained its moratorium on the use of rBGH and milk products from BST-treated cows are not sold in countries within the Union. Canada has also so far resisted pressure from the United States and the biotechnology lobby to approve the use of rBGH commercially.

In light of the serious concerns about the safety of human consumption of milk from BST-treated cows consumers must maintain their vigilance to ensure that European and Canadian governments continue to resist the pressure to approve rBGH and that the FDA in the United States moves immediately to ban rBGH-milk or at least allow its labelling so that consumers can protect themselves against the very real cancer risks posed by IGF-1.

From People for the Ethical Treatment of Animals (PETA) (Invalid Link Removed)
References

1. Wilson, Jean D. and Foster, Daniel W., eds. Williams Textbook of Endocrinology, 8th edition, London, W.B. Saunders Company, 1992, pp. 1096-1106

2. Cohen, Pinchas, et al. Insulin-like growth factors (IGFs), IGF receptors, and IGF-binding proteins in primary cultures of prostate epithelial cells. Journal of Clinical Endocrinology and Metabolism, Vol. 73, No. 2, 1991, pp. 401-07

3. Rudman, Daniel, et al. Effects of human growth hormone in men over 60 years old. New England Journal of Medicine, Vol. 323, July 5, 1990, pp. 1-6

4. LeRoith, Derek, moderator. Insulin-like growth factors in health and disease. Annals of Internal Medicine, Vol. 116, May 15, 1992, pp. 854-62

5. Rosenfeld, R.G., et al. Insulin-like growth factor binding proteins in neoplasia (meeting abstract). Hormones and Growth Factors in Development and Neoplasia, Fogarty International Conference, June 26-28, 1995, Bethesda, MD, 1995, p. 24

6. Lippman, Marc E. The development of biological therapies for breast cancer. Science, Vol. 259, January 29, 1993, pp. 631-32

7. Papa, Vincenzo, et al. Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer. Cancer Research, Vol. 53, 1993, pp. 3736-40

8. Stoll, B.A. Breast cancer: further metabolic-endocrine risk markers? British Journal of Cancer, Vol. 76, No. 12, 1997, pp. 1652-54

9. LeRoith, Derek, et al. The role of the insulin-like growth factor-I receptor in cancer. Annals New York Academy of Sciences, Vol. 766, September 7, 1995, pp. 402-08

10. Mantzoros, C.S., et al. Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia. British Journal of Cancer, Vol. 76, No. 9, 1997, pp. 1115-18

11. Cascinu, S., et al. Inhibition of tumor cell kinetics and serum insulin growth factor I levels by octreotide in colorectal cancer patients. Gastroenterology, Vol. 113, September 1997, pp. 767-72

12. Chan, June M., et al. Plasma insulin-like growth factor I and prostate cancer risk: a prospective study. Science, Vol. 279, January 23, 1998, pp. 563-66

13. Epstein, Samuel S. Unlabeled milk from cows treated with biosynthetic growth hormones: a case of regulatory abdication. International Journal of Health Services, Vol. 26, No. 1, 1996, pp. 173-85

14. Epstein, Samuel S. Potential public health hazards of biosynthetic milk hormones. International Journal of Health Services, Vol. 20, No. 1, 1990, pp. 73-84

15. Epstein, Samuel S. Questions and answers on synthetic bovine growth hormones. International Journal of Health Services, Vol. 20, No. 4, 1990, pp. 573-82

16. Daughaday, William H. and Barbano, David M. Bovine somatotropin supplementation of dairy cows - Is the milk safe? Journal of the American Medical Association, Vol. 264, August 22/29, 1990, pp. 1003-05

17. Brunner, Eric. Safety of bovine somatotropin. The Lancet, September 10, 1988, p. 629 (letter to the editor)

18. Kronfeld, D.S., et al. Bovine somatotropin. Journal of the American Medical Association, Vol. 265, March 20, 1991, pp. 1389-91 (letters to the editor)

19. Rubin, Andrew L. and Goodman, Mark. Milk safety. Science, Vol. 264, May 13, 1993, pp. 889-90 (letters to the editor)

20. Challacombe, D.N., et al. Safety of milk from cows treated with bovine somatotrophin. The Lancet, Vol. 344, September 17, 1994, pp. 815-17 (letters to the editor)

21. Coghlan, Andy. Milk hormone data bottled up for years. New Scientist, October 22, 1994, p. 4

22. Coghlan, Andy. Arguing till the cows come home. New Scientist, October 29, 1994, pp. 14-15

23. Mepham, T.B., et al. Safety of milk from cows treated with bovine somatotrophin. The Lancet, Vol. 344, July 16, 1994, pp. 197-98 (letter to the editor)

24. Grossman, Charles J. Genetic engineering and the use of bovine somatotropin. Journal of the American Medical Association, Vol. 264, August 22/29, 1990, p. 1028 (editorial)

25. Juskevich, Judith C. and Guyer, C. Greg. Bovine growth hormone: human food safety evaluation. Science, Vol. 249, August 24, 1990, pp. 875-84

26. Mepham, T.B. Bovine somatotrophin and public health. British Medical Journal, Vol. 302, March 2, 1991, pp. 483-84

27. NIH technology assessment conference statement on bovine somatotropin. Journal of the American Medical Association, Vol. 265, March 20, 1991, pp. 1423-25

28. Playford, R.J., et al. Effect of luminal growth factor preservation on intestinal growth. The Lancet, Vol. 341, April 3, 1993, pp. 843-48 COMMENT: Some outstanding science documenting the reasons why you want to avoid drinking milk. Some may argue that the IGF-1 levels are not increased in organic milk and this is likely true. However, the IGF-1 is still there, as it is in all animal milks (and human as well of course). This is one of the reasons why it is a completely inappropriate food for anyone but a young child. But there are numerous other reasons to avoid drinking milk besides the IGF-1 levels (see the Young again Library under the search term "milk").

In addition to the possible cancer risk, a just-published study shows that IGF-1 may play a role in the early stages of diabetic nephropathy (Horm Res 2000;53:53-67).

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Smoky said:
Contrary to industry and FDA propaganda, IGF-1 is not destroyed by pasteurization. Even according to two FDA scientists, pasteurization substantially increases IGF-1 levels in milk. Nor is IGF-1 in milk or dairy products destroyed by digestion.
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very interesting,
milk really does do a body good :rofl:
 
This has interested me for awhile, but there are conflicting views. Some claim PETA is behind the milk bashing.
 
First, IGF-1 is a very fragile peptide. I don't think there's any way it survives the digestive tract.

Second, it is so very stupid to link "getting cancer" with IGF-1. The article doesn't mention that without IGF-1 you'd be deader than a dead dodo? Why not?

'Nuff said.
 
LOL...deader than a dead dodo...exactly what I was thinking. our bodies produce igf every night, don't they? bunch of milk bashers.
 
grunt without IGF ur cells would be in a much more apoptotic state however the IGF, NGF, EGF pathway is one of the number one cell proliferation pathways in the body and that means it is one of the many ways that causes tumors (cancer). nearly all tumors have some type of IGF mediated pathway that is mutated, amplified, deleted, or translocated in the body assisting to tumor growth. However as someone who is going to use IGF as part of my PCT i think the positives highly outway the negatives of this product and moderate use should cause no additional harm, but im not a doctor yet so dont take my word. :dance:

(+)NRG,
RZO
 
We already know that IGF-1 is naturally occurring. I perceive it a bit differently if I were a cancer patient. Causing cancer I don’t believe was the object of the articles, only its link with cellular and cancer growth. If one had a cancerous growth it would seem wise to limit the IGF-1 for treatment of an unwanted growth. Prostrate cancer qualifies here as well. Those of us in the wonder years (wondering how we ever grew so old) the risks or probabilities rise. So all I advocate is educate yourself completely and objectively. Make smart choices for only you and your body will pay its due.

Intelligent minds want to know MORE! Because the more you know... the more you know you don't know!

Lift heavy and Live Strong!
:run:
 
A big flaw in logical process here.

If IGF-1 is orally viable then why do we have to inject it?

I would bet that the incredibly small amount that is present in milk, and then "may" survive the digestion process would be so small as to have near zero effect.
 
Ahhh, take a closer look at the article, the devil is in the details...or the lack of:


"Moreover, the FDA acknowledges that IGF-1 is readily absorbed cross the intestinal wall:"

Ok, big deal. Does it make it past the stomach and liver first? What were the conditions of the study to prove this? Were they simply injecting pure igf-1 into a cadaver intestine directly and then measuring if it crossed the wall (effectively bypassing the normal digestive process?) Too many unanswered questions.


"this was previously admitted by Monsanto in 1987, and further confirmation comes from leading scientists from Britain. Additionally, recent research indicates that IGF-1 can be absorbed into the bloodstream, where it can affect other hormones."

Again, no where in this "article" do they quote research that proves at what rate that IGF-1 survives the digestive process. Why? Wouldn't it be easier to simply say "IGF-1 present in milk is readily passed onto the human body when ingested"? They could easily be talking about injected IGF-1.

But no, they dance around the actual leading conclusion.

I will reserve judgement, but I would certainly be skeptical of an article written in such a purposefully semi-scientific way.

If they were to show the measurable levels in the milk and corresponding measurable increases in blood levels in humans after ingestion then I would give much more creedence to this.
 
wither you like it or not, messing with IGF-1 can lead to cancer. IGF-1 is important cell signal for proliferation, and it has a role in regulating check point in mitosis. any increase or decrease in IGF-1 can lead to mistakes in modulating the cell signaling cascade downstream signaling pathways, which either lead to rapid apoptosis or rapid proliferation.....causing a tumor.

there is a whole chapter in my cell molecular biology book discussing this, again it wont necessarily happen, but consider the possibilities.
 
x_muscle said:
wither you like it or not, messing with IGF-1 can lead to cancer. IGF-1 is important cell signal for proliferation, and it has a role in regulating check point in mitosis. any increase or decrease in IGF-1 can lead to mistakes in modulating the cell signaling cascade downstream signaling pathways, which either lead to rapid apoptosis or rapid proliferation.....causing a tumor.

there is a whole chapter in my cell molecular biology book discussing this, again it wont necessarily happen, but consider the possibilities.
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There is what I am talking about. Probabilities ... if one has a family history or is predisposed in some way to be a likely candidate, they should thoroughly research this one and give it adequate thought. Those that have survived it for sure should stay away as I see it. But that is only an opinion as we all manage the risks every day.
 
"Contrary to industry and FDA propaganda, IGF-1 is not destroyed by pasteurization. Even according to two FDA scientists, pasteurization substantially increases IGF-1 levels in milk. Nor is IGF-1 in milk or dairy products destroyed by digestion. Moreover, the FDA acknowledges that IGF-1 is readily absorbed cross the intestinal wall: this was previously admitted by Monsanto in 1987, and further confirmation comes from leading scientists from Britain. Additionally, recent research indicates that IGF-1 can be absorbed into the bloodstream, where it can affect other hormones."

I don't buy that for a second. So I can just drink BST treated milk and forget about shelling out the bucks for IGF? If PETA says so, I tend beleive the opposite.

Yes, IGF can cause cancer cell proliferation but so can Testosterone and all the synthetic variations thereof. By that logic no one should ever do AAS, IGF, HGH, pGH et cetera but we all must weight the benefits to the risks. Hell, even creatine elevates intracellular IGF levels.

IMO one should be far more concerned with the avoidance of mutation of cells in the first place..then we can talk about avoidance of cellular proliferation. Avoiding carcinogenic reactions via healthy lifestyle choices goes a long way towards being cancer free. AAS and IGF users will probably die of heart related problems anyway.
 
Bioman I feel like you just said it better than I. Educate and make intelligent decisions. We know it isn't easy.
 
bioman said:
IMO one should be far more concerned with the avoidance of mutation of cells in the first place..then we can talk about avoidance of cellular proliferation. Avoiding carcinogenic reactions via healthy lifestyle choices goes a long way towards being cancer free. AAS and IGF users will probably die of heart related problems anyway.
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One of the best ways to accomplish this is... guess what? Getting rid of the toxic metals... :blink: I guess you'll be falling apart sometime soon... :icon_lol:
 
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